Application of nucleic acid signal amplification in biosensing and bioimaging
March 2024
Nucleic acid amplification techniques are broadly employed in nucleic acid testing due to their efficient accumulation of nucleic acid sequences. With the development of biotechnology, they are further...
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Characterization of aggrephagy-related genes to predict the progression of liver fibrosis from multi-omics profiles
March 2024
Liver fibrosis is recognized as a consequence of persistent liver damage. Hence, understanding the mechanisms of liver fibrosis could help patients reverse this process. Aggrephagy is a selective type...
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Bone regeneration and antibacterial properties of calcium-phosphorus coatings induced by gentamicin-loaded polydopamine on magnesium alloys
March 2024
Improving the corrosion resistance, osteogenic activity, and antimicrobial capacity of the magnesium-based implant is considered the key to promoting their large-scale clinical application. In this...
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Applications of 3D printing in tumor treatment
March 2024
As an emerging technology relevant to materials science, 3D printing technology simplifies material production process, shortens the preparation cycle, and provides a broader space for disease treatment....
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Functional hydrogels for treatment of dental caries
March 2024
As the most popular teeth problem, dental caries can result in pain, suffering, impaired function, and diminished quality of life among communities, which calls for new strategies to improve the therapeutic...
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A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research
December 2023
Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group...
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Overcoming melanoma resistance to immune checkpoint blockade therapy using nano-strategies
December 2023
Monoclonal antibodies targeting CTLA-4, PD-1/PD-L1 axis, and LAG-3, have shown unprecedented clinical success in melanoma. However, such immune checkpoint blockade (ICB) therapies failed to initiate...
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A comprehensive review on carbon quantum dots as an effective photosensitizer and drug delivery system for cancer treatment
December 2023
Carbon quantum dots (CQDs) are an emerging class of carbon-based nanomaterials. CQDs are receiving considerable interest in biomedical applications due to their low toxicity, stability profile, efficient...
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Developing engineering technologies for the treatment of systemic lupus erythematosus
December 2023
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs and tissues. However, only a handful of new drugs have been FDA-approved for SLE since the 1950s. Therefore,...
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Precisely integrated contact lens: An intraocular pressure guard for glaucoma patients
December 2023
Recently, scientists at Pohang University of Science and Technology in South Korea constructed a smart theranostic contact lens. The highly integrated smart contact lens is composed of an intraocular...
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Exosomes-based particles as inhalable COVID-19 vaccines
December 2023
Coronavirus disease 2019 (COVID-19), a severely spreading pandemic, has dramatically brought physiological and economical burdens to people. Although the injectable vaccines have some achievements for...
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Exploring the revolution in healthcare systems through the applications of digital twin technology
December 2023
Digital Twin is a virtual replica of an item that is gaining traction in several sectors. This technology is creating significant advancements in the field of healthcare. A machine or a person's digital...
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Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery
September 2023
In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize...
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Ignored roles of gases in digestive diseases
September 2023
Complexities of the intestine have brought enormous controversy and discussions to the research on the digestive diseases. The neglected gas environment is crucial in shaping the dynamic intestinal...
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Advance in oral delivery of living material
September 2023
Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from...
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Recent advances in Fenton and Fenton-like reaction mediated nanoparticle in cancer therapy
September 2023
Fenton and Fenton like reaction have been well clarified as efficient reactive oxygen species (ROS) sources in tumor, and have been widely developed into a cancer treatment method. Meanwhile, transition...
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Investigations of robotics and laparoscopy in minimally invasive hepatectomy
September 2023
The concept of minimally invasive liver surgery has been widely accepted due to the advantages of fast recovery. Robotic hepatectomy is different from laparoscopic hepatectomy due to its fixed joint...
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KRT17 serves as an oncogene biomarker of poor survival in patients with hepatocellular carcinoma
September 2023
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death from worldwide. Thus, it is imperative to clarify valuable diagnostic and prognostic biomarkers for early-stage HCC. The expression...
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