Bio-conversion of organic wastes towards polyhydroxyalkanoates
2023
The bio-manufacturing of products with substantial commercial value, particularly polyhydroxyalkanoates (PHA), using cost-effective carbon sources through microorganisms, has garnered heightened attention...
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Circular mRNA: A novel therapeutic agent
2023
Circular mRNA (circmRNA) is a covalent closed loop formed by reverse splicing of the 3′ end to the 5′ end of mRNA. Compared to traditional linear mRNAs, circmRNAs can mediate efficient, stable, and...
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2023 The 1st National Competition of “Bloomag Cup” in CO2 capture, conversion, and utilization
2023
The inaugural National Competition for Carbon Dioxide Capture, Conversion and Utilization Innovation (“Bloomag Cup”) was successfully held on July 30, 2023 in Beijing. This competition was initiated...
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Dual-plasmid interactions stimulate the accumulation of valencene in Saccharomyces cerevisiae
2023
Plasmids are one of the most commonly used basic tools in the construction of microbial cell factories, the use of which individually or in pairs play an important role in the expression of exogenous...
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SynBio Africa's story from the grassroots, the present, and the future
2023
SynBio Africa is a forum for researchers, students, citizen scientists, policymakers and the public to convene and develop successful pathways for the propagation of synthetic biology technologies,...
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Decoding dye degradation: Microbial remediation of textile industry effluents
2023
The extensive use of chemical dyes, primarily Azo and anthraquinone dyes, in textiles has resulted in their alarming release into the environment by textile industries. The introduction of heavy metals...
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Rational engineering approaches for establishing insect olfaction reporters in yeast
2023
Insect olfaction directly impacts insect behavior and thus is an important consideration in the development of smart farming tools and in integrated pest management strategies. Insect olfactory receptors...
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Suitability evaluation of toehold switch and EXPAR for cell-free MicroRNA biosensor development
2023
The development of a robust and cost-effective sensing platform for microRNA (miRNA) is of paramount importance in detecting and monitoring various diseases. Current miRNA detection methods are marred...
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Synthetic microbes and biocatalyst designs in Thailand
2023
Furthering the development of the field of synthetic biology in Thailand is included in the Thai government's Bio-Circular-Green (BCG) economic policy. The BCG model has increased collaborations between...
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Metabolic engineering of Escherichia coli to utilize methanol as a co-substrate for the production of (R)-1,3-butanediol
2023
Due to its abundance, cost-effectiveness, and high reducibility, methanol has gained considerable attention in the biomanufacturing industry as a nonfood feedstock for the production of value-added...
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Over-expression of α-bisabolene by metabolic engineering of Yarrowia lipolytica employing a golden gate DNA assembly toolbox
2023
Yarrowia lipolytica is a modern workhorse for biotechnology that is amenable to genetic manipulations and can produce high levels of various enzymes. The present study was designed to engineer Y. lipolytica...
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Harnessing gut cells for functional insulin production: Strategies and challenges
2023
Reprogrammed glucose-responsive, insulin + cells (“β-like”) exhibit the potential to bypass the hurdles of exogenous insulin delivery in treating diabetes mellitus. Current cell-based therapies-transcription...
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Cell-free synthetic biology: Orchestrating the machinery for biomolecular engineering
2022
Due to inherent complexity, incompatibility, and variability in living cell systems, biomolecular engineering faces significant obstacles. To find novel solutions to these issues, researchers have turned...
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Model-based dynamic engineering of Escherichia coli for N-acetylglucosamine overproduction
2022
N-acetylglucosamine (GlcNAc), a glucosamine derivative, has a wide range of applications in pharmaceutical fields, and there is an increasing interest in the efficient production of GlcNAc genetic engineered...
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Construction of an ultra-strong PtacM promoter via engineering the core-element spacer and 5′ untranslated region for versatile applications in Corynebacterium glutamicum
2022
As one of the most important synthetic biology elements in transcriptional regulation, promoters play irreplaceable roles in metabolic engineering. For the industrial microorganism Corynebacterium glutamicum,...
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Following the organism to map synthetic genomics
2022
Synthetic genomics, or engineering biology at the level of whole genomes and whole organisms, is an emerging outgrowth of parts-based synthetic biology. This nascent subfield is also diverse and difficult...
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Coupled synthetic pathways improve the production of 3-hydroxypropionic acid in recombinant Escherichia coli strains
2022
To improve the production of 3-HP with glucose as a substrate, the malonyl-CoA and propionyl-CoA pathways were coupled to regulate NADP+/NADPH regeneration in the recombinant E. coli. The strain Ec-AM...
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MvaT negatively regulates pyocin S5 expression in Pseudomonas aeruginosa
2022
Regulatory mechanisms that direct the synthesis and release of pyocin S5, a surface-acting bacteriocin produced by Pseudomonas aeruginosa, are relatively unknown. This study aims to identify transcription...
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Ribosome purification from Escherichia coli by ultracentrifugation
2022
With more and more researchers conducting extensive research on all aspects of ribosomes, how to extract ribosomes with good effect and high activity has become a fundamental problem. In this article,...
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Synthetic biology landscape and community in Germany
2022
Despite its start in the early 2000s, synthetic biology is still overall perceived as a young discipline. In some countries, such as the US, synthetic biology is academically and industrially established,...
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De novo synthesis of synthetic biology ecosystem in Slovakia: Challenges and opportunities
2022
Synthetic biology is an engineering discipline that applies engineering principles to rationally design novel biological systems. It has the potential to contribute to solving major global challenges...
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Development of destabilized mCherry fluorescent proteins for applications in the model yeast Saccharomyces cerevisiae
2022
Fluorescent proteins are widely used molecular reporters in studying gene expression and subcellular protein localization. To enable the monitoring of transient cellular events in the model yeast Saccharomyces...
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Micelle morphology observation method of lipopeptide by negative-staining-based transmission electron microscopy
2022
Lipopeptides, novel biosurfactants showing versatile promising applications in enhanced oil recovery, textile industry, agriculture and daily chemical products, etc., are profoundly highlighted recently....
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