Targeting neural components in the tumor microenvironment as a novel therapeutic approach
March 2025
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Progress in clinical research on allogeneic hematopoietic stem cell transplantation for the treatment of paroxysmal nocturnal hemoglobinuria
March 2025
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal proliferative disease of hematopoietic stem cells that is clinically characterized by hemolysis, thrombosis, and bone marrow failure. In recent...
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Progress and challenges in infectious disease surveillance and early warning
March 2025
The increasing incidence of emerging infectious diseases emphasizes the urgent need for timely and accurate global surveillance and early warning systems. In recent years, infectious disease surveillance...
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Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
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Structural and biochemical basis for the pathogenic mutations of methylmalonate semialdehyde dehydrogenase ALDH6A1
December 2024
Methylmalonate semialdehyde dehydrogenase (ALDH6A1), encoded by the ALDH6A1 gene, is essential for the metabolic degradation of valine and thymine. Genetic alterations in ALDH6A1 lead to methylmalonate...
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Associations of long-term exposure to fine particulate matter and its constituents with gynecologic cancer incidence: A prospective cohort study from Beijing
December 2024
There is limited evidence of the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 µm (fine particulate matter, PM2.5) and gynecologic cancer incidence, particularly...
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Trend in sepsis burden among hospitalized non-child cancer patients in China, 2017–2019: A nationwide cross-sectional study
December 2024
The trend in sepsis burden among cancer patients, along with geographic variation and the impact of healthcare resource availability, remains underexplored in China. This study was conducted to evaluate...
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Diagnosis and treatment of neurally mediated syncope in children and adolescents: A hot issue in pediatrics
December 2024
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Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases
December 2024
Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and other tauopathies. Intracellular...
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Biomimetic cell-adaptive and rigid natural extracellular matrix hydrogels: Repair strategies from cartilage to subchondral bone
September 2024
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Big connectome imaging data in psychiatric disorders
September 2024
Psychiatric disorders are a pressing public health challenge, posing a significant threat to the well-being of millions of people worldwide. Their elusive etiology, rooted in the complex interplay of...
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Boron neutron capture therapy of cancer: Recent progress
September 2024
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Translating “AI for omics” into precision therapy
September 2024
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Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study
September 2024
Cachexia is a global burden that is caused by chronic diseases such as cancer. It is characterized by inflammation and progressive loss of muscle and adipose tissue, aggravating the patient’s health....
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Relationship between tight junctions of the BBB and astrocyte connective function in epilepsy: Albumin and astrocyte activation
September 2024
The blood-brain barrier (BBB) is a barrier system separating the central nervous system from blood circulation. Connections between cells within the BBB involve specialized endothelial tight junction...
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