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Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
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Structural and biochemical basis for the pathogenic mutations of methylmalonate semialdehyde dehydrogenase ALDH6A1
December 2024
Methylmalonate semialdehyde dehydrogenase (ALDH6A1), encoded by the ALDH6A1 gene, is essential for the metabolic degradation of valine and thymine. Genetic alterations in ALDH6A1 lead to methylmalonate...
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Associations of long-term exposure to fine particulate matter and its constituents with gynecologic cancer incidence: A prospective cohort study from Beijing
December 2024
There is limited evidence of the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 µm (fine particulate matter, PM2.5) and gynecologic cancer incidence, particularly...
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Trend in sepsis burden among hospitalized non-child cancer patients in China, 2017–2019: a nationwide cross-sectional study
Available online 20 November 2024
The trend in sepsis burden among cancer patients, along with geographic variation and the impact of healthcare resource availability, remains underexplored in China. This study was conducted to evaluate...
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Diagnosis and treatment of neurally mediated syncope in children and adolescents: A hot issue in pediatrics
Available online 19 November 2024
Syncope, a transient loss of consciousness due to cerebral hypoperfusion, is common in the young. The etiological spectrum, pathogenesis, diagnosis and treatment of syncope in children and adolescents...
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Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases
Available online 17 November 2024
Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and other tauopathies. Intracellular...
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Biomimetic cell-adaptive and rigid natural extracellular matrix hydrogels: Repair strategies from cartilage to subchondral bone
September 2024
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Big connectome imaging data in psychiatric disorders
September 2024
Psychiatric disorders are a pressing public health challenge, posing a significant threat to the well-being of millions of people worldwide. Their elusive etiology, rooted in the complex interplay of...
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Boron neutron capture therapy of cancer: Recent progress
September 2024
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Translating “AI for omics” into precision therapy
September 2024
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Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study
September 2024
Cachexia is a global burden that is caused by chronic diseases such as cancer. It is characterized by inflammation and progressive loss of muscle and adipose tissue, aggravating the patient’s health....
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Relationship between tight junctions of the BBB and astrocyte connective function in epilepsy: Albumin and astrocyte activation
September 2024
The blood-brain barrier (BBB) is a barrier system separating the central nervous system from blood circulation. Connections between cells within the BBB involve specialized endothelial tight junction...
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Intracranial neurophysiological correlates of rumination: A cross-sectional observational study
September 2024
Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders, albeit its neurophysiological basis remains elusive. Existing neuroimaging studies...
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Tumor deposits in colorectal and gastric cancers
June 2024
Tumor deposits (TDs), initially recognized in colorectal cancer (CRC), have been identified in various other cancer types, including gastric cancer (GC), rendering them a widely studied adverse prognostic...
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A molecular glue for P53
June 2024
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Progresses in genetic testing in congenital heart disease
June 2024
Congenital heart disease (CHD) encompasses a range of structural malformations affecting the heart and major blood vessels present at birth. The genetic underpinnings of CHD have long been recognized...
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Targeting RIP3 inhibits osteoarthritis development by restoring anabolic-catabolic balance in the bone-cartilage unit
June 2024
Osteoarthritis (OA) is a debilitating joint disorder characterized by progressive cartilage degeneration. During OA, subchondral bone undergoes microstructural and molecular changes that precede cartilage...
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