Recent advances in the development and clinical application of miRNAs in infectious diseases
February 2025
In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important regulators of gene expression,...
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Emerging roles of non-coding RNAs in modulating the PI3K/Akt pathway in cancer
February 2025
Cancer progression results from the dysregulation of molecular pathways, each with unique features that can either promote or inhibit tumor growth. The complexity of carcinogenesis makes it challenging...
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Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response
February 2025
The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression. Circular RNAs (circRNAs),...
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The relationship between microRNAs and COVID-19 complications
February 2025
Over the past three years, since the onset of COVID-19, several scientific studies have concentrated on understanding susceptibility to the virus, the progression of the illness, and possible long-term...
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Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics
December 2024
Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with...
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Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system
February 2025
Recently, the various regulative functions of long non-coding RNAs (LncRNAs) have been well determined. Recently, the vital role of LncRNAs as gene regulators has been identified in the immune system,...
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RNA and liquid-liquid phase separation
June 2021
Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining...
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MiR-6721-5p as a natural regulator of Meta-VCL is upregulated in the serum of patients with coronary artery disease
February 2025
Coronary artery disease (CAD), the leading cause of mortality globally, arises from atherosclerotic blockage of the coronary arteries. Meta-vinculin (meta-VCL), a large spliced isoform of VCL, co-localizes...
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MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions
March 2020
Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration...
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Research progress on the tsRNA biogenesis, function, and application in lung cancer
February 2025
In recent years, there has been a mounting occurrence of lung cancer, which stands as one of the most prevalent malignancies globally. This rise in incidence poses a significant hazard to human health,...
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The roles of long non-coding RNAs in Alzheimer's disease diagnosis, treatment, and their involvement in Alzheimer's disease immune responses
September 2024
Alzheimer's disease (AD) is the most frequent type of dementia, presenting a substantial danger to the health and well-being of the aged population. It has arisen as a significant public health problem...
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Innovative approaches to metabolic dysfunction-associated steatohepatitis diagnosis and stratification
February 2025
The global rise in Metabolic dysfunction-associated steatotic liver disease (MASLD)/Metabolic dysfunction-associated steatohepatitis (MASH) highlights the urgent necessity for noninvasive biomarkers...
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LncRNA NEAT1 and miRNA 101 as potential diagnostic biomarkers in patients with alopecia areata
February 2025
Alopecia areata (AA) commonly displays as non-scarring, irregular hair loss. Experimental and clinical research have specifically implicated autoimmunity and genetics in the disruption of anagen hair...
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Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis
December 2024
Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury....
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The role of long non-coding RNA NORAD in digestive system tumors
February 2025
In recent years, it has been discovered that the expression of long non-coding RNAs is highly deregulated in several types of cancer and contributes to its progression and development. Recently, it...
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Long non-coding RNAs: Mechanism of action and functional utility
October 2016
Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...
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The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution
April 2025
Eusociality, characterized by reproductive division of labor, cooperative brood care, and multi-generational cohabitation, represents a pinnacle of complex social evolution, most notably manifested...
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NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?
December 2018
Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...
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miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma
March 2024
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory...
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MiRNA expression affects survival in patients with obstructive sleep apnea and metastatic colorectal cancer
February 2025
The relationship between obstructive sleep apnea (OSA) and cancer has been recognized for some time now. However, little is known about the mechanisms by which sleep apnea promotes tumorigenesis and...
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Circular SERPINA3 and its target microRNA-944 as potential molecular biomarkers in hepatitis C virus-induced hepatocellular carcinoma in Egyptian population
September 2023
The most prevalent cancer in Egypt is hepatocellular carcinoma (HCC) mainly due to the infection with the hepatitis C virus. So it is critical to find sensitive biomarkers for early diagnosis of HCC...
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Small non-coding RNAs as regulators of structural evolution and carcinogenesis
June 2017
Small non-coding RNAs (sncRNAs) are part of non-coding oligonucleotide regulators with wide physiologic and morphologic functions. They control genetic programing of cells, and may modulate processes...
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Circular RNAs: New layer of complexity evading breast cancer heterogeneity
March 2023
Advances in high-throughput sequencing techniques and bioinformatic analysis have refuted the “junk” RNA hypothesis that was claimed against non-coding RNAs (ncRNAs). Circular RNAs (circRNAs); a class...
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The full recovery of mice (Mus Musculus C57BL/6 strain) from virus–induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs
June 2019
Virus-induced cellular genetic modifications result in the development of many human cancers....
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The role of microRNAs in atopic dermatitis
December 2024
Atopic dermatitis (AD), known as eczema, is a chronic inflammatory skin condition affecting millions worldwide. This abstract provides an overview of the clinical features and underlying pathogenesis...
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