Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters
Available online 19 November 2024
In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic...
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Palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes: a strain release approach toward alkylidenecyclobutanes
Available online 16 November 2024
A palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes with amines is described. This protocol is featured with its novel activation model, broad substrate scope and mild reaction conditions,...
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A direct Ni-catalyzed deoxygenative Suzuki-Miyaura cross-coupling reaction of phenols via the formation of active O-phenyluronium
Available online 14 November 2024
Herein, we demonstrate that activation of phenols by tetramethylfluoroformamidinium hexafluorophosphate (TFFH) enables the establishment of the general Ni-catalyzed method for deoxygenative Suzuki-Miyaura...
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Advanced green synthesis: Solvent-free and catalyst-free reaction
Available online 9 November 2024
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Enhancing the catalytic efficiency of nitrilase for sterically hindered substrates by distal sites engineering
Available online 8 November 2024
Nitrilases are enzymes capable of converting nitriles into carboxylic acids under mild conditions. However, wild type nitrilases typically exhibit poor catalytic efficiency towards sterically hindered...
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Green solvent-controlled switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles
Available online 8 November 2024
The BF3·OEt2 promoted switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles from readily available feedstocks was developed by the adjustment of green solvents EA and...
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Electrochemical late-stage modification of hydralazine an antihypertensive drug. A green strategy for the synthesis of nano-structured new sulfonylhydrazine derivatives
Available online 28 October 2024
This work is focused on the electrochemical late-stage modification of hydralazine (1-hydrazinylphthalazine) (HYD), a common antihypertensive drug, and the synthesis of its new sulfonylhydrazine derivatives....
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Chemo- and diastereoselective four-component reactions with Rh carbynoids
Available online 28 October 2024
Multi-component reactions (MCRs) provide an efficient method for constructing multiple chemical bonds by combining three or more starting materials in a single operational step, enabling rapid and cost-effective...
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Organocatalytic asymmetric cyclization of aminochalcones and azlactones: synthesis of 3,4-dihydroquinolinones
Available online 28 October 2024
A novel and efficient reaction of aminochalcones and azlactones has been developed under the catalysis of bifunctional organocatalysts. The corresponding enantioenriched 3,4-dihydroquinolinones were...
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Electrochemical C-H thiocyanation of BODIPYs: two birds with one stone of KSCN
Available online 24 October 2024
An efficient electrochemical C-H thiocyanation of BODIPYs was developed by using potassium thiocyanide as the source of thiocyanation. The straightforward C-H thiocyanation protocol possesses many advantages:...
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Photoredox decarboxylative acylation of carboxylic acid by 4-acyl-1,2,3-triazoliums
Available online 18 October 2024
Recent advancements in NHC-based radical coupling reactions have introduced NHC-derived ketyl radicals as innovative persistent radicals. However, current work involves NHC-based radical-radical coupling...
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Brønsted acid catalyzed green and efficient construction of α-amino peroxides from 3-hydroxyisoindolinones and hydroperoxides
Available online 16 October 2024
A Brønsted acid-catalyzed peroxidation of 3-hydroxyisoindolinones with hydroperoxides has been established for the first time, which constructs α-amino peroxides bearing a tetrasubstituted stereocenter...
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Divergent asymmetric reactions of α-alkenyl ketones with β,γ-alkynyl-α-imino esters enabled by chiral phosphoric acids
Available online 15 October 2024
Divergent asymmetric synthesis provides access to a wide range of isomers from the same starting material by modifying the reaction conditions, which plays an important role in the efficient construction...
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Transition-metal-free defluorinative cyclization of perfluoroalkyl alkenyl iodides with C,N-dinucleophiles: Synthesis of (E)-perfluoroalkenyl pyrroles
Available online 11 October 2024
Functionalization of the C-F bond in perfluoroalkyl substances represents an emerging focus in organic chemistry. We report here a transition-metal-free intermolecular defluorinative cyclization of...
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Oxidative halogenation enabled by 2-haloethanol and aqueous H2O2 under metal-free conditions
Available online 9 October 2024
Electrophilic halogenation reactions have been recognized as robust approaches to accessing synthetically useful organohalides. Herein, we disclose an exclusive oxidative halogenation pathway, which...
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Sulfone as traceless activating group: Divergent synthesis of α-fluoroamides with C–F quaternary stereocenters
Available online 5 October 2024
A novel approach to α-fluoroamides bearing a C–F quaternary stereocenter is reported herein. With sulfone installed as the activating group, an alkyl group as well as a fluorine atom was introduced...
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Recent advances in photocatalytic C-H amination to nitrogenous structures
Available online 5 October 2024
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity, surpassing non-nitrogen architectures. Given the vast array of nitrogen-containing compounds...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
Available online 3 October 2024
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Mn2(CO)10-catalyzed direct protic hydrogen transfer with unactivated alkenes
Available online 26 September 2024
Transition-metal-catalyzed hydrogen-atom-transfer (HAT) reactions have proven to be effective strategies for obtaining important heterocycle scaffolds found in natural products. However, the electronic...
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Enhancement of CO2 hydrogenation to formate using formate dehydrogenase immobilized on UiO66 and its derivatives
Available online 23 September 2024
In the present work, a highly stable zirconium-based metal-organic framework (MOF), UiO66, and its derivative, UiO66-NH2, were tested as support materials to immobilize Formate dehydrogenase (FDH) for...
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Advances in the synthesis of C19-hydroxylated steroids
Available online 21 September 2024
The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets. This review...
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Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfur
Available online 18 September 2024
A novel method for the synthesis of 2,4-disubstituted thiophenes via the reactions of N,N-disubstituted enaminones and elemental sulfur is developed. By simply heating the substrates in pure water in...
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Photo-catalyzed dearomative coupling of benzylmalonates and alkynes with CO2 leading to spiro-1,4-cyclohexadiene carboxylic acids
Available online 17 September 2024
A dearomative coupling reaction of benzylmalonates and alkynes with CO2via visible-light catalysis is developed, leading to a series of spiro-1,4-cyclohexadiene carboxylic acids. This three-component...
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Advancing Sustainable Quinolines Synthesis via ZnIn2S4 Heterogeneous Photocatalysis
Available online 7 September 2024
In this study, we report a sustainable, visible light and heterogeneous photocatalytic system to address these issues, using the ternary sulfide ZnIn2S4 (ZIS) as a photoredox catalyst. Our protocol...
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Ate complexes in organic synthesis: From ate reagents to ate catalysts
August 2024
The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years, owing much to the evolution of ate complexes from mere reagents to versatile...
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