Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing
December 2024
•A sprayable, efficient and convenient TACo nanozyme was designed via one-pot method.•TACo nanozyme exhibit pH-responsive and photothermal antibacterial properties.•TACo nanozyme can effectively relieve...
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Bone improvement in osteoporotic rabbits using CoCrMo implants
December 2024
•Metallic biomaterial helps to improve osteoporotic cortical bone.•The experience performed in animals reflected an increase in bone quality.•After 8 weeks, there was marked osteogenesis with both apposition...
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Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
December 2024
•Highly bioactive ECM microfibers serve as reinforce phase to strengthen CSH/CP@ECM-Deno mechanical property similar to cancellous bone.•Long-term release of denosumab regulates osteoclastogenesis by...
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Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects
December 2024
•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...
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Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
December 2024
•We have developed Bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase with high availability and bioactivity.•Our verification, using...
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A patch comprising human umbilical cord-derived hydrogel and mesenchymal stem cells promotes pressure ulcer wound healing
December 2024
•Patch of MSCs/dECM accelerated wound healing and enhanced re-epithelialization of PU in mice.•This effect can be attributed to the promotion of tissue re-epithelialization, collagen deposition, angiogenesis,...
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Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
December 2024
•Cochlear implant/MXene-based electricacoustic stimulation system is proposed and constructed.•Low-frequency electroacoustic stimulation promotes the growth and development of SGNs.•Low-frequency electroacoustic...
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Ginsenoside Rb1 improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip
September 2024
•The liver organoids-on-a-chip platform could recapitulate key features of human liver physiology.•Free fatty acid-induced liver organoids displayed typical pathological characteristics similar to those...
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Intelligent hydrogels for treating malignant melanoma
September 2024
•Potential options for treatment of malignant melanoma (MM) are being presented by emerging therapies like immunotherapy, photodynamic therapy and photothermal therapy due to their effective and secure...
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Advances in nano silver-based biomaterials and their biomedical applications
September 2024
•We report the various physical, chemical and biological methods for AgNP synthesis.•Antimicrobial effect of AgNPs allows effective use in wound healing and dentistry.•Unique optical properties of AgNPs...
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Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles
September 2024
•Green synthesized silver nanoparticles have shown promising results in wound healing, promoting faster healing and reducing infection risk.•These environmentally friendly nanoparticles offer a sustainable...
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Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression
September 2024
•3-Dimensional matrix fabricated from poly-l-lactide acid (PLLA) with collagen coating (PLLA/CC) displayed great biocompatibility and biodegradability properties.•Immobilization of conditioned medium...
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Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
September 2024
•The mechanism of osteoclastogenesis induced by rankl is very important.•Oleandin can inhibit RANKL-induced osteoclast formation and bone resorption in vitro.•Oleandrin effectively inhibited lipopolysaccharide-induced...
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Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres
September 2024
•The effect of strain on muscle tendon junction formation was investigated for the first time.•10 % cyclic strain induced the cell morphology changes and the gene expression and production of proteins...
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Cross-talk between biometal ions and immune cells for bone repair
September 2024
•The interplay between bioactive factors, bone-related cells, and immune system involved in bone repair continues to be of great scientific interest in the field of bone tissue regeneration.•In this...
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Microalgae-based drug delivery systems in biomedical applications
September 2024
•Applications of microalgae biomass as drug carrier.•Microalgae drug delivery systems based on simple preparation and surface modifying.•Applications of photosynthesis in microalgae as an oxygenator.•Applications...
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Instability-Driven 3D bioprinting for engineering composite bio-inks
September 2024
•Extrusion-based 3D printing techniques are advancing bioengineering with the innovative electric-assisted coil-write technology, enabling high-resolution and fast fabrication of intricate microstructures.•This...
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ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration
Available online 6 August 2024
•ORM1 was expressed in AIS bone tissues.•ORM1-positive AIS patient-derived osteoblasts, there was an increased expression of RANKL, decreased expression of OPG.•Osteoclasts overexpressing ORM1 promoted...
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Comparison of two hemostatic skin adhesive dressings, incorporating multi-metal bioactive glass
Available online 2 July 2024
•Multi-element bioactive glass nanoparticles (BG) were successfully synthesized.•Two skin adhesives, with GelMA back bone, based on adhesive molecules of DOPA and TA, integrating BG were developed.•Both...
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Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells
June 2024
•Sustained adenosine release achieved using S/O/W method in polymeric microparticles.•Controlled release of adenosine boosts mineralization & osteogenic differentiation.•Novel exploration of adenosine's...
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Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair
June 2024
•Developed a magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating material structure with magnetic stimulation for spinal cord regeneration.•Demonstrated that medium-intensity magnetic...
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The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus: Past, Present and Future Designs for an Emerging Surgical Solution
June 2024
•Nucleus pulposus replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs (IVDs).•Review of pathologies treated with this technology,...
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Microalgae-based drug delivery system for tumor microenvironment photo-modulating and synergistic chemo-photodynamic therapy of osteosarcoma
June 2024
•A natural photosynthetic microalgae (C. vulgaris) was used as drug carriers loaded with chemotherapeutic doxorubicin to develop a multifunctional therapeutic platform (CV@DOX) for tumor microenvironment...
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Flexible wearable sensors: An emerging platform for monitoring of bacterial infection in skin wounds
June 2024
•We introduced the distribution of bacteria in wound infections.•We summarized current methods for bacterial detection in wounds.•We discussed three kinds of flexible wearable sensors for bacterial...
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Emerging microfluidics for the modeling and treatment of arthritis
June 2024
•Arthritis is a general term for a variety of joint diseases, seriously affecting people's physical and mental health.•Microfluidic is a technology that allows the precise control of fluid in a micro-channel.•In...
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