Special Issue- Neurodegeneration: The Emerging Non-coding Connections

Non-coding RNAs play important functions in cellular metabolism and have been identified as important molecules in maintaining the correct function of the Central Nervous System (CNS). Misregulation of lncRNAs, miRNAs and circRNAs in the CNS have all been implicated in neurodegeneration, neuro-developmental, -psychiatric and -immunological disorders. However, to date little is known about the precise regulatory mechanisms and functions that lncRNAs use to regulate gene expression in the CNS, both at the transcriptional and post-transcriptional level. Like-wise, the brain expresses one of largest numbers of miRNAs and circRNAs of all mammalian organs, yet the expression level of many individual miRNAs and their mRNA targets remain elusive. Given that non-coding RNAs exert such key roles in the CNS, they could provide ideal therapeutic targets to treat neurological disorders.

For these reasons, in this Non-coding RNA Research special issue entitled “Neurodegeneration: The Emerging Non-coding Connections”, we have aimed to assemble a collection of key reviews that provide the latest insight into what we know about lncRNAs, miRNAs and circRNAs in the CNS and their regulation and biological functions in health and disease.

The main topics of consideration for this special issue include, but are not limited to:

• Non-coding RNAs as therapeutic targets in neurodegeneration,
• Non-coding RNAs in memory and learning,
• New technology advances
• Non-coding RNA-based biomarker and prognostic studies
• Bioinformatics of non-coding RNA

Yours sincerely,
Special Issue Guest Editors

Emanuele Buratti
Molecular Pathology Group
International Centre for Genetic Engineering and Biotechnology (ICGEB)
Trieste, Italy
Email: buratti@icgeb.org

Dipen Rajgor
Department of Biochemistry
University of Bristol
Bristol, UK
Email: dipen.rajgor@bristol.ac.uk

Paper submission due:
30 September 2018