Targeting neural components in the tumor microenvironment as a novel therapeutic approach
March 2025
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Progress in clinical research on allogeneic hematopoietic stem cell transplantation for the treatment of paroxysmal nocturnal hemoglobinuria
March 2025
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal proliferative disease of hematopoietic stem cells that is clinically characterized by hemolysis, thrombosis, and bone marrow failure. In recent...
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Progress and challenges in infectious disease surveillance and early warning
March 2025
The increasing incidence of emerging infectious diseases emphasizes the urgent need for timely and accurate global surveillance and early warning systems. In recent years, infectious disease surveillance...
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A cross-sectional analysis of dietary intake and abdominal visceral fat content measured by ultrasound sonography
March 2025
The assessment of abdominal visceral fat (VF) warrants more applicable screening methods to detect individuals at risk of developing comorbidities. The purpose of this study was to identify a practical...
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Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies
March 2025
Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors. Several international authoritative societies have developed a number of guidelines to standardize...
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Global patterns of cervical cancer incidence and mortality: updated statistics and an overview of temporal trends from 2003 to 2017
Available online 24 March 2025
Global disparities exist in the burden of cervical cancer. This study aims to describe and analyze the global epidemiological landscape of cervical cancer in 2022, including recent trends in incide...
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Computational biomedical imaging: AI innovations and pitfalls
Available online 21 March 2025
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Perspective to clinical translation of radiotherapy-activated prodrugs: challenges and advances
Available online 7 March 2025
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Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
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Structural and biochemical basis for the pathogenic mutations of methylmalonate semialdehyde dehydrogenase ALDH6A1
December 2024
Methylmalonate semialdehyde dehydrogenase (ALDH6A1), encoded by the ALDH6A1 gene, is essential for the metabolic degradation of valine and thymine. Genetic alterations in ALDH6A1 lead to methylmalonate...
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Associations of long-term exposure to fine particulate matter and its constituents with gynecologic cancer incidence: A prospective cohort study from Beijing
December 2024
There is limited evidence of the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 µm (fine particulate matter, PM2.5) and gynecologic cancer incidence, particularly...
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Trend in sepsis burden among hospitalized non-child cancer patients in China, 2017–2019: A nationwide cross-sectional study
December 2024
The trend in sepsis burden among cancer patients, along with geographic variation and the impact of healthcare resource availability, remains underexplored in China. This study was conducted to evaluate...
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Diagnosis and treatment of neurally mediated syncope in children and adolescents: A hot issue in pediatrics
December 2024
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Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases
December 2024
Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and other tauopathies. Intracellular...
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Biomimetic cell-adaptive and rigid natural extracellular matrix hydrogels: Repair strategies from cartilage to subchondral bone
September 2024
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Big connectome imaging data in psychiatric disorders
September 2024
Psychiatric disorders are a pressing public health challenge, posing a significant threat to the well-being of millions of people worldwide. Their elusive etiology, rooted in the complex interplay of...
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Boron neutron capture therapy of cancer: Recent progress
September 2024
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