Organ-on-chip technology: Opportunities and challenges
2024
Organ-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes....
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Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles
2024
Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs,...
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Understanding virus retention mechanisms on protein a chromatography based on using different wash buffers – Evaluating the possibility for a generic wash buffer toolbox to improve virus clearance capacity
2024
During manufacturing of mammalian-cell derived monoclonal antibodies (mAbs) virus clearance capacity of the downstream process has to be demonstrated. The protein A chromatography step typically achieves...
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A comprehensive study on anaerobic digestion of organic solid waste: A review on configurations, operating parameters, techno-economic analysis and current trends
2024
The excessive discharge and accumulation of solid organic waste into the environment is of severe concern across the globe. Thus, an efficient waste management system is important to mitigate health...
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Antibiotic susceptibility and virulence factors of bacterial species among cancer patients
2024
Antibiotic resistance is one of the most significant challenges of the 20-s century, and the misuse of antibiotics is a driver of antimicrobial resistance. This study aimed to assess the prevalence...
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The potential of copper oxide nanoparticles in nanomedicine: A comprehensive review
2024
Nanotechnology is a modern scientific discipline that uses nanoparticles of metals like copper, silver, gold, platinum, and zinc for various applications. Copper oxide nanoparticles (CuONPs) are effective...
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Unraveling current breakthroughs in Scorodocarpus borneensis phytochemical therapeutics: A systematic review
2024
Scorodocarpus borneensis, also known as the Kulim tree or Garlic tree, has been consumed by the local communities in Southeast Asia as traditional spice using its old leaves, stem bark, and seeds. The...
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CRISPR/Cas9 improves targeted knock-in efficiency in Aspergillusoryzae
2024
Aspergillus oryzae is an important fungus in food and industrial enzyme production. In A. oryzae, targeted knock-in transformation is primarily limited to homologous recombination (HR)-based systems,...
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Incorporating omics-based tools into endophytic fungal research
2024
Fungal endophytes are valuable sources of bioactive compounds with diverse applications. The exploration of these compounds not only contributes to our understanding of ecological interactions but also...
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Identifying Chlorella vulgaris and Chlorella sorokiniana as sustainable organisms to bioconvert glucosamine into valuable biomass
2024
Chitin is a major component of various wastes such as crustacean shells, filamentous fungi, and insects. Recently, food-safe biological and chemical processes converting chitin to glucosamine have been...
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Engineered microbial consortia for next-generation feedstocks
2024
Addressing urgent environmental challenges, this commentary emphasizes the need for green, bio-based solutions in chemical production from renewable feedstocks. It highlights advanced metabolic engineering...
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Unlocking the potential of biosurfactants: Innovations in metabolic and genetic engineering for sustainable industrial and environmental solutions
2024
Biosurfactants, synthesized by microorganisms, hold potential for various industrial and environmental applications due to their surface-active properties and biodegradability. Metabolic and genetic...
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aXonica: A support package for MRI based Neuroimaging
2024
Magnetic Resonance Imaging (MRI) assists in studying the nervous system. MRI scans undergo significant processing before presenting the final images to medical practitioners. These processes are executed...
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Mevalonate secretion is not mediated by a singular non-essential transporter in Saccharomyces cerevisiae
2024
Isoprenoids are highly valued targets for microbial chemical production, allowing the creation of fragrances, biofuels, and pharmaceuticals from renewable carbon feedstocks. To increase isoprenoid production,...
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Screening, characterization, and production of Bacillus cereus (S55) bioflocculant isolated from soil for application in wastewater treatment
2024
This research evaluated a bacterial strain, Bacillus cereus (S55), isolated from the soil for its bioflocculant production capabilities. The strain was identified through morphological and 16s rRNA...
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Advancements in Surface Plasmon Resonance Biosensors: A Comprehensive Review of Technologies, Applications, and Future Prospects
Available online 16 November 2024
Surface plasmon resonance (SPR) sensors have become widely used in various applications, including sensing, real-time chemical interactions, and other diverse purposes. Over the past few decades, SPR...
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Biotechnology Notes: A Year of Milestones
Available online 15 November 2024
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The future of cell-free synthetic biology
Available online 9 November 2024
Cell-free synthetic biology aims at the targeted replication, design, and modification of life processes in open systems by breaking free of constraints such as cell membrane barriers and living cell...
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Fine-tuning the cell morphology of Corynebacterium glutamicum via dual-valve regulation for enhanced hyaluronic acid production
2023
Enhanced synthesis of hyaluronic acid (HA) with recombinant Corynebacterium glutamicum as production host was achieved in this work. Hyaluronan synthase (HAS), which is a membrane protein acting as...
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Characterization and bioactive component analysis of filamentous bacterium XJ-16
2023
Actinomycetes, which can produce a variety of bioactive compounds in the metabolic process, is one of the important sources of novel drugs, enzymes, anti-tumor drugs and enzyme inhibitors. It has been...
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A facile microfluidic chip design for DNA detection using dengue serotypes as a proof-of-concept case study
2023
Dengue fever is caused by any of the four serotypes of dengue viruses, DENV-1, DENV-2, DENV-3 and DENV-4 spread by mosquito bites and is important to distinguish between them due to lack of cross-protective...
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The electrical transport and antibacterial properties of Fe doped MgO nanoparticles synthesized by a soft chemical technique
2023
Fe doped MgO nanoparticles were synthesized using a straightforward soft chemical method. We conducted a comprehensive examination of the electrical properties of Fe-doped MgO nanoparticles with a crystalline...
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Synthetic biology in Indonesia: Potential and projection in a country with mega biodiversity
2023
Synthetic biology has gained many interest around the globe in the last two decades, not only due to its rapid development but also the potential to provide addressable solutions using standardized...
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Potential application of menadione for antimicrobial coating of surgical sutures
2023
Staphylococcal-associated surgical site infections (SSI) are common nosocomial infections in healthcare facilities worldwide. The use of antiseptic-coated sutures has been recommended to minimise the...
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