Isovalerylglycine and α-Ketobutyrate are novel biomarkers that discriminate clear cell renal cell carcinoma in biopsy specimens using two-dimensional magnetic resonance spectroscopy
2023
Tumor heterogeneity and lack of pre-operative diagnostic biomarkers are key topics in the field of renal cell carcinoma (RCC) identification. Clear cell RCC (ccRCC) is an aggressive cancer subtype which...
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Probing biological network in concurrent carcinomas and Type-2 diabetes for potential biomarker screening: An advanced computational paradigm
2023
Type-2 diabetes mellitus (T2DM), the predominant form of diabetes in adults, is a co-morbid condition that exacerbates the severity of many other diseases, including cardiovascular disease, obesity,...
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Potential consequences of screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis using a novel biomarker, club cell protein-16, with possible intervention by repurposing metformin
2023
Earlier, a study conducted by the Indian Council of Medical Research – National Institute of Occupational Health (ICMR-NIOH), India, evidenced that CC16 may be used as a proxy marker and screening tool...
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Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study
2023
The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys®...
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Recombinant erythropoietin treatment improves serum podocyte marker levels in diabetic kidney disease
2023
Recombinant human erythropoietin (rHuEPO) is an effective treatment for renal anemia. Recently, there is evidence to suggest that rHuEPO may reduce podocyte injury in diabetic kidney disease (DKD)....
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Investigation of cystine as differential diagnostic biomarker between astrocytomas and oligodendrogliomas based on global- and targeted analysis using liquid chromatography/tandem mass spectrometric analysis
2023
Astrocytoma and oligodendroglioma are primary brain tumors classified as gliomas. Because there is difference in the prognostic significance of the extent of resection between IDH-mutant astrocytoma...
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Omicron’s intrinsic gene-gene interactions jumped away from earlier SARS-CoV-2 variants and gene homologs between humans and animals
2023
Omicron and its subvariants have become the predominant SARS-CoV-2 variants worldwide. The Omicron’s basic reproduction number (R0) has been close to 20 or higher. However, it is not known what caused...
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Taurine as a biomarker for aging: A new avenue for translational research
2023
The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels. It is also suggested that variations in the blood...
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Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases
2023
Diabetes mellitus (DM) is an array of metabolic diseases, which results from deregulation in insulin secretion or its action leading to abnormally high levels of blood sugar associated with long-term...
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Isolation and evaluation of significant antibacterial fraction of methanol and its derived fractions from the leaves extract of Zygophyllum simplex
2023
Food poisoning related to bacterial contamination is the most common disease and cause of death nowadays in developing countries. There are many plants that have made a revolution in the field of medicine....
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Therapeutic capability of selected medicinal plants' bioactive constituents against the mutant ovarian TP53 gene; a computational approach
2023
A mutant P53 protein plays such a crucial role in ovarian cancer, and natural compounds have been known to be effective in treating cancer. The current study was conducted to discover new mutant P53...
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Influence of deproteinization and demineralization process sequences on the physicochemical and structural characteristics of chitin isolated from Deep-sea mud shrimp (Solenocera hextii)
2022
Isolation of chitin from shrimp shell waste using chemical process is a well-adopted industrial practice due to its short process time and efficiency in removing both minerals and proteins from the...
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The antibacterial, antioxidant and anti enzymatic activities of the leaves’ crude extracts of Hyoscyamus gallagheri
2022
Oman is a diverse habitat for various rare medicinal plants. Hyoscyamus gallagheri (H. gallagheri), locally known as Zgaf, is one of those rare plants. It is traditionally used for different ailments....
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Genetic variations of vitamin D receptor gene and steroid receptors status in breast cancer risk: An updated review
2022
Breast cancer, the most predominant type of cancer reported in females, is a heterogeneous disease classified into various subcategories depending on the presence of hormone receptors. Epidemiological...
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Biomarkers of sequela in adult patients convalescing from COVID-19
2022
Different biomarkers for SARS-CoV-2 have been linked to detection, diagnosis, treatment, disease progression, and development of new drugs and vaccines. The objective of this research was to evaluate...
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Antioxidant and antibacterial activities of leaves crude extracts of Adenium obesum grown in Oman National Botanical Garden
2021
Globally, researchers are investigated and recommend that about two-thirds of the plant and marine species available have significant antioxidant and antibacterial activities. Plant reduce oxidative...
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Biomarker profiling of essential oil and its antibacterial and cytotoxic activities of Cleome austroarabica
2021
The primary role of plants and its products in the treatment of illness is demonstrated by their employment in all the major health care systems of medicine irrespective of the original philosophical...
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Chemical fingerprint of Centella Asiatica’s bioactive compounds in the ethanolic and aqueous extracts
2020
Centella asiatica is a herbal plant that is widely used as medicine due to the benefit of its bioactive compounds such as rutin, kaempferol, quercetin, gallic acid, luteolin and catechin. Typically,...
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Isolation, characterization and standardization of demineralization process for chitin polymer and minerals from the crabs waste of Portunidae segnis
2020
The most abundant polymeric compound in nature after cellulose is chitin. Mostly, it is used as raw material for food additives, agriculture, biomedicine, water treatment, cosmetics and textile industry....
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The role of obesity on chronic kidney disease development, progression, and cardiovascular complications
2020
The complex links between obesity, chronic kidney disease (CKD) and cardiovascular disease (CVD) are not completely understood. The objective of this review is to describe and discuss the anatomy, physiology,...
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Drug sensitivity testing, a unique drug selection strategy
2020
Cancer treatments become more effective now. One cause of these therapeutic promotions is based on drug selective paradigms in the clinic. A small range of drug selective paradigms (pharmacogenomics,...
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Biomarkers of COVID-19 and technologies to combat SARS-CoV-2
2020
Due to the unprecedented public health crisis caused by COVID-19, our first contribution to the newly launching journal, Advances in Biomarker Sciences and Technology, has abruptly diverted to focus...
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Bio-molecular characterization of stress enzyme profile on esterase in selected silkworm races of Bombyx mori (L.) for biomarker selection
2019
Silkworm Bombyx mori exhibits for eliminating pathogenic defenses by their secretory component of haemolymph and gut component. This study aimed to investigate the stress enzyme role of carboxyl esterase,...
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MicroRNAs and its emerging role as breast cancer diagnostic marker- A review
2019
Breast cancer causes severe mental stress on the affected woman during investigation, diagnosis and treatment as breast is regarded as a symbol of beauty, sexuality and motherhood. Over and above the...
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