Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease
February 2025
•This report presents a rare case of co-infection with SARS-CoV-2 and HCMV in a patient with severe AIDS.•Despite suppression of SARS-CoV-2, HCMV pneumonia contributed to the patient's death.•Distinct...
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February 2025
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Antigenic analysis of the influenza B virus hemagglutinin protein
February 2025
Influenza B viruses (IBVs) primarily infect humans and are a common cause of respiratory infections in humans. Here, to systematically analyze the antigenicity of the IBVs Hemagglutinin (HA) protein,...
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Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription
Available online 27 February 2025
•SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level.•SMPD3 knockdown enhances HBV replication in various cell models, increasing...
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Phylogenitc analysis and immunogenicity comparision of porcine genotype G9 rotavirus in China from 2020-2023
Available online 21 February 2025
As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains...
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Identification and genetic analysis of new ephemeroviruses in wild boars in China
Available online 15 February 2025
Ephemeroviruses (EVs) are arthropod-borne rhabdoviruses and were isolated exclusively from cattle and haematophagous arthropods until two new ephemeroviruses were first identified from domestic pigs...
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Zika virus transmission in Aedes aegypti: a systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically
Available online 11 February 2025
Zika virus (ZIKV) is a mosquito-borne virus belonging to the genus Orthoflavivirus, and the family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, and pregnancy complications...
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Evaluating the performance of the PREDAC method in flu vaccine recommendations over the past decade (2013–2023)
Available online 28 January 2025
•PREDAC is a semi-automated and user-friendly method for flu vaccine recommendations based on HA protein sequences.•PREDAC performed comparably to the WHO in recommending vaccines of influenza A(H3N2)...
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Current antiviral therapies and promising drug candidates against respiratory syncytial virus infection
Available online 28 January 2025
Respiratory syncytial virus (RSV) is one of the most common viruses leading to lower respiratory tract infections (LRTIs) in children and elderly individuals worldwide. Although significant progress...
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Characterization of novel highly pathogenic avian influenza A(H5N6) clade 2.3.4.4b virus in wild birds, East China, 2024
Available online 21 January 2025
•We reported a novel H5N6 HPAIV belonging to clade 2.3.4.4b in wild birds in eastern China.•The novel H5N6 HPAIV most likely descended from clade 2.3.4.4b H5N1 virus in Japan.•The novel H5N6 HPAIV evolved...
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Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters
December 2024
Nipah virus (NiV) is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia. NiV leads to severe respiratory disease and encephalitis in humans and animals, with a mortality...
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A G3P[3] bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice
December 2024
•Bat rotavirus strain MSLH14 (G3P[3]) can infect human cholangiocytes in vitro.•MSLH14 can cause suckling mice biliary atresia symptom, indicating potential public health risks.•MSLH14 have the potential...
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Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai, China, 2022: A longitudinal cohort study
December 2024
The SARS-CoV-2 virus, particularly the Omicron BA.2 variant, led to a significant surge in Shanghai, 2022. However, the viral load dynamic in Omicron infections with varying clinical severities remain...
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Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV
December 2024
Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), belonging to the species Alphabaculovirus spofrugiperdae, has been recently registered as an insecticide in China. This virus has a specific...
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Single-cell RNA sequencing reveals the diversity of the immunological landscape response to genital herpes
December 2024
Genital herpes (GH) is a common sexually transmitted disease, which is primarily caused by herpes simplex virus type 2 (HSV-2), and continues to be a global health concern. Although our understanding...
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Modulation of the unfolded protein response by white spot syndrome virus via wsv406 targeting BiP to facilitate viral replication
December 2024
Outbreaks of diseases are often linked to environmental stress, which can lead to endoplasmic reticulum (ER) stress and subsequently trigger the unfolded protein response (UPR). The replication of the...
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Construction and validation of a mouse model for studying severe human adenovirus infections
December 2024
Human adenoviruses (HAdVs) are highly contagious pathogens with various genotypes implicated in acute respiratory disease (ARD) and linked to fatality, especially in immunosuppressed patients, young...
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Pandemic preparedness of effective vaccines for the outbreak of newly H5N1 highly pathogenic avian influenza virus
December 2024
•Analyzed the outbreak situation and viral characteristics of the newly H5N1 highly pathogenic avian influenza (HPAI) virus.•The current approval and research and development of the H5N1 HPAI vaccines...
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December 2024
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Bibliometric analysis of virology advancements in the 21st century
December 2024
•Databases of Web of Science, Essential Science Indicators, and Nature Index are utilized in the analysis.•More than one million publications, including 900,000 research articles are identified.•Annual...
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Ten computational challenges in human virome studies
December 2024
In recent years, substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases. Despite this progress, the field...
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Identification of mutations in viral proteins involved in cell adaptation using a reverse genetic system of the live attenuated hepatitis A virus vaccine H2 strain
December 2024
The live attenuated hepatitis A virus vaccine H2 strain was developed by passaging a wild-type H2w isolate in cell cultures. Currently, the mechanism underlying its attenuation phenotype remain largely...
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2024 Reviewer Acknowledgment
December 2024
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