Evaluation of toxicity and antioxidant activities of various crude extracts of leaves and stems of Zygophyllumsimplex
2025
Zygophyllum simplex (Z. simplex) is a plant that has been used for a long time for the treatment of human diseases. Therefore, this present research study aims to prepare various plant extracts and...
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Etiological connections between initial COVID-19 and two rare infectious diseases
2025
The origin of COVID-19 remains unclear despite extensive research. Theoretical models can simplify complex epigenetic landscapes by reducing vast methylation sites into manageable sets, revealing fundamental...
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Unraveling ankylosing spondylitis: Exploring the genetic and immunological factors and latest treatment innovations
2025
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis primarily affecting the spine and sacroiliac joints. Gut microbiota significantly affects ankylosing spondylitis (AS) pathophysiology....
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Bringing lab to the field: Exploring innovations in point-of-care diagnostics for the rapid detection and management of tropical diseases in resource-limited settings
2025
Tropical diseases present major health challenges in regions with limited resources, where access to advanced laboratory facilities is often scarce. This study explores the innovative techniques emerging...
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Application of Generative Adversarial Networks on RNASeq data to uncover COVID-19 severity biomarkers
2025
The COVID-19 pandemic has highlighted the need for reliable biomarkers to predict disease severity and guide treatment strategies. However, the analysis of RNASeq data for biomarker discovery using...
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“MiRNA based target identification of TNFα gene in nephrotic syndrome”
2025
Nephrotic syndrome (NS) can be caused by various underlying kidney conditions. In most cases, the exact cause of NS is unknown, although it may be related to the body's immune system malfunctioning....
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Genomic analysis identifies an incipient signature to forecast imatinib resistance before start of treatment in patients with chronic myeloid leukemia
2025
The unprecedented success of tyrosine kinase inhibitor (TKI), imatinib, to induce remission in 86 % of chronic phase (CP) patients of chronic myeloid leukemia (CML) is undermined by drug resistance....
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Clinical features and predictive model for invasive pulmonary fungal infections in hematologic disorders
2025
This study was to investigate the clinical features of hematological disorders complicated by invasive pulmonary fungal infections and identify factors affecting treatment outcomes, with the aim of...
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A mini review: Role of novel biomarker for kidney disease of future study
2025
In the world, kidney disease is most common cause of death. Primary care physicians must conduct appropriate diagnosis, and management in order to avoid detrimental consequences linked to death as well...
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Procalcitonin and C-reactive protein as alternative salivary biomarkers in infection and inflammatory diseases detection and patient care: A scoping review
2025
In ambulatory and hospital settings, inflammatory diseases stand a significant challenge for both patients and clinicians. These conditions, often serve as precursors to sepsis, necessitate effective...
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Biomarkers in immunology: Their impact on immune function and response
2025
The immune system is a complex network of organs, tissues, and cells that plays a critical role in defending the body against life-threatening diseases such as infections, cancer, Alzheimer's, and Crohn's...
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CAR-T and nanotechnology: A comparative Perspective on autoimmune disease and cancer
2025
Nanotechnology has emerged as a key transformative force in upgrading Chimeric Antigen Receptor T-cell (CAR-T) from generation to generation in cancer and autoimmune treatment. Nanotechnology-aided...
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Investigations of solid waste biosorbents for eliminations of total hardness from water: An experimental study of conversion of waste into valuable products
2025
Hard water is a serious problem in the village areas. Alkaline hardness can cause eye pain, respiratory tract collapse, liver difficulties, and skin concerns. Human biological hardness after the extreme...
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Investigation of the effects of polyherbal formulations against the combination of a high-fat cafeteria diet along with exercise modalities
2024
The aim of the present study was to make a polyherbal formulation of three herbs that would offset the negative effects of the high-fat cafeteria diet on rats and the beneficial effects of exercise....
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Isolation and characterization of cytotoxic and antioxidant biomarkers from the aerial parts of Suaedaaegyptica
2024
Chronic disease is an irregular change inside or outside of the tissues and organs that results in accumulation, local damage, and inflammation or irritation. Suaeda aegyptiaca (S. aegyptiaca) is a...
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Faecal microbial transplant
2024
Faecal Microbial Transplantation (FMT), have been shown to be successfully managed along with a variety of gastrointestinal disorders, including Clostridioides difficile infection (CDI), inflammatory...
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Paper based molecularly imprinted SERS substrate for early detection of lysophosphatidic acid in ovarian cancer
2024
The current study is related to fabrication of point-of-care molecularly imprinted paper-based analytical devices, specifically related to ovarian cancer early stage detection. The task involves creating...
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A brief history of urine examination - From ancient uroscopy to 21st century urinomics
2024
The art of uroscopy (Greek ouron-urine and skopeo-examination), the visual inspection of urine, is as old as the history of mankind. It had seen its ups and downs, was praised and derided, but was ultimately...
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Patient-derived primary culture-based prognostic model to predict tumor recurrence in patients with glioma
2024
The prognosis for glioma patients remains grim despite aggressive treatment approaches. Current molecular profiles have limitations in predicting glioma recurrence, highlighting the need for new and...
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Transforming early microbial detection: Investigating innovative biosensors for emerging infectious diseases
2024
The recent global pandemic has highlighted an increase in the prevalence of communicable diseases caused by pathogens. The swift transmission of these diseases within a short timeframe presents a substantial...
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Matrix metalloproteinase 7 as a diagnostic biomarker of biliary atresia: A systematic review
2024
Biliary atresia (BA) is a disease of the intrahepatic or extrahepatic bile ducts with an unknown etiology. It presents in neonates with jaundice, clay-colored stool, and often hepatomegaly. Early diagnosis...
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Inflammation-induced cellular changes: Genetic mutations, oncogene impact, and novel glycoprotein biomarkers
2024
Persistent inflammation can trigger the development of colorectal cancer, especially in patients with inflammatory bowel disease (IBD). The precise molecular mechanisms underlying this process are not...
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Nanomedicine in cancer therapy: Advancing precision treatments
2024
The progress made in the field of nanotechnology has resulted in the development of nanomedicine agents, which have demonstrated their efficacy as a promising clinical tool in the fight against different...
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A systematic study on key Epigenetic modulators in post-stroke conditions
2024
A stroke is a medical emergency characterized by the sudden interruption of blood flow to the brain, leading to cell death from oxygen deprivation. As a leading cause of mortality and long-term disability...
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Leveraging lean 4.0 technologies in healthcare: An exploration of its applications
2024
Lean 4.0, a fusion of lean manufacturing and digital technologies, is a powerful tool for implementing Industry 4.0. Its widespread use across sectors is driven by its ability to eliminate waste, reduce...
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