Mirror-image biology: perspectives and challenges
June 2026
Mirror-image biology is an emerging frontier in synthetic biology that uses chirally inverted biomolecules—D-proteins and L-nucleic acids—to construct orthogonal biological systems. Rapid advances in...
Optimization of cryopreservation of pathogenic microbial strains
December 2020
The preservation of pathogenic microbial strains is of great significance for basic research in microbiology and utilization of microbial resources. Appropriate preservation methods can maintain high...
Design, establishment and accreditation of biosafety Level 3 laboratory using the Egyptian experience for sustainable high-containment capacity in national biological defence structure
June 2026
BSL-3 laboratories are crucial for global health security because they provide a basis for the research and diagnostics of new and known infectious agents. Yet few such facilities have been established,...
Biosafety and biosecurity in the era of biotechnology: The Middle East region
December 2022
Biotechnology became a paradigm-shifting science among all subfields of biology. The benefits of biotechnology have reached many practical fields, whether human health, animal, and/or agricultural....
Regulating synthetic biology and advanced genetic interventions: biosecurity frameworks, gene therapy oversight, stem-cell manufacturing risks and future policy directions
June 2026
Gene editing (CRISPR-Cas9, base and prime editing), viral-vector therapies (adeno-associated virus [AAV] and lentiviral systems) and engineered stem cell platforms (induced pluripotent stem cells and...
Human genome editing after the “CRISPR babies”: The double-pacing problem and collaborative governance
March 2023
How to ensure the safe, effective, and ethical use of emerging biotechnologies, such as clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing, is a global challenge....
Status of biosafety and biosecurity performance after five years of implementation in a laboratory network in Tanzania: A need for targeted multisectoral capacity building
September 2026
Laboratory biosafety and biosecurity (BSBS) measures are vital for addressing global biological health security threats. Tanzania conducted the first Joint External Evaluation (JEE) of core capacities...
Biosafety and biosecurity
March 2019
With the profound changes in the international security situation, the progression of globalization, and the continuous advancement of biotechnology, the risks and challenges posed by major infectious...
Synthetic biology: Recent progress, biosafety and biosecurity concerns, and possible solutions
March 2019
Synthetic biology is a new interdisciplinary research area that uses engineering principles as guidelines for biological investigation. With research goals to modify existing biological systems or to...
Challenges and recent progress in the governance of biosecurity risks in the era of synthetic biology
June 2022
Considerable progress has been achieved in basic research and the biotechnological application of biological sciences in recent years. Synthetic biology integrates systems biology, engineering, computer...
Biosafety laboratory risk assessment
September 2019
Biosafety laboratory risk assessment is a dynamic and systematic work. The scope of the assessment involves evaluation of pathogenic microbial hazards, experimental activities, facilities and equipment,...
Ethical framework on risk governance of synthetic biology
June 2023
Synthetic biology is an emerging multidisciplinary field that aims to design and construct new biological systems not found in nature. Whereas synthetic biology may yield tremendous benefits, it may...
Integrated assessment of biosafety, biosecurity and cyber-biosecurity in clinical microbiology laboratories in Lubumbashi, Democratic Republic of the Congo
June 2026
Clinical microbiology laboratories in low-resource settings face increasing biological and digital risks, yet integrated evaluations of biosafety, biosecurity and cyberbiosecurity remain scarce in sub-Saharan...
Strategies to strengthen biosecurity regulation in the ASEAN region and the United States: Approaches and implications
June 2026
The rise of biological threats, such as new infectious diseases, including coronavirus disease (COVID-19), bioterrorism and unregulated biotechnology use, shows that it is critical for the Association...
A targeted vaccination strategy: Integrating vaccines into biosafety, biosecurity, and one health initiatives
March 2025
Vaccination has saved millions of lives and is regarded as one of modern medicine’s most important successes. Effective vaccination programs should be based on risk assessment that considers demographic...
Bioinformatic assessment of the potential for harm to humans via horizontal gene transfer from the planned release of genetically modified mosquito vectors
June 2026
•The potential for mosquito to human Horizontal Gene (HGT) Transfer was investigated.•This contributed to a risk assessment for the release of genetically modified mosquitoes.•Analysis of human and...
Designing a biosecurity educational website and assessing user engagement to enhance disease prevention and preparedness on beef cattle farms in the United States
September 2026
Infectious diseases pose a continuous threat to the health and sustainability of beef cattle farms. The implementation of effective biosecurity plans can reduce the spread of pathogens between and within...
Comparison of the binding energies of approved mpox drugs and phytochemicals through molecular docking, molecular dynamics simulation, and ADMET studies: An in silico approach
September 2023
•The binding affinity of Tecovirimat, Brincidofovir, Cidofovir against the mpox protein was examined in silico through molecular docking.•The binding affinity of such drugs/mAbs was compared with the...
Biosecurity education in school: A UK pilot study
September 2026
There are increasing calls for the introduction of biological security and general chemical, biological, radiological and nuclear (CBRN) security concepts to students in secondary schools and, more...
Raising biosafety awareness in public health laboratories in Egypt: lessons from a governorate partnering competition
September 2026
Strengthening biosafety culture in public health laboratories requires not only policies and technical training, but also participatory approaches that make biosafety priorities visible to both frontline...
Assessing decontamination practices at a medical microbiology research laboratory
December 2022
To our knowledge, this is the first study to conduct an objective assessment of the routine decontamination practices at a medical microbiology research laboratory (MRL) a year after a biosafety training...
The potential epidemic threat of Ebola virus and the development of a preventive vaccine
June 2023
Ebola virus (EBOV) is classified as a category A pathogen as it causes viral hemorrhagic fever, one of the most-deadly virus-related diseases. Since its discovery in 1976, EBOV has caused a number of...
Efficacy of commercial disinfectants Virkon®S and Microchem Plus against poliovirus
September 2025
The WHO Global Action Plan for Poliovirus Containment, 4th edition (GAPIV) describes the necessary conditions for the containment of poliovirus material in poliovirus-essential facilities (PEFs). PEF...
Laboratory information management system for biosafety laboratory: Safety and efficiency
June 2021
Laboratory information management system (LIMS) has been widely used to facilitate laboratory activities. However, the current LIMSs do not contain functions to improve the safety of laboratory work,...