Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair
June 2024
•Developed a magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating material structure with magnetic stimulation for spinal cord regeneration.•Demonstrated that medium-intensity magnetic...
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The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus: Past, Present and Future Designs for an Emerging Surgical Solution
June 2024
•Nucleus pulposus replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs (IVDs).•Review of pathologies treated with this technology,...
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Microalgae-based drug delivery system for tumor microenvironment photo-modulating and synergistic chemo-photodynamic therapy of osteosarcoma
June 2024
•A natural photosynthetic microalgae (C. vulgaris) was used as drug carriers loaded with chemotherapeutic doxorubicin to develop a multifunctional therapeutic platform (CV@DOX) for tumor microenvironment...
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Flexible wearable sensors: An emerging platform for monitoring of bacterial infection in skin wounds
June 2024
•We introduced the distribution of bacteria in wound infections.•We summarized current methods for bacterial detection in wounds.•We discussed three kinds of flexible wearable sensors for bacterial...
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Emerging microfluidics for the modeling and treatment of arthritis
June 2024
•Arthritis is a general term for a variety of joint diseases, seriously affecting people's physical and mental health.•Microfluidic is a technology that allows the precise control of fluid in a micro-channel.•In...
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LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma
June 2024
•High mobility group box 1(HMGB1) high expressed in laryngeal cancer tissues.•Knockdown of HMGB1 expression in laryngeal squamous cell carcinoma (LSCC) cells significantly suppressed the malignant phenotype...
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The role of gut microbiota associated metabolites in digestive disorders
June 2024
•Gut microbiota is closely linked to the body through its metabolites.•Gut microbiota metabolites participate in digestive system stabilization.•Gut microbiota metabolites affect the inflammatory bowel...
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The role of Piezo1 and Piezo2 proteins in tissue engineering: A Comprehensive review
June 2024
•Piezo1 and Piezo2 are the two novel mechanosensitive ion channels found in humans.•Piezo's are a sizeable trimeric protein with a three-bladed, propeller-like structure.•Two models- ‘Force from filament’...
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Targeted delivery of factors and cells for improving cardiac tissue regeneration and heart function following myocardial infarction
June 2024
•Sequential delivery of cytokines, growth factors and cells improved cardiac tissue repair.•IL-10, TGF-β/VEGF-A, FGF-2 loaded into a chitosan-based cryogel exerted a synergistic effect.•Cryo/GF/Cells...
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Modelling the development of biological structures displaying longitudinal geometries in vitro: culturing pluripotent stem cells on plasma-treated, growth factor-coupled polycaprolactone fibres
March 2024
•We have taken a biomimicry approach to generate complex longitudinal structures in vitro using pluripotent stem cells cultured on plasma-immersion ion implantation (PIII)-treated polycaprolactone (PCL)...
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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency
March 2024
•Simplified process: The AgSNP@CD was prepared through a simplified process, making it amenable to large-scale production.•Portable and stroage: AgSNP@CD maintains structural integrity after compression,...
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Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis
March 2024
•It is a huge challenge to one-step repair the load-bearing large segmental bone defects due to the insufficient structural stability of Ca-phosphate bioceramics.•Customized magnesium-doped wollastonite/β-TCP...
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PETG: Applications in Modern Medicine
March 2024
•PETG is a miscible, transparent thermoplastic with strong tensile properties, high ductility, and favorable resistance to heat and chemical insults.•PETG is an inexpensive and versatile biomaterial.•3D...
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Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering
March 2024
•This review outlined hierarchical structures of bone matrix spanning from nanoscale to macroscale.•This study discussed materialistic components of scaffolds and featured scaffold strategies.•This...
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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure
March 2024
•The fully human tissue-derived adhesive materials enable significant suppression of inflammatory cytokine storms, which breaks the limitations of existing strategies for organ repair based on the molecular...
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Microenvironment-responsive nanosystems for osteoarthritis therapy
March 2024
•This review underscores the intricate nature of OA, and emphasizes the challenge of comprehending its pathogenesis which have hindered the development of targeted therapies and precision medicine for...
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Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour
March 2024
•Tanycte-derived stem/progenitor cells cultured in vitro spontaneously differentiate.•Fiber properties can be controlled during manufacture to introduce aligned fibers.•Tanycyte-derived neurospheres...
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Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages
March 2024
•We applied pulsed electromagnetic field (PEMF) stimulation on nerve cells.•We screened different parameters and found the optimal ones to improve neurite outgrowth.•The same parameters had anti-inflammatory...
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Applications of silk-based biomaterials in biomedicine and biotechnology
March 2024
•Here, we reported the various unique properties of silk and commercially available silk-based biomaterials.•This review focused on highlighting various biomedical applications of silk-based biomaterials...
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Heterogenous glucose-stimulated insulin secretion at single islet level
December 2023
•Using single-islet-on-a-chip platform, three types of islets have been identified based on their dynamic GSIS.•High expression of Atp5pb is anti-correlated with the first phase of insulin secretion.•Diabetic...
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Strategies for engineering neural cell alignment and their biomedical applications
December 2023
•Proper alignment is essential for neural cells.•A variety of bioengineering methods have been employed to promote neural cell alignment.•Proper alignment of neural cells benefit nerve injury regen...
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Engineered artificial skins: Current construction strategies and applications
December 2023
•Give a detailed introduction of the cellular components, scaffold materials and bio-fabrication techniques involved in the construction of artificial skin.•Highlight the application for chronic wound...
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Driving modes and characteristics of biomedical micro-robots
December 2023
•Overview of driving mechanisms for micro-robots.•The autonomous micro-robots are mainly divided into chemically actuated micro-robots and biohybrid micro-robots.•The responsive micro-robots are controlled...
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