Recent Articles

Clinically relevant variants detected in Chinese children with global developmental delay/intellectual disability: An exome-wide sequencing study

July 2025

Yimeng Qiao | Nan Lv | Tongchuan Li | Ye Cheng | Yunqian Li | Jiqiang Dong | Meimei Han | Yang Gu | Qing Shang | Qinghe Xing

GATA2 up-regulation restores androgen receptor chromatin association and advances darolutamide resistance in prostate cancer

July 2025

Tianyi Zhou | Chengtai Yu | Yali Han | Bin He | Qin Feng

Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization

July 2025

Jing Tong | Liang Zhang | Jing Bai | Cong Zhang

CRISPR/Cas9 screening reveals Zfp607b as a novel transcription factor regulating myogenesis

July 2025

Siyuan Liu | Wei Wang | Zishuai Wang | Chao Yan | Guohao Han | Weiwei Liu | Yuxing Huang | Wangchang Li | Shengsong Xie | Zhonglin Tang

IL-17 signaling pathway in SPP1+ macrophages drives digestive tract cancer progression

July 2025

Yihong Wei | Ying Xu | Yanqiong Zeng | Amin Zhang | Xiangling Xing | Wancheng Liu

Systematic pan-cancer analysis identifies DNASE2 as a potential prognostic marker and immunotherapeutic target for glioblastoma multiforme

July 2025

Jun Cao | Si Chen | Ping An | Xingqiang Wang | Xinru Xiao | Shichao Li | Ye Cheng

PTEN and novel TEK germline variants associated with the phenotypes of PTEN hamartoma tumor syndrome

July 2025

Hongrui Chen | Bin Sun | Yanchun Zhou | Chen Hua | Xiaoxi Lin

Epigenetic modulation of thyroid cancer metastasis and glycolysis through circSSU72-mediated ubiquitination of gamma-catenin and beta-catenin signaling

July 2025

Zeyu Zhang | Duntao Su | Xiangyuan Qiu | Lei Yao | Fada Xia | Xinying Li

A novel mutation in KDR is associated with retinal venous beading and cerebral cavernous malformation

July 2025

Xiaonan Zhuang | Yuqiao Ju | Gezhi Xu | Xin Huang

Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF144_07C) in Ganzhou, China

July 2025

Xiaoyi Zhang | Hongmin Cao | Yating Chen | Chaoxian Lian | Ting Zeng | Junjie Liu | Junzhi Su | Qian Gao | Fengxiu Zhu | Yuning Zhang | Dandan Huang | Yanheng Zhou | Xin Chen

ISG15 regulates auto-inflammation by modulating NF-κB signaling pathway

July 2025

Meiqi Hou | Chao Yuan | Xiaopei Zhou | Zhenxing Liu | Nianyi Sun | Jinze Li | Xianqin Zhang

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling

July 2025

Hang He | Yuchen Wen | Qingran Huo | Hanzhi Yu | Jingjing Liu | Wenyan Jin | Zhiqin Wang | Huaquan Wang | Zhigang Zhao | Zhigang Cai

Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis

July 2025

Sang-Hun Park | Sae-Young Won | Yong-Chan Kim

Identification of the underlying molecular mechanisms of primary biliary cholangitis and ulcerative colitis comorbidity

July 2025

Weijia Han | Ting Song | Qi Wang | Chunyang Huang

A causal association between immune cells and hypertrophic cardiomyopathy: A bidirectional Mendelian randomization study

July 2025

Fang He | Qiangzhong Pi | Jun Yang | Mengning Wan | Jiang Yu | Ding Yang | Yongzheng Guo | Xiaorong Li

Proteomic profiling of exosomes leads to the identification of a candidate biomarker for prostate cancer progression

July 2025

MyeongHoon Yeon | Ah Reum Lee | Youngbum Yoo | Won-Kyeong Kim | Hyeon-Bin Shin | Hae Un Kook | Soon-Cheol Ahn | Myunggon Ko | Inkyung Jung | Chan Young Park | Young-Kyo Seo

Arhgap29 deficiency causes EEC like syndrome in mice

July 2025

Dandan Chi | Yumeng Wang | Lili Yu | Wenyan Ruan | Beibei Zhang | Jian Ma | Xiaohong Duan | Yongqing Huang

Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II

July 2025

Irina A. Ishina | Anton P. Zhiyanov | Inna N. Kurbatskaia | Azad E. Mamedov | Stepan A. Nersisyan | Rustam H. Ziganshin | Igor E. Eliseev | Yunna S. Petrusenko | Anastasia V. Nikonova | Elizaveta S. Zhbanova | Maria A. Salnikova | Leyla A. Ovchinnikova | Ilgar Z. Mamedov | Alexey N. Davydov | Kamila S. Nurbaeva | Tatiana A. Lisitsyna | Tatiana M. Reshetnyak | Alexander M. Lila | Evgeniy L. Nasonov | Yakov A. Lomakin | Alexey A. Belogurov | Hongkai Zhang | Alexander G. Tonevitskiy | Yury P. Rubtsov | Alexander G. Gabibov | Maria Y. Zakharova

The MTMR11 variants identified in a short stature cohort compromise the dephosphorylation ability of MTM1 on SMAD5 to up-regulate BMP signaling

July 2025

Kai Yang | Hongdou Li | Rui Peng | Bo Wu | Yiping Shen | Tongjin Zhao | Chentao Li | Weimin Wang | Hongyan Wang

MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential

July 2025

Mei Tian | Yang Zhou | Yitong Guo | Qing Xia | Zehua Wang | Xinying Zheng | Jinze Shen | Junping Guo | Shiwei Duan | Lijun Wang

Adipose tissue fibrosis, characterized by abnormal extracellular matrix deposition within adipose tissue, signifies a crucial indicator of adipose tissue malfunction, potentially leading to organ tissue...

Nrf2: A key regulator in chemoradiotherapy resistance of osteosarcoma

July 2025

Xianglin Peng | Jing Feng | Han Yang | Ping Xia | Feifei Pu

Osteosarcoma (OS), frequently observed in children and adolescents, is one of the most common primary malignant tumors of the bone known to be associated with a high capacity for invasion and metastasis....

The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases

July 2025

Hemanyun Bai | Fanji Meng | Kangling Ke | Lingyan Fang | Weize Xu | Haitao Huang | Xiao Liang | Weiyan Li | Fengya Zeng | Can Chen

With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived...

GOT2: New therapeutic target in pancreatic cancer

July 2025

Jiarui Bu | Zeyu Miao | Qing Yang

In recent years, the incidence and mortality rates of pancreatic cancer have been steadily increasing, and conventional therapies have shown a high degree of tolerance. Therefore, the search for new...