Iridium-Catalyzed asymmetric reduction of α,β-Unsaturated nitriles with water
August 2024
The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals, and the nitrile groups are versatile synthetic intermediates to other functionalized compounds....
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Metal-free and water-compatible nanocatalysts for green photocatalytic dehydrogenation in aqueous medium
August 2024
Two types of poly-porphyrin-based heterogeneous photocatalysts including insoluble polymer and water-soluble nanoparticles exhibited excellent photocatalytic activity in visible-light-induced dehydrogenation...
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N-Doped graphene fiber anchored Pd nanoparticles as a fixed-bed catalyst for continuous-flow reduction of N-containing unsaturated compounds
August 2024
Catalytic fixed-bed is an efficient and facile system for scalable organic synthesis due to its continuous and fast flow operation process. As a key unit in the fixed-bed system, catalytically active...
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Pd(II)/N,N′-Disulfonyl bisimidazoline-catalyzed asymmetric arylation of isoquinoline-1,3,4-trione-derived ketimines
August 2024
A palladium/chiral N,N′-disulfonyl bisimidazoline (Bim)-catalyzed asymmetric addition of arylboronic acids to isoquinoline-1,3,4-trione-derived ketimines is reported, leading to the generation of a...
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Copper-catalyzed 2,3-dihydro-1,2,4-triazoles synthesis through [3+2]-cycloaddition of nitrile ylides with azodicarboxylates
August 2024
A copper-catalyzed three-component reaction of diazo compounds, nitriles, and azodicarboxylates to construct 2,3-dihydro-1,2,4-triazoles is reported. Key to the success is the utilization of azodicarboxylates...
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A H2O2 generation-detection-regulation integrated platform for boosting the efficiency of peroxygenase-catalysed C–H oxidative hydroxylation
August 2024
The peroxygenases are ideal biocatalysts for the selective oxyfunctionalisation of stable C–H bonds. However, the catalytic efficiency of this approach is limited due to enzyme lability toward oxidant...
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Metal- and light-free approach to polyheterocycles via a quinone-Cs2CO3 couple promoted regioselective cascade radical cyclization
August 2024
A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope...
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Synthesis of highly functional quinazolins via metal-free, visible-light-enabled radical cascade arylation/cyclization of fluorinated imidoyl isothiocyanates
August 2024
A metal-free, efficient and easy-to-hand protocol for the synthesis of 2-perfluoroalkylquinazolins has been achieved by Eosin B catalyzed radical cascade arylation/cyclization reaction of fluorinated...
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Rhodium/Ming-Phos-catalyzed asymmetric annulation reaction of silacyclobutanes with terminal alkynes
August 2024
Asymmetric ring-expansion reactions of silacyclobutanes (SCBs) with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds. However, the achievement...
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Photoredox/Ti dual-catalyzed dehydroxylative ring-opening Giese reaction of cyclobutanone oximes
August 2024
A dehydroxylative ring-opening Giese reaction of cyclobutanone oximes enabled by photoredox/Ti dual catalysis has been reported in this work. This protocol avoids the prefunctionalization of oximes...
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A sustainable synthesis of 3,3-disubstituted oxindoles via CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile
August 2024
We herein reported a sustainable synthesis of 3,3-disubstituted oxindoles via a Michael-type reaction based on the CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile....
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Chiral bis(imidazoline) NCN pincer iridium(III)-catalyzed enantioselective alkynylation of trifluoropyruvates with terminal alkynes
Available online 29 August 2024
Readily prepared chiral bis(imidazoline) NCN pincer iridium(III) complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes...
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Highly efficient palladacycle-catalyzed carboxylation of benzyl alcohols
Available online 28 August 2024
A general and practical carboxylation of benzyl alcohols using the air- and moisture-stable Herrmann-Beller palladacycle was developed. With this novel methodology, numerous carboxylated products were...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Iron-catalyzed non-directed arene C-H difluoromethylation
Available online 27 August 2024
Practical, undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis. We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled...
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Electrochemical difunctionalization of isocyanides by a three-component reaction cascade Mumm rearrangement: rapid access to sulfur-containing imides
Available online 26 August 2024
An efficient and practical electrochemical method for the three-component reaction cascade Mumm rearrangement of imides has been developed using a simple undivided cell with carbon electrodes at room...
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Green polyurethanes from bio-based building blocks: recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers thanks to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable...
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A spirosilane ligand induced highly enantioselective Rh-catalyzed cycloisomerization of 1,6-enynes
Available online 21 August 2024
Transition metal-catalyzed cycloisomerization of 1,6-enynes is a highly effective approach to generating five-membered rings. Among the various catalytic systems developed, the use of chiral ligands...
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Photocatalytic selective 1,4-oxyimination/diamination across C=C and N=N bonds to access structurally diverse N-N-N triazane derivatives
Available online 2 August 2024
A highly selective and atom-economical multi-component remote difunctionalization strategy has been successfully developed. This strategy utilizes precise control over the radical properties of bifunctional...
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Synthesis of 1,4-oxathiins via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides
Available online 26 July 2024
A straightforward and valuable approach for the synthesis of 1,4-oxathiins has been developed via [3 + 3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides. C–S and C–O bonds...
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Light-driven enzymatic conversion of mevastatin into pravastatin by coupling P450sca-2 with cyanobacterial photosynthetic system
Available online 16 July 2024
Cytochrome P450 enzymes (P450s) are highly attractive green biocatalysts with application potential in fields of synthetic chemistry and synthetic biology. However, most P450 enzymatic reactions rely...
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Electrochemical selective deuterium labelling of N-heteroarenes
Available online 24 June 2024
Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective...
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Transformation of ambient CO2 in air into cyclic carbonates mediated by a phosphorus-nitrogen PN3-pincer iron complex
Available online 17 June 2024
The atom-economical reaction of carbon dioxide (CO2) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for...
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Stereoselective oxidative C3–N bond dehydrogenation and aromatization of 1-carboxyl substituted tetrahydroisoquinolines employing pipecolate oxidase
Available online 10 June 2024
The dehydrogenation of C–N bond in 1,2,3,4-tetrahydroisoquinolines (THIQs), especially 1-substituted THIQs, is a type of fascinating transformation owing to its utility in synthetic organic chemistry....
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Photocatalyzed chemodivergent aerobic oxidation of naturally occurring Viridicatin and derivatives
Available online 5 June 2024
A chemodivergent reaction is an appealing way to construct molecules with enriched structure diversity in a controlled manner. A plethora of methodologies were developed based on this concept, and transition...
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