Bioprinting of Alginate-Norbornene bioinks to create a versatile platform for kidney in vitro modeling
July 2025
Chronic kidney diseases affect a significant portion of the global population and their prevalence is expected to increase in the coming years. Advanced in vitro models are crucial for understanding...
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Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls
July 2025
Vascular injury and some chronic ischemic lesions usually lead to insufficient blood supply to tissues, which will lead to tissue ischemia or even necrosis in severe cases. Current artificial blood...
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Artificial multienzyme nanoflower composite hydrogel for efficiently promoting MRSA-infected diabetic wound healing via glucose-activated NO releasing and microenvironment regulation
July 2025
Diabetic wound repair is a global challenge due to bacterial infection and the typical microenvironments of hyperglycemia, high pH value, hypoxia, persistent inflammation and insufficient angiogenesis....
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Minimally invasive snakebite inspired microneedle delivery system for internal organs
July 2025
Efficient distribution of therapeutics to the targeted site, particularly internal organs, is essential for their therapeutic success. Here, we developed a therapeutic delivery system targeting internal...
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Continuous mechanical-gradient hydrogel with on-demand distributed Mn2+/Mg-doped hydroxyapatite@Fe3O4 for functional osteochondral regeneration
July 2025
Traditional layered gradient scaffolds are susceptible to delamination owing to abrupt stress alterations, thereby rendering them inefficacious for the integrated repair of osteochondral defects. This...
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Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration
July 2025
Large-gap peripheral nerve injuries (PNI) are often treated with autografts, allografts, or synthetic grafts to facilitate nerve regeneration, but these options are often limited in their availability...
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Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration
July 2025
Cyclodextrins (CDs), characterized by their unique cyclic oligosaccharide structure and exceptional capacity for molecular encapsulation through host-guest interactions, have garnered significant attention...
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Multifunctional nanoparticles and collagenase dual loaded thermosensitive hydrogel system for enhanced tumor-penetration, reversed immune suppression and photodynamic-immunotherapy
June 2025
Breast cancer is the most prevalent and lethal malignancy among females, with a critical need for safer and less invasive treatments. Photodynamic therapy (PDT) can effectively eliminate tumor cells...
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Evaluation of FeMnN alloy bioresorbable flow diverting stents in the rabbit abdominal aorta
June 2025
Flow diverting stents are braided, metallic endoluminal devices widely used to treat intracranial aneurysms. Bioresorbable flow diverters (BRFDs) are gaining traction as the next generation of flow...
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MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction
June 2025
Regeneration therapeutic strategy by microRNAs for boosting cardiomyocyte proliferation in treating myocardial infarction (MI) has the challenges of efficient delivery, and toxicity and risk of sudden...
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Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery
June 2025
The persistence of bacteria in the root canal system is the primary cause of recurrent apical periodontitis. The adaptability of residual bacteria to changing environmental conditions is a key survival...
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Designer mammalian living materials through genetic engineering
June 2025
Emerging genome editing and synthetic biology toolboxes can accurately program mammalian cells behavior from the inside-out. Such engineered living units can be perceived as key building blocks for...
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3D-printed PCL scaffolds combined with injectable sodium alginate/magnesium-doped mesoporous bioactive glass nanosphere hydrogel for meniscus regeneration: In vitro, In vivo, and multiomics-based therapeutic analyses
June 2025
Meniscal injury presents a formidable challenge and often leads to functional impairment and osteoarthritic progression. Meniscus tissue engineering (MTE) is a promising solution, as conventional strategies...
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Iterative selection of lipid nanoparticle vaccine adjuvants for rapid elicitation of tumoricidal CD8⁺ T cells
June 2025
A challenge for cancer vaccines is to elicit immune responses of sufficient magnitude to control malignant tumor growth and spread. In this study, we iteratively screened a panel of 22 lipid-phase vaccine...
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Microenvironment-responsive coating for vascular stents to regulate coagulation-inflammation interaction and promote vascular recovery
June 2025
Early coagulation-inflammation interaction and late in-stent restenosis undermine the efficacy of vascular stents after implantation. Targeting the interplay between inflammation and coagulation, and...
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Advanced biomaterials for targeting mature biofilms in periodontitis therapy
June 2025
Periodontitis is a chronic inflammatory disease primarily caused by bacteria, leading to inflamed and bleeding gums, periodontal pocket formation, and bone loss. Affecting 70%–90% of adults over 65,...
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Metastructure and strain-defect engineered Cu-doped TiOx coating to enhance antibacterial sonodynamic therapy
June 2025
Sonodynamic therapy (SDT) has attracted widespread attention in treatment of implant-associated infections, one of the key factors leading to implant failure. Nevertheless, constructing efficient ultrasound-triggered...
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Single-cell RNA sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtDNA/SPARC-STING signaling
June 2025
Intervertebral disc degeneration (IVDD) is a leading cause of discogenic low back pain, contributing significantly to global disability and economic burden. Current treatments provide only short-term...
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Innovative liquid embolic agents based on deep eutectic solvent: Rapid gelation in situ via solvent exchange with water for endovascular embolization
June 2025
Current liquid embolic agents face several challenges, including poor biocompatibility and vascular recanalization. Herein, we propose an innovative liquid embolic agent composed of a coenzyme-based...
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Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration
June 2025
Nucleus pulposus (NP) tissue engineering brings new hope in the repair of intervertebral disc degeneration (IVDD). IVDD is often accompanied by multiscale changes in the mechanical microenvironment,...
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MXenes as emerging materials to repair electroactive tissues and organs
June 2025
Nanomaterials with electroactive properties have taken a big leap for tissue repair and regeneration due to their unique physiochemical properties and biocompatibility. MXenes, an emerging class of...
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Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue
June 2025
Adipose tissue is highly vascularized, which is crucial for homeostasis and energy storage. Current efforts to engineer 3D vascularized adipose tissue in vitro typically involve co-culturing adipocytes...
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Topological cues of microparticles train stem cells for tissue repair via mechanotransduction
June 2025
Microspheres (MPs) and porous microspheres (PMPs) are the two most widely used microparticles in tissue engineering and stem cell therapy. However, how stem cells perceive the topological differences...
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