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Health research in the era of artificial intelligence: Advances in gene-editing study
June 2024
In recent years, gene editing technology, represented by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) has made a revolutionary breakthrough....
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Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant
June 2024
With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked...
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Osteoblast-derived extracellular vesicles exert bone formation effects by WIF1-mediated regulation of mitophagy
June 2024
Osteoporosis arises mainly from an imbalance in bone remodeling, characterized by the impaired ability of osteoblasts (OBs) to form new bone. A significant challenge remains in identifying and validating...
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Delayed treatment effect predicting (DTEP) model for guiding immuno-oncology trial designs
March 2024
The presence of delayed treatment effects (DTE) is common in immuno-oncology trials. However, conventional trial designs often overlook the potential presence of DTE, which can result in an underestimation...
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Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
March 2024
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate...
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Artificial intelligence in coronary computed tomography angiography
March 2024
The rapid development of artificial intelligence (AI) technologies, like machine learning, deep learning, and other algorithms applied to the intelligent diagnostic and decision making, image interpretation,...
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Nitrate and body homeostasis
March 2024
Homeostasis is essential for the maintenance of health, and how it is maintained is the focus of attention in homeostatic medicine. As a natural dietary nutrient, nitrate is critical in regulating homeostasis....
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Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery
March 2024
Degrader technologies provide unprecedented strategies to tackle diseases caused by pathogenic proteins that are difficult to target by the traditional inhibitor approach. One pioneering technology,...
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Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder
March 2024
Early-onset schizophrenia (EOS) and autism spectrum disorder (ASD) are two mental disorders with abnormal neurodevelopment and overlapping clinical symptoms. However, few prospective multi-center imaging...
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