Modulation of the unfolded protein response by white spot syndrome virus via wsv406 targeting BiP to facilitate viral replication
Available online 28 October 2024
Outbreaks of diseases are often linked to environmental stress, which can lead to endoplasmic reticulum (ER) stress and subsequently trigger the unfolded protein response (UPR). The replication of the...
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Case study: May human norovirus infection be associated with premature delivery?
Available online 28 October 2024
Human norovirus (HuNoV) is the leading cause of acute gastroenteritis. The varying severity of chronic infection in patients with underlying immune deficiencies poses additional burdens on public health....
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Single-cell RNA sequencing reveals the diversity of the immunological landscape response to genital herpes
Available online 18 October 2024
Genital herpes (GH) is a common sexually transmitted disease, which is primarily caused by herpes simplex virus type 2 (HSV-2), and continues to be a global health concern. Although our understanding...
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Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai, China, 2022: A longitudinal cohort study
Available online 11 October 2024
The SARS-CoV-2 virus, particularly the Omicron BA.2 variant, led to a significant surge in Shanghai, 2022. However, the viral load dynamic in Omicron infections with varying clinical severities remain...
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Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV
Available online 11 October 2024
Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), belonging to the species Alphabaculovirus spofrugiperdae, has been recently registered as an insecticide in China. This virus has a specific...
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Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening
Available online 29 September 2024
Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis has been hampered by the lack of a reverse genetics (RG) system in the past. Since 2017, multiple plasmid-based RG...
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A G3P[3] bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice
Available online 24 September 2024
•Bat rotavirus strain MSLH14 (G3P[3]) can infect human cholangiocytes in vitro.•MSLH14 can cause suckling mice biliary atresia symptom, indicating potential public health risks.•MSLH14 have the potential...
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Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters
Available online 16 September 2024
Nipah virus (NiV) is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia. NiV leads to severe respiratory disease and encephalitis in humans and animals, with a mortality...
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Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy
Available online 7 September 2024
Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), represent a substantial public health challenge as there are currently no approved treatments available....
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Antigenic analysis of the influenza B virus hemagglutinin protein
Available online 2 September 2024
Influenza B viruses (IBVs) primarily infect humans and are a common cause of respiratory infections in humans. Here, to systematically analyze the antigenicity of the IBVs Hemagglutinin (HA) protein,...
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Structural and functional insights into the 2′-O-methyltransferase of SARS-CoV-2
August 2024
A unique feature of coronaviruses is their utilization of self-encoded nonstructural protein 16 (nsp16), 2′-O-methyltransferase (2′-O-MTase), to cap their RNAs through ribose 2′-O-methylation modification....
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Measures of insulin resistance and beta cell function before and after treatment of HCV infection
August 2024
The association between chronic HCV infection and type 2 diabetes mellitus (T2DM) has been established; however, there is limited research on β-cell function particularly in the pre-diabetic population....
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Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats
August 2024
Bats are the natural reservoir hosts for SARS-related coronavirus (SARSr-CoV) and other highly pathogenic microorganisms. Therefore, it is conceivable that an individual bat may harbor multiple microbes....
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AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase
August 2024
Hand, foot and mouth disease (HFMD), mainly caused by enterovirus 71 (EV71), has frequently occurred in the Asia-Pacific region, posing a significant threat to the health of infants and young children....
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The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses
August 2024
Foxes are susceptible to SARS-CoV-2 in laboratory settings, and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in foxes. In this study, we assessed the binding capacities...
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Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy
August 2024
The landscape of hepatitis B virus (HBV) integration in the plasma cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis...
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Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection
August 2024
•Our study conducted a retrospective analysis of individuals with differing susceptibilities to COVID-19.•The correlation between cTfh cells and neutralizing antibodies enhances protection against SARS-CoV-2.•cTfh...
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Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch
August 2024
Lassa virus (LASV) is an enveloped, negative-sense RNA virus that causes Lassa hemorrhagic fever. Successful entry of LASV requires the viral glycoprotein 1 (GP1) to undergo a receptor switch from its...
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Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai, China, 2022
August 2024
•The first report of serological characteristics of HFMD associated enteroviruses in Shanghai after the COVID-19 epidemic.•The seroprevalence of protective NtAbs against Coxsackieviruses was low within...
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A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice
August 2024
Norovirus (NoV) infection is a major cause of gastroenteritis worldwide. The virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic diversity....
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Transmission restriction and genomic evolution co-shape the genetic diversity patterns of influenza A virus
August 2024
Influenza A virus (IAV) shows an extensive host range and rapid genomic variations, leading to continuous emergence of novel viruses with significant antigenic variations and the potential for cross-species...
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RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qīnghăi Province, China
August 2024
Ticks are a major parasite on the Qīnghăi-Tibet Plateau, western China, and represent an economic burden to agriculture and animal husbandry. Despite research on tick-borne pathogens that threaten humans...
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August 2024
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