Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
Available online 19 December 2024
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
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Regioselectively electrochemical Csp3-H alkoxylation for functionalized indanone
Available online 13 December 2024
An electrochemical regioselective Csp3-H alkoxylation has been developed to synthesize functionalized 1-indanone. In this process, electricity serves as the formal terminal oxidant, while the molecular...
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The synthesis of multi-substituted benzazepine derivatives via Mn(III)-promoted oxidative annulation of isocyanides with boronic acids
Available online 10 December 2024
Seven-membered nitrogen-containing heterocyclic rings are important cores of anti-cancer, anti-antimicrobial, anti-malaria and other drugs. Therefore, efficient and expedient strategies for the synthesis...
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Modular trifluoromethylselenolation and fluoroalkylselenolation via Ag(I)-mediated selenium nitrogen exchange reaction of benzothiaselenazole-1-oxides
Available online 6 December 2024
By virtue of benzothiaselenazole-1-oxides as versatile building blocks and masked sulfoximines, we present a novel and practical trifluoromethylselenolation/fluoroalkylselenolation strategy via Ag(I)-mediated...
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Recent advances in (4 + 3) cycloaddition of allenes
November 2024
Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 + 3) cycloaddition reaction...
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Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies
November 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on carbonylation reactions have been published, summaries on cheap metal-catalyzed...
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Transition metal-free Csp3-Csp3 bond-forming reactions of N-tosylaziridines and gem-diborylalkanes
November 2024
The incorporation of additional Csp3 atoms into candidate drugs may enhance their pharmacological properties. Nevertheless, it remains challenging to construct desired Csp3-Csp3 bonds efficiently and...
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Visible-light induced photocatalyst-free difluoromethylation of quinoxalinones with difluorosulfones
November 2024
Visible-light induced direct C–H difluoromethylation of quinoxalinones with 2-((difluoromethyl)sulfonyl)benzo[d]thiazole has been developed for the first time. A broad range of quinoxalinones were well...
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Transition-metal and base-free ether synthesis via alcohol-participated yne-allylic substitution
November 2024
Ethers are among the most important chemicals in organic synthesis, the pharmaceutical industry, agrochemical production, and material science. C–O bond formation via substitution is one of the most...
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Electrochemical enabled desaturated β-C(sp3)-H sulfonylation and phosphonylation of cyclic amines
November 2024
Herein, we reported an efficient and straightforward method to realize desaturated β-C(sp3)-H sulfonylation and phosphonylation of cyclic amines driven by electrochemistry using catalytic amounts of...
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Pictet-spengler/transamination cascade reaction of indoles for modular synthesis of marinoquinoline analogues
November 2024
The Pictet-Spengler/transamination cascade reaction enables modular synthesis of marinoquinoline analogues through three-component indole ring-expansion/cyclization in the manner of novel N1–C2 cleavage...
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Development of a more efficient catalyst for the redox-neutral organocatalytic mitsunobu reaction by DFT-guided catalyst design
November 2024
The study of a Mitsunobu reaction is an important topic. Denton and co-workers first reported a novel (2-hydroxybenzyl)diphenylphosphine oxide for realizing the catalytic Mitsunobu reaction via a five-membered...
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Visible-light-induced radical-cascade alkylation/cyclization of N-methacryloyl-2-phenylbenzimidazole: Access to benzoimidazo[2,1-a]isoquinolin-6(5H)-ones
November 2024
A metal-free visible-light-induced synthesis of aza-polycyclic aromatic hydrocarbons via cascade alkylation/cyclization of N-methacryloyl-2-phenylbenzimidazole was developed. The reaction was carried...
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Photoinduced decatungstate-catalyzed direct coupling of cycloalkanes and cyclic aldimines
November 2024
We first describe a photoinduced decatungstate-catalyzed direct coupling of cycloalkanes and cyclic aldimines. The desired products were generated in moderate to good yields with wide substrate scope...
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Solvent-controlled stereodivergent synthesis of E- and Z-enamines via metal-free formal C(sp2)-H amination of α-substituted styrenes
November 2024
C(sp2)-H amination represents an attractive approach for the synthesis of enamines, which is intrinsically associated with the challenge of controlling of stereochemistry and primarily relying on transition-metal...
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Highly enantio-stereoselective Ni-catalyzed reductive cyclization to cyclopentanes with chiral quaternary centres of trisubstituted allylic siloxanes
November 2024
The construction of chiral quaternary carbon stereocenters is a significant challenge in asymmetric synthesis. Catalytic synthesis of these structures with trisubstituted allylic alcohols is highly...
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Electrocatalytic regio- and stereoselective carboxylation of terminal alkynes with CO2
Available online 30 November 2024
Carboxylation with CO2 is a practical and streamlined way to construct a variety of sophisticated carboxylic acids and their derivatives. However, a series of elegant methods focus mainly on C(sp3)–...
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TFA-Catalyzed cascade annulation of thioamides with aromatic hydrazides/amines: an internal oxidant-triggered protocol to diverse N-heterocycles
Available online 30 November 2024
An internal oxidant-triggered highly efficient protocol for the synthesis of diverse N-heterocycles (benzothiazoles, benzoxazoles, quinazolines, and 1,3,4-oxadiazoles) by TFA-catalyzed cascade annulation...
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Efficient one-pot synthesis of ruthenium catalysts and their role in optimizing sugar alcohol production: investigating structural sensitivity
Available online 30 November 2024
The study explores the feasibility of producing ruthenium catalysts supported on char through a one-pot synthesis, an original approach for the preparation of noble metal-based catalysts in this field....
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Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters
Available online 19 November 2024
In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic...
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Palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes: a strain release approach toward alkylidenecyclobutanes
Available online 16 November 2024
A palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes with amines is described. This protocol is featured with its novel activation model, broad substrate scope and mild reaction conditions,...
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A direct Ni-catalyzed deoxygenative Suzuki-Miyaura cross-coupling reaction of phenols via the formation of active O-phenyluronium
Available online 14 November 2024
Herein, we demonstrate that activation of phenols by tetramethylfluoroformamidinium hexafluorophosphate (TFFH) enables the establishment of the general Ni-catalyzed method for deoxygenative Suzuki-Miyaura...
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Advanced green synthesis: Solvent-free and catalyst-free reaction
Available online 9 November 2024
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Enhancing the catalytic efficiency of nitrilase for sterically hindered substrates by distal sites engineering
Available online 8 November 2024
Nitrilases are enzymes capable of converting nitriles into carboxylic acids under mild conditions. However, wild type nitrilases typically exhibit poor catalytic efficiency towards sterically hindered...
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Green solvent-controlled switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles
Available online 8 November 2024
The BF3·OEt2 promoted switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles from readily available feedstocks was developed by the adjustment of green solvents EA and...
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