Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023
Available online 18 May 2024
•H1N1 strains were collected from Hunan and Jiangsu provinces in early 2023 following the optimized COVID-19 strategy.•Phylogenic analysis revealed that the epidemic H1N1 viruses fell into different...
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First complete genomic sequence analysis of canine distemper virus in wild boar
Available online 18 May 2024
•The first complete genomic sequence of canine distemper virus from wild boar in northeast China was obtained.•Phylogenetic analysis showed that this wild boar CDV strain belongs to the Arctic lineage.•Wild...
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NSUN2 mediates distinct pathways to regulate enterovirus 71 replication
Available online 18 May 2024
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function...
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DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice
Available online 18 May 2024
As of December 2022, 2,603 cases laboratory-identified Middle East respiratory syndrome coronavirus (MERS-CoV) infections and 935 associated deaths, with a mortality rate of 36%, had been reported to...
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Design of antiviral AGO2-dependent short hairpin RNAs
Available online 9 May 2024
The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that...
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Ten computational challenges in human virome studies
Available online 30 April 2024
In recent years, substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases. Despite this progress, the field...
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Joint deletion of multifunctional MGF505-7R and H240R genes generates a safe and effective African swine fever virus attenuated live vaccine candidate
Available online 30 April 2024
•MGF505-7R and H240R are virulence-related genes.•ASFV-ΔMGF505-7R-ΔH240R is attenuated.•The candidate vaccine is safe and protective....
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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection
April 2024
Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues...
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Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China
April 2024
•We reported the first MPXV strain hMpxV/China/SZ-SZTH42/2023 isolated in southern China.•The isolate SZTH42 belongs to C.1 lineage of clade IIb, representing the currently prevalent IIb branch strain...
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C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus
April 2024
Influenza A virus (IAV) binds sialic acid receptors on the cell surface to enter the host cells, which is the key step in initiating infection, transmission and pathogenesis. Understanding the factors...
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PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity
April 2024
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major economically devastating pathogen that has evolved various strategies to evade innate immunity. Downregulation of antiviral interferon...
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Cross-species transmission and host range genes in poxviruses
April 2024
The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread of MPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and...
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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong
April 2024
•Full-length genome sequences of reassortant swine influenza A(H1N2) virus from domestic pigs in Hong Kong SAR.•These swine influenza A(H1N2) viruses are closely related with those circulating in Taiwan.•Swine...
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Non-proteolytic ubiquitination of HBx controls HBV replication
April 2024
•The expression level of TRIM21 in patients is negatively correlated with the replication and integration of HBV.•TRIM21 was found to trigger non-proteolytic ubiquitination of X protein of HBV.•This...
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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G
April 2024
The SARS-CoV-2 Omicron variants are notorious for their transmissibility, but little is known about their subgenomic RNA (sgRNA) expression. This study applied RNA-seq to delineate the quantitative...
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Coxsackievirus B3 HFMD animal models in Syrian hamster and rhesus monkey
April 2024
Coxsackievirus B3 (CVB3) is the pathogen causing hand, foot and mouth disease (HFMD), which manifests across a spectrum of clinical severity from mild to severe. However, CVB3-infected mouse models...
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The evolution, pathogenicity and transmissibility of quadruple reassortant H1N2 swine influenza virus in China: A potential threat to public health
April 2024
Swine are regarded as “intermediate hosts” or “mixing vessels” of influenza viruses, capable of generating strains with pandemic potential. From 2020 to 2021, we conducted surveillance on swine H1N2...
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Viromes of Haemaphysalis longicornis reveal different viral abundance and diversity in free and engorged ticks
April 2024
Haemaphysalis longicornis ticks, commonly found in East Asia, can transmit various pathogenic viruses, including the severe fever with thrombocytopenia syndrome virus (SFTSV) that has caused febrile...
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Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population
April 2024
•Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide are validated in Chinese population.•Variants in DPP9 and near RNU2-47P and TYRP1 show the strongest associated...
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Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening
April 2024
Hand, foot, and mouth disease (HFMD) is a common pediatric illness mainly caused by enteroviruses, which are important human pathogens. Currently, there are no available antiviral agents for the therapy...
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Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury
April 2024
SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of COVID-19. Our research, along with others', has demonstrated that mast cells (MCs) play a vital role in the initiation of...
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The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes
April 2024
Guaico Culex virus (GCXV) is a newly identified segmented Jingmenvirus from Culex spp. mosquitoes in Central and South America. The genome of GCXV is composed of four or five single-stranded positive...
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Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients
April 2024
Naturally occurred precore (PC, G1896A) and/or basal core promoter (BCP, A1762T/G1764A) mutations are prevalent in chronic HBV-infected patients, especially those under HBeAg-negative status. However,...
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April 2024
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Structural analysis of conformational changes in the mpox virus A7 protein
April 2024
•Phospholipid-binding abilities of mpox virus A7 protein and its truncations are investigated.•The structures of the N-terminal truncations of A7 protein (A7N121 and A7N137) are determined.•Conformational...
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