Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease
Available online 10 January 2025
•This report presents a rare case of co-infection with SARS-CoV-2 and HCMV in a patient with severe AIDS.•Despite suppression of SARS-CoV-2, HCMV pneumonia contributed to the patient's death.•Distinct...
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Geographical distribution and characterization of Jingmen tick virus in wild boar in China
Available online 1 January 2025
•JMTV RNA was identified in 9 out of 26 provinces with an average wild boar infection rate of 5.45% (25/459).•Phylogenetic analysis indicated that JMTV strains could be divided into two groups, but...
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Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy
December 2024
Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), represent a substantial public health challenge as there are currently no approved treatments available....
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Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters
December 2024
Nipah virus (NiV) is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia. NiV leads to severe respiratory disease and encephalitis in humans and animals, with a mortality...
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Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening
December 2024
Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis has been hampered by the lack of a reverse genetics (RG) system in the past. Since 2017, multiple plasmid-based RG...
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A G3P[3] bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice
December 2024
•Bat rotavirus strain MSLH14 (G3P[3]) can infect human cholangiocytes in vitro.•MSLH14 can cause suckling mice biliary atresia symptom, indicating potential public health risks.•MSLH14 have the potential...
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Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai, China, 2022: A longitudinal cohort study
December 2024
The SARS-CoV-2 virus, particularly the Omicron BA.2 variant, led to a significant surge in Shanghai, 2022. However, the viral load dynamic in Omicron infections with varying clinical severities remain...
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Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV
December 2024
Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), belonging to the species Alphabaculovirus spofrugiperdae, has been recently registered as an insecticide in China. This virus has a specific...
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Single-cell RNA sequencing reveals the diversity of the immunological landscape response to genital herpes
December 2024
Genital herpes (GH) is a common sexually transmitted disease, which is primarily caused by herpes simplex virus type 2 (HSV-2), and continues to be a global health concern. Although our understanding...
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Modulation of the unfolded protein response by white spot syndrome virus via wsv406 targeting BiP to facilitate viral replication
December 2024
Outbreaks of diseases are often linked to environmental stress, which can lead to endoplasmic reticulum (ER) stress and subsequently trigger the unfolded protein response (UPR). The replication of the...
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Case study: May human norovirus infection be associated with premature delivery?
December 2024
Human norovirus (HuNoV) is the leading cause of acute gastroenteritis. The varying severity of chronic infection in patients with underlying immune deficiencies poses additional burdens on public health....
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The first discovery of severe fever with thrombocytopenia virus in the center of metropolitan Beijing, China
December 2024
Severe fever with thrombocytopenia virus (SFTSV), an emerging tick-borne bandavirus, poses a significant public health threat in rural China. Since 2021, an increase of local cases has been noted in...
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Construction and validation of a mouse model for studying severe human adenovirus infections
December 2024
Human adenoviruses (HAdVs) are highly contagious pathogens with various genotypes implicated in acute respiratory disease (ARD) and linked to fatality, especially in immunosuppressed patients, young...
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Pandemic preparedness of effective vaccines for the outbreak of newly H5N1 highly pathogenic avian influenza virus
December 2024
•Analyzed the outbreak situation and viral characteristics of the newly H5N1 highly pathogenic avian influenza (HPAI) virus.•The current approval and research and development of the H5N1 HPAI vaccines...
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Issue Cover
December 2024
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Bibliometric analysis of virology advancements in the 21st century
December 2024
•Databases of Web of Science, Essential Science Indicators, and Nature Index are utilized in the analysis.•More than one million publications, including 900,000 research articles are identified.•Annual...
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Ten computational challenges in human virome studies
December 2024
In recent years, substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases. Despite this progress, the field...
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Identification of mutations in viral proteins involved in cell adaptation using a reverse genetic system of the live attenuated hepatitis A virus vaccine H2 strain
December 2024
The live attenuated hepatitis A virus vaccine H2 strain was developed by passaging a wild-type H2w isolate in cell cultures. Currently, the mechanism underlying its attenuation phenotype remain largely...
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2024 Reviewer Acknowledgment
December 2024
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Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus
Available online 31 December 2024
A switch from avian-type α-2,3 to human-type α-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus. Some H9N2 viruses exhibit a preference for binding...
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Patterns of liver fibrosis evolution in Chinese HIV/HBV co-infected adults following 5-year antiretroviral treatment: a longitudinal study using non-invasive APRI and Fib-4 scores
Available online 31 December 2024
The long-term effects of combined antiretroviral therapy (ART) on liver fibrosis patterns in adults living with HIV and chronic hepatitis B virus (HBV) are not well understood. Therefore, this study...
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Zika virus infections and associated risk factors among pregnant women in Gombe, Nigeria
Available online 30 December 2024
In-utero exposure to Zika virus (ZIKV) could lead to miscarriage, preterm birth and children with congenital Zika syndrome. This study aimed at estimating the burden of ZIKV infection among pregnant...
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The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
Available online 28 December 2024
Traditional Chinese medicine has unique advantages in preventing and treating COVID-19, and Fuzheng Jiedu decoction (FZJDD) was reported to be effective against COVID-19 in clinical trials. To investigate...
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CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB
Available online 28 December 2024
Virus-encoding RNA-dependent RNA polymerase (RdRp) is essential for genome replication and gene transcription of human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus...
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A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity
Available online 28 December 2024
Influenza, a highly contagious respiratory infectious disease caused by an influenza virus, is a threat to public health worldwide. Avian influenza viruses (AIVs) have the potential to cause the next...
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