Controllable stepwise fluorine elimination strategy for the chemodivergent synthesis of pyrido[2,1-a]isoquinolines
Available online 19 March 2025
A controllable stepwise fluorine elimination strategy has been reported, and used to selectively produce fluoro-substituted pyrido[2,1-a]isoquinolines and fluorine-free pyrido[2,1-a]isoquinolines through...
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Engineering glucose dehydrogenase from Sulfolobus sulfataricus toward utilizing diverse nicotinamide cofactor biomimetics
Available online 15 March 2025
Oxidoreductases are crucial for the production of widely utilized chiral building blocks, giving rise to a demand for costly NAD(P)/H. As potential substitutes for natural cofactors, nicotinamide cofactor...
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Chemoenzymatic two-step synthesis of tartaric acid employing glucose oxidase in combination with bimetallic AuPt/TiO2 catalyst
Available online 12 March 2025
Tartaric acid (TA) is a crucial hydroxy-carboxylic acid chelating agent extensively employed in the pharmaceutical, food, dye, and energy industries. The utilization of glucose oxidation for TA synthesis...
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Copper-catalyzed aerobic photodecarboxylation of carboxylic acids to aldehydes and ketones
Available online 12 March 2025
Base-metal-catalyzed decarboxylative transformations provide an economic pathway to the efficient functionalization of carboxylic acids. Herein, a copper-catalyzed aerobic photodecarboxylation of carboxylic...
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Enantioselective synthesis of chiral N-arylpyrroles through photoinduced desymmetrization
Available online 11 March 2025
The C–N axial chirality is widely present in natural products, bioactive molecules, and chiral ligands. Catalytic asymmetric construction of C–N axially chiral compounds is a challenging task due to...
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Biocompatible C-S bond construction for diarylmethyl thioethers
Available online 8 March 2025
We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs)...
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Visible light induced synthesis of the Benzoyl bioisosteres: bicyclo[1.1.1]pentane-ketone group
Available online 8 March 2025
Benzoyl groups are commonly found in the structures of various pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs), central nervous system stimulants, antihyperlipidemic agents,...
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Palladium-catalyzed ionic liquids-mediated cascade carbonylative alkynylation of diaryl ethers with alkynes
Available online 8 March 2025
An NHC-palladium-catalyzed ionic liquid-mediated cascade carbonylative alkynylation of diaryl ethers with alkynes in basic “task-specific” ionic liquid for the assembly of structurally diverse alkynones...
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Truce-smiles rearrangement mediated by ligand-to-iron charge transfer
Available online 6 March 2025
In this study, we utilized earth-abundant, inexpensive iron as a catalyst and inexpensive, abundant, readily available polyfluoroalkyl carboxylic acids as substrates for sulfone-group-retaining Truce-Smiles...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Sulfone as traceless activating group: Divergent synthesis of α-fluoroamides with C–F quaternary stereocenters
February 2025
A novel approach to α-fluoroamides bearing a C–F quaternary stereocenter is reported herein. With sulfone installed as the activating group, an alkyl group as well as a fluorine atom was introduced...
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Chemo- and diastereoselective four-component reactions with Rh carbynoids
February 2025
Multi-component reactions (MCRs) provide an efficient method for constructing multiple chemical bonds by combining three or more starting materials in a single operational step, enabling rapid and cost-effective...
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Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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One-pot access to indazole fused-phenanthridinones via Rh(III)-catalyzed [4+2] annulation
February 2025
An efficient synthesis of indazole fused phenanthridinones via Rh(III)-catalyzed inert C(sp2)-H activation/[4 + 2] annulation of 3-aryl-1H-indazoles with iodonium ylides has been developed, providing...
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Palladium-catalyzed intramolecular C–H arylation of ferrocenyl-sulfides, sulfoxide and its application in metal ion recognition
February 2025
An intramolecular C–H arylation of ferrocenyl ortho-bromophenyl sulfide and sulfoxide has been developed with a palladium/non-chiral monophosphine ligand. Under mild reaction conditions, a wide range...
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Highly efficient palladacycle-catalyzed carboxylation of benzyl alcohols
February 2025
A general and practical carboxylation of benzyl alcohols using the air- and moisture-stable Herrmann-Beller palladacycle was developed. With this novel methodology, numerous carboxylated products were...
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Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation
February 2025
The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities....
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Photo-mediated para-selective C(sp2)−H difluoroalkylations
February 2025
Photo-mediated ruthenium-catalyzed para-C−H difluoroalkylation has been disclosed under extremely mild conditions. This photochemical ruthenium catalyst system is characterized by good functional group...
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Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones
February 2025
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high...
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Brønsted acid-promoted synthesis of polysubstituted pyrroles from enamines/imines and diazopyruvates: A metal-free cascade approach
February 2025
A Brønsted acid-promoted, metal-free cascade reaction of easily available enamines/imines with diazopyruvates has been demonstrated. With triflic acid as the promoter, the reaction proceeds smoothly...
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Light-induced perfluoroalkylative carbonylation of unactivated alkenes with a recyclable photocatalyst
February 2025
The development of heterogeneous catalysis difunctionalization of olefins is of great significance because it can save costs in the industry. Here, we report the perfluoroalkyl carbonylation reaction...
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Divergent synthesis of new naphtho-fused 2-aminoindolines and naphthoxindoles based on straightforward construction of phenanthrene
February 2025
An environmentally friendly, highly atom-economical and operationally simple approach toward the synthesis of naphtho-fused 2-aminoindolines and naphthoxindoles starting from biaryl aldehydes and secondary...
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Accelerated flow synthesis of aripiprazole and brexpiprazole in environmentally benign solvents
Available online 22 February 2025
Aripiprazole and Brexpiprazole are both second-generation atypical antipsychotic medications to treat a wide range of psychiatric disorders, the retail sales of which reached $1.35 billion and $2.07...
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Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis
Available online 29 January 2025
A new type of asymmetric hydrogen atom abstraction catalysts, originated from the cinchona alkaloid family of natural products, has been successfully developed to access enantioselective epimerizations...
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Copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes
Available online 10 January 2025
Hydrophosphination of α,β-unsaturated carbonyl compounds is one of the most common methods to prepare chiral phosphines. Herein, a copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes...
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