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ISSN: 2352-3042

CN: 50-1221/R

p-ISSN: 2352-4820

Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection

March 2025

Yiyao Jiang | Ming Chen | Zhongmin Xiong | Yufang Qin

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Triplet therapy overcomes 3rd-EGFR TKI-resistant EGFR-L858R/T790M/C797S in trans and in cis/L718Q mutation

March 2025

Kaibo Ding | Zhongsheng Peng | Yanjun Xu

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Reduction of Atp5b protects mice from diet-induced obesity

March 2025

Xiaohua Huang | Binting Qin | Zhengfeng Fang | Lianqiang Che | Yan Lin | Shengyu Xu | Yong Zhuo | Lun Hua | Xuemei Jiang | Mengmeng Sun | Hairui Wang | De Wu | Qingqiang Long | Bin Feng

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Actin polymerization regulates the osteogenesis of hASCs by influencing α-tubulin expression and Eg5 activity

March 2025

Tingyu Fan | Wenqing Liu | Rongmei Qu | Jinhui Zhu | Yulian Shi | Jiaxuan Liu | Xiangtian Li | Zhitao Zhou | Yunbing Chang | Jun Ouyang | Jingxing Dai

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TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERα expression in triple-negative breast cancer

March 2025

Shang Gao | Ping Sun | Zekun Wang | Yecheng Jin | Wenjie Sun | Xi Li | Ruonan Duan | Jiangxia Li | Qiji Liu

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Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma

March 2025

Shufan Zhang | Rong Jiang | Changguo Wang | Manqiu Yang | Tao Wang | Jianzhou Cui | Guangbin Li | Shaomu Chen | Moli Huang

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Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5% of 320 families with steroid-resistant nephrotic syndrome

March 2025

Ronen Schneider | Shirlee Shril | Florian Buerger | Konstantin Deutsch | Kirollos Yousef | Camille N. Frank | Ana C. Onuchic-Whitford | Thomas M. Kitzler | Youying Mao | Verena Klämbt | Muhammad Y. Zahoor | Katharina Lemberg | Amar J. Majmundar | Bshara Mansour | Ken Saida | Steve Seltzsam | Caroline M. Kolvenbach | Lea Maria Merz | Nils D. Mertens | Tobias Hermle | Nina Mann | Dalia Pantel | Abdul A. Halawi | Aaron Bao | Luca Schierbaum | Sophia Schneider | Daanya Salmanullah | Iddo Z. Ben-Dov | Itamar Sagiv | Loai A. Eid | Hazem Subhi H. Awad | Muna Al Saffar | Neveen A. Soliman | Marwa M. Nabhan | Jameela A. Kari | Sherif El Desoky | Mohamed A. Shalaby | Said Ooda | Hanan M. Fathy | Shrikant Mane | Richard P. Lifton | Michael J.G. Somers | Friedhelm Hildebrandt

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A novel metabolite-interacting protein (MIP)-based molecular subtyping construction and validation of IGFBP3 as a MIP-related oncogene in colorectal cancer

March 2025

Simeng Bao | Yongmin Li | Yu Liang | Jianxun Dai | Huolin Huang | Bin Ma

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Unique presentation of a novel gain-of-function mutation in MTOR

March 2025

Samira Slimani | Alex G.I. Gagnon | Simon V. Schreiber | Nicolas A.D. Bergeron | Ludwig Haydock | Sébastien Labonté | Marc-Étienne Huot | Alexandre P. Garneau | Guillaume Canaud | Paul Isenring

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The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma

March 2025

Jianhong Zhang | Chengyang Song | Xiuqin Feng | Qian Yu | Xueying Yang

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Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma

March 2025

Yueying Gao | Jinyang Yu | Zhi Li | Kefan Liu | Jiwei Pan | Ya Zhang | Yanlin Ma | Jiwei Zhang | Zhigang Liu | Yongsheng Li

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TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma

March 2025

Jingyao Dai | Su Liu | Yangyang Xie | Yixuan Wang | Xiyun Bian | Tian Yu | Tiantian Li | Linchuang Jia | Zhigang Zhao | Zhiqiang Liu | Xiaozhi Liu

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NOP56 promotes hepatocellular carcinoma progression through 2′-O-methylation

March 2025

Shuxin Yang | Juan Liu | Shengxin Luo | Wentao Wang | Jingxiang Xu

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BBOX1, LACC1, MMP7 and SSTR1 as common predictors in obesity and non-alcoholic fatty liver disease

March 2025

Chaoyuan Huang | Guoming Chen | Dongqiang Luo | Jiyuan Zheng | Nan Zhong | Danyun Li | Yang Luo | Peizhen Huang | Ning Wang | Yibin Feng | Yiyuan Zheng

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The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis

March 2025

Yang Liu | Feifei Song | Xianhuang Zeng | Siqi Yang | Zixu Zhai | Ze Wang | Wajeeha Naz | Tanzeel Yousaf | Junwei Sun | Yangjun Zhang | Ying Zhou | Mingxiong Guo | Yun-Bo Shi | Geng Tian | Guihong Sun

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PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma

March 2025

Yue Weng | Xiangyu Yan | Biying Chen | Zhouliang Bian | Yunhui Ge | Hong Lu | Shufang He | Jian Wu | Yong Chen | Ming Lei | Yanjie Zhang

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Newly identified intronic and known pathogenic point mutations in SLC34A3/NPT2c cause hereditary hypophosphatemic rickets with hypercalciuria

March 2025

Yujing Sun | Yuan Liu | Xiaoli Zhang | Ling Jiang

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Concurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions

March 2025

Hongrui Chen | Bin Sun | Lizhen Wang | Lei Chang | Zhang Yu | Wei Gao | Yajing Qiu | Hui Chen | Chen Hua | Xiaoxi Lin

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SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia

March 2025

Akhilesh Kaushal | Samrat Roy Choudhury

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Whole exome sequencing identifies KCNH7 variants associated with epilepsy in children

March 2025

Fan Wu | Xinna Ji | Mengxiao Shen | Peidi Cheng | Shuo Feng | Yanyan Gao | Wanting Liu | Jinxiao Chen | Shupin Li | Xue Zhang | Qian Chen

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Mutational and transcriptional profiling of cuproptosis-associated genes in amyotrophic lateral sclerosis

January 2025

Di He | Xilu Wang | Meng Hao | Dongchao Shen | Xunzhe Yang | Mingsheng Liu | Yi Li | Jiucun Wang | Liying Cui

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Epidermal second-hit mutation in MVK gene associated with linear porokeratosis

January 2025

Anqi Zhao | Xinyi Wang | Chaolan Pan | Yumeng Wang | Qiaoyu Cao | Min Li | Ming Li

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Single-cell transcriptomics illustrates the immune inflammatory responses of septic mice spleen after capsaicin treatment

January 2025

Weijin Qiu | Qian Zhang | Jing Liu | Xueling He | Guangqing Cheng | Jiayun Chen | Yunmeng Bai | Piao Luo | Ping Gong | Fei Shi | Jigang Wang

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Profiling the cell diversity and tissue structure of aqueous humor circulatory system in human eyes using spatial single-cell RNA sequencing

January 2025

Hao Yuan | Zhaona Song | Xiao Sun | Chunping Song | Lidong Guo | Qiang Zhang | Yonglun Luo | Chengfu Yuan | Jianlu Gao | Xiaodong Jia

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Single-cell sequencing reveals the immune microenvironment associated with gastric cancer

January 2025

Guoquan Huang | Cheng Yuan | Chao Zhang | Fuyu Yang | Yong Tan | Defei Chen | Hui Li | Kun Qian

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