The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission
Available online 28 March 2025
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in mutations not only in the spike protein, aiding immune evasion, but also in the NSP3/4/6 proteins, crucial...
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Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus
Available online 27 March 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging acute infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), characterized by high fever and thrombocytopenia....
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Insights into cross-species infection by coronavirus: Porcine epidemic diarrhea virus infections in the rodent
Available online 27 March 2025
The cross-species infection of coronaviruses has resulted in several major epidemics since 2003. Therefore, it is of great importance to explore the host ranges of coronaviruses and their features among...
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Development of a reporter HBoV1 strain for antiviral drug screening and life cycle studies
Available online 25 March 2025
Human bocavirus 1 (HBoV1; family: Parvoviridae) causes a wide spectrum of respiratory diseases in children and gastroenteritis in adults. A lack of sensitive cell lines and efficient animal models hinders...
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Development and immunoprotection assessment of novel vaccines for avian infectious bronchitis virus
Available online 25 March 2025
Infectious bronchitis (IB), a highly contagious acute respiratory disease affecting avian species, poses significant challenges to poultry production. The causative agent, Infectious Bronchitis Virus...
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Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4+ T cell
Available online 24 March 2025
Naf1 (Nef-associated factor 1) is a host protein that interacts with human immunodeficiency virus type 1 (HIV-1) Nef protein. We and others have previously demonstrated that Naf1 restricts HIV-1 infection...
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Virus profiling of bronchoalveolar lavage fluid in hospitalized non-COVID-19 adult patients with pulmonary infection from November 2020 to November 2021
Available online 20 March 2025
Identifying the cause of respiratory tract infections is important for reducing the burden of diagnosis and treatment. To assess viral etiologies of hospitalized patients with pulmonary infection (including...
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The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D
Available online 19 March 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of novel coronavirus disease 2019, can cause acute respiratory symptoms and even death globally. However, the immune...
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Epidemiological and molecular characteristics of human parainfluenza virus in southern China during 2016–2020
Available online 18 March 2025
Human parainfluenza viruses (HPIV) are common viral pathogens in acute respiratory infection (ARI). We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients....
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Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein
Available online 15 March 2025
•A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time.•The B cell epitope of PAstV5 capsid protein was identified for the first time.•The monoclonal...
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In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs
Available online 15 March 2025
Porcine reproductive and respiratory syndrome (PRRS), a highly infectious immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), has led to significant economic...
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Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis
Available online 3 March 2025
Artemisia annua L. is a medicinal herb with multiple therapeutic applications, whereas its anti-influenza A virus (IAV) efficiency and mechanism of action are still unclear. Here, we investigated the...
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Rapid preparation and characterization of pan-sarbecovirus mRNA vaccine candidates based on the receptor binding domain
February 2025
•We developed a rapid approach for small-scale mRNA vaccine preparation against pan-sarbecovirus infection.•An mRNA vaccine developed on this platform effectively elicits the production of neutralizing...
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Discovery and characterization of a novel carlavirus in Ligularia jaluensis plants
February 2025
Ligularia jaluensis is an important medicinal and ornamental plant in China. However, the viruses capable of infecting Ligularia jaluensis remains unknown. Here, we identified a novel carlavirus, tentatively...
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Insights into recent advancements in human and animal rotavirus vaccines: Exploring new frontiers
February 2025
Rotavirus infections cause severe gastroenteritis and dehydration in young children and animals worldwide, leading to high rates of morbidity and mortality, predominantly in low- and middle-income countries....
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Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China
February 2025
On January 30, 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution...
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PB2 627V and HA 217 sites synergistically affect the lethality of H9N2 in mice
February 2025
The H9N2 subtype avian influenza virus (AIV) continues to propagate and undergo evolution within China, thereby posing a significant threat to the poultry industry. This study encompassed the collection...
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Comparative analysis between genotypes of adenovirus isolates from hospitalized children with acute respiratory tract infections and clinical manifestations in Wuhan, China, from June 2022 to September 2023
February 2025
Acute respiratory tract infections (ARTIs) are among the leading causes of morbidity and mortality in children worldwide. Human adenovirus (HAdV) infections are estimated to account for at least 5%...
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The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
February 2025
Traditional Chinese medicine has unique advantages in preventing and treating COVID-19, and Fuzheng Jiedu decoction (FZJDD) was reported to be effective against COVID-19 in clinical trials. To investigate...
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CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB
February 2025
Virus-encoding RNA-dependent RNA polymerase (RdRp) is essential for genome replication and gene transcription of human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus...
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A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity
February 2025
Influenza, a highly contagious respiratory infectious disease caused by an influenza virus, is a threat to public health worldwide. Avian influenza viruses (AIVs) have the potential to cause the next...
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Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus
February 2025
A switch from avian-type α-2,3 to human-type α-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus. Some H9N2 viruses exhibit a preference for binding...
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Patterns of liver fibrosis evolution in Chinese HIV/HBV co-infected adults following 5-year antiretroviral treatment: A longitudinal study using non-invasive APRI and Fib-4 scores
February 2025
The long-term effects of combined antiretroviral therapy (ART) on liver fibrosis patterns in adults living with human immunodeficiency virus (HIV) and chronic hepatitis B virus (HBV) are not well understood....
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Zika virus infections and associated risk factors among pregnant women in Gombe, Nigeria
February 2025
In-utero exposure to Zika virus (ZIKV) could lead to miscarriage, preterm birth and congenital Zika syndrome. This study aimed at estimating the burden of ZIKV and Dengue virus (DENV) infections among...
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Geographical distribution and characterization of Jingmen tick virus in wild boars in China
February 2025
•JMTV RNA was identified in 9 out of 26 provinces with an average wild boar infection rate of 5.45% (25/459).•Phylogenetic analysis indicated that JMTV strains could be divided into two groups, but...
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