Leveraging mitochondrial stress to improve healthy aging
January 2026
Aging is characterized by a progressive decline in physiological function, driven by intrinsic mechanisms (primary aging) and modifiable factors (secondary aging), ultimately leading to multimorbidity,...
Passing the baton
January 2026
Probiotics, gut microbiota and physical activity: A close relationship
January 2026
The topic of this review is the study of the gut microbiota (GM), and the use of probiotics, especially in humans, as a new frontier in the field of prevention and health in general. The beneficial...
Impact of wet and dry cupping therapy on endurance, perceived wellness, and exertion in recreational male runners
January 2026
Cupping therapy (CT), an ancient practice revived in modern sports medicine, offers potential benefits for athlete recovery and performance. Distinctions between wet CT (WCT) and dry CT (DCT) in sports...
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice
January 2026
Resistance exercise has been confirmed to be important for maintaining muscle mass and function. However, despite considerable experimental studies, the underlying mechanisms still requires further...
ATLAS study: Design, athletic performance, and sex-specific regression models for muscle strength in the Greek population
January 2026
ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes (CA). This article presents the study design,...
Molecular mechanisms of exercise-induced neuroprotection against Parkinson's disease
January 2026
Parkinson's disease (PD) is the second most common neurodegenerative disease that affects movement and cognitive function, resulting from the loss of the neurotransmitter dopamine due to the death of...
Proprioception deficits in chronic ankle instability associated with structural and functional alternations in cerebellar vermis
January 2026
Ankle proprioception deficits have been widely reported in patients with chronic ankle instability (CAI), but their central neuropathological mechanisms have not been fully discussed. So, we aimed to...
Does longer-muscle length resistance training cause greater longitudinal growth in humans? A systematic review
January 2026
This paper aimed to systematically review the literature regarding the effects of resistance training (RT) performed at longer-muscle length (LML) versus shorter-muscle length (SML) on proxy measurements...
Does transcranial direct current stimulation enhance the hypoalgesic effect of exercise?
January 2026
Exercise produces a decrease in pain sensitivity via an effect called exercise-induced hypoalgesia (EIH). Transcranial direct current stimulation (tDCS), acting on similar analgesic mechanisms as EIH,...
An exerkine-based prognostic index reveals immune heterogeneity and predicts outcomes across 33 cancers
January 2026
Exercise exerts tumor-suppressive effects across multiple malignancies, partly through exerkines—exercise-induced secreted factors with immunomodulatory and metabolic functions. However, the prognostic...
The characteristics of cerebral cortical oxygenation levels and functional connectivity under upper and lower limb exercise-induced fatigue
January 2026
This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy...
All-cause mortality, type 2 diabetes mellitus, and the adherence to the rest-activity rhythm in China in 1989–2015: a longitudinal cohort survey
Available online 22 January 2026
Substantial evidence exists regarding the health impacts of physical activity (PA) and sedentary behavior (SB). However, the influence of the dynamic interplay between PA and SB remains unclear. Concurrently,...
ATF5 is Required for the Normal Stress Response During Skeletal Muscle Denervation
Available online 14 January 2026
Denervation induces muscle atrophy, as well as a decrease in mitochondrial content and function. The cellular defence in response to this includes the Integrated Stress Response (ISR) and the Mitochondrial...
The validity and reliability of the Chinese version of the Physical Activity Neighborhood Environment Scale (PANES-CHN)
Available online 27 December 2025
Reliable and valid measures to assess environmental features that can support walking and bicycling in neighborhoods are useful for developing future interventions for physical activity (PA). This study...
Association between daily steps and calf muscle oxygen saturation in patients with symptomatic peripheral artery disease
Available online 27 December 2025
We determined whether patients with peripheral artery disease (PAD) who walked at least 7 000 steps/day had better microvascular function, assessed by calf muscle oxygen saturation (StO2), and more...
Differential association between localized thigh muscle activity and whole-body substrate use between overweight and normal-weight young men
Available online 26 December 2025
This study examined how localized thigh-muscle activation relates to whole-body substrate use in men with normal weight (NW) versus overweight/obesity (OW). Thirty-six participants ([21.4 ± 1.9] years),...
The relationship between circulating osteocalcin and muscle mass measurements in humans: A systematic review and meta-analysis
Available online 13 December 2025
Osteocalcin (OC) and the undercarboxylated form (ucOC) are bone-derived peptide hormones produced by osteoblasts that are involved in systemic metabolism and skeletal muscle mass regulation. Human studies...
The anterior cruciate ligament (ACL) injury ‘Epidemic’: A perfect storm for Post-Traumatic Osteoarthritis
Available online 6 December 2025
Anterior cruciate ligament (ACL) injuries are increasingly common, particularly among women and adolescents participating in high-intensity, multidirectional sports. Despite being a small ligament,...
Physiological basis for recommending changes to the physical activity guidelines
November 2025
The rapid drop in mortality risk as people become more active has been known for some time. While the public health message is clear (i.e., that any physical activity [PA] is better than no PA), no...
Physical activity during COVID-19 pandemic: A 5-year retrospect
November 2025
The purpose of this article is to provide a follow-up review of the impact of the SARS-CoV-2 Disease or Coronavirus Disease 2019 (COVID-19) pandemic on human health and the role of physical activity...
The functional state of athletes who have undergone coronavirus infection (COVID-19)
November 2025
This study aimed to investigate the energy supply of athletes, who had a mild form of coronavirus infection (COVID-19) under cycling ergometric load (CEL) to substantiate the timing of recovery, as...
People with hip osteoarthritis have reduced quadriceps voluntary activation and altered motor cortex function
November 2025
Compare quadriceps voluntary activation, corticospinal and intracortical excitability between people with and without hip osteoarthritis (OA). Exploratory objectives include quantifying the association...
Effects of 8-weeks Surf Skateboard training on physical fitness in young people
November 2025
Surf skateboards have grown in popularity among young people in recent years. However, no research studies have analyzed the effect of surf skateboarding on physical fitness....
Within-subject time series angular velocity differences between in-game high and low velocity fastballs in college baseball pitchers
November 2025
The purpose of the current study is to investigate the within-pitcher differences in time series angular velocities of the pelvis, trunk, shoulder, and elbow for high and low velocity fastballs in college...