Recent Articles

Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway

March 2025

Haixia Luo | Jingjing Chang | Yiting Ren | Xiu Zhang | Yuanxing Li | Miao Huo | Hongyuan Wang | Xin Yang | Jianbing Liu | Qingmei Zhang | Yueyang Zhao | Wei Wang

Mutational and transcriptional profiling of cuproptosis-associated genes in amyotrophic lateral sclerosis

January 2025

Di He | Xilu Wang | Meng Hao | Dongchao Shen | Xunzhe Yang | Mingsheng Liu | Yi Li | Jiucun Wang | Liying Cui

Epidermal second-hit mutation in MVK gene associated with linear porokeratosis

January 2025

Anqi Zhao | Xinyi Wang | Chaolan Pan | Yumeng Wang | Qiaoyu Cao | Min Li | Ming Li

Single-cell transcriptomics illustrates the immune inflammatory responses of septic mice spleen after capsaicin treatment

January 2025

Weijin Qiu | Qian Zhang | Jing Liu | Xueling He | Guangqing Cheng | Jiayun Chen | Yunmeng Bai | Piao Luo | Ping Gong | Fei Shi | Jigang Wang

Profiling the cell diversity and tissue structure of aqueous humor circulatory system in human eyes using spatial single-cell RNA sequencing

January 2025

Hao Yuan | Zhaona Song | Xiao Sun | Chunping Song | Lidong Guo | Qiang Zhang | Yonglun Luo | Chengfu Yuan | Jianlu Gao | Xiaodong Jia

Single-cell sequencing reveals the immune microenvironment associated with gastric cancer

January 2025

Guoquan Huang | Cheng Yuan | Chao Zhang | Fuyu Yang | Yong Tan | Defei Chen | Hui Li | Kun Qian

Single-cell sequencing revealed the microglia-activated cell distribution in gray matter heterotopia

January 2025

Penghu Wei | Chunhao Shen | Jinkun Xu | Quanlei Liu | Yihe Wang | Xiaotong Fan | Yongzhi Shan | Guoguang Zhao

Novel virulence-related genes that contribute to clinical infections of Salmonella enteritidis

January 2025

Bill Kwan-wai Chan | Ruichao Li | Edward Wai-chi Chan | Kwok-yin Wong | Sheng Chen

Analysis of mutations in Chinese patients with polycystic kidney disease by targeted exome sequencing

January 2025

Kaili Qin | Qian Wang | Jianbo Qing | Yaheng Li | Hao Gong | Zhijian Zha | Bingrui Zhou | Yafeng Li

Functional impact of the head domain variants of DES (Desmin) on filament assembly

January 2025

Sabrina Voß | Volker Walhorn | Stephanie Holler | Anna Gärtner | Greta Pohl | Jens Tiesmeier | Jan Gummert | Dario Anselmetti | Hendrik Milting | Andreas Brodehl

Establishment of a mouse model of respiratory mycoplasma challenged intranasally combined intraperitoneally eliciting chronic inflammation and lung consolidation

January 2025

Xing Xie | Yuan Gan | Maoda Pang | Lei Zhang | Fei Hao | Yanna Wei | Yi Chen | Rong Chen | Zhenzhen Zhang | Qingyun Xie | Daesub Song | Guoqing Shao | Maojun Liu | Qiyan Xiong | Zhixin Feng

Genetic feature diversity of KRAS-mutated colorectal cancer and the negative association of DNA mismatch repair deficiency relevant mutational signatures with prognosis

January 2025

Ruichuan Shi | Yu Cheng | Jin Wang | Na Song | Ying Chen | Zan Teng | Ling Xu | Yunpeng Liu | Xiaotian Zhao | Qiuxiang Ou | Peng Yang | Rui Ma | Yiting Sun | Jinglei Qu | Xiujuan Qu

Heterogeneity of anoikis in triple-negative breast cancer subtyping and therapeutic implications

January 2025

Kun Fang | Suxiao Jiang | Zhengjie Xu | Meng Luo | Changsheng Yan

CircAkap7: A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity

January 2025

Jiaqin Liu | Sa Liu | Xiangyun Li | Shanshan Wei | Taoli Sun | Ning Xie | Bikui Zhang | Wenqun Li

EBF1 expressed in the dermal papilla regulates hair type and length

January 2025

Hongzhi Song | Leslie Lei Zhang | Wei-qi Zhong | Eve Qian Chen | Xi-Xi Qiu | Zi-Ling Tang | Xin-Hua Liao

Time-series transcriptome analysis mapping pulmonary immune checkpoint atlas of experimental silicosis

January 2025

Youliang Zhao | Yuanmeng Qi | Meixiu Duan | Changfu Hao | Wu Yao

Prevalence of synonymous mutations in m6A modification sites in human cancers

January 2025

Richard Chen | Lu Yang | Li Han | Zunsong Hu | Zhaohui Gu | Xiaolan Deng

Identification of AAV serotypes for gene therapy in Krabbe iPSCs-derived brain organoids

January 2025

Yafeng Lv | Zhi Cui | Hongbo Li | Jing Wang | Mulan Wei | Yuanlang Hu | Xun Li | Chunyu Cao | Ye Zhang | Wei Wang

Integrating single-cell RNA sequencing and bulk RNA sequencing data to predict acute respiratory distress syndrome in sepsis patients

January 2025

Miao Wang | Xiaoer Jin | Qingbo Liao | Yufan Pu | Xiaowen Xu | Xiaoqiang Ren | Gaoqing Liu | Zhiwei Zhuang | Qi Ding

Recent advances in methylation modifications of microRNA

January 2025

Ning Su | Xiaohang Yu | Ming Duan | Ning Shi

microRNAs (miRNAs) are short single-stranded non-coding RNAs between 21 and 25 nt in length in eukaryotic organisms, which control post-transcriptional gene expression. Through complementary base pairing,...

The combination of SLC7A11 inhibitor and oridonin synergistically inhibits cervical cancer cell growth by decreasing the NADPH/NADP+ ratio

January 2025

Yajie Liu | Pengxing He | Xubin Ma | Yingqi Tian | Yu Zhang | Yang Wang | Yingjie Jia | Hongmin Liu | Ying Liu | Yichao Xu

NUF2 overexpression predicts poor outcomes in multiple myeloma

January 2025

Shanshan Zhang | Li Zhang | Linjing Cai | Huan Chen | Yuqi Wang | Youhai Yuan | Hanzhen Zhang | Xiaolei Wei

Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice

January 2025

Liying Shan | Xiaoxia Liao | Xiaoli Yang | Endong Zhu | Hairui Yuan | Jie Zhou | Xiaoxia Li | Baoli Wang

Naked cuticle homolog 2 (NKD2) has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor. The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism...