Nitrate and body homeostasis
March 2024
Homeostasis is essential for the maintenance of health, and how it is maintained is the focus of attention in homeostatic medicine. As a natural dietary nutrient, nitrate is critical in regulating homeostasis....
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Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant
June 2024
With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked...
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Intracranial neurophysiological correlates of rumination: A cross-sectional observational study
September 2024
Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders, albeit its neurophysiological basis remains elusive. Existing neuroimaging studies...
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Big connectome imaging data in psychiatric disorders
September 2024
Psychiatric disorders are a pressing public health challenge, posing a significant threat to the well-being of millions of people worldwide. Their elusive etiology, rooted in the complex interplay of...
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Relationship between tight junctions of the BBB and astrocyte connective function in epilepsy: Albumin and astrocyte activation
September 2024
The blood-brain barrier (BBB) is a barrier system separating the central nervous system from blood circulation. Connections between cells within the BBB involve specialized endothelial tight junction...
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Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery
March 2024
Degrader technologies provide unprecedented strategies to tackle diseases caused by pathogenic proteins that are difficult to target by the traditional inhibitor approach. One pioneering technology,...
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Translating “AI for omics” into precision therapy
September 2024
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Health research in the era of artificial intelligence: Advances in gene-editing study
June 2024
In recent years, gene editing technology, represented by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) has made a revolutionary breakthrough....
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Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
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Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study
September 2024
Cachexia is a global burden that is caused by chronic diseases such as cancer. It is characterized by inflammation and progressive loss of muscle and adipose tissue, aggravating the patient’s health....
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Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
March 2024
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate...
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Artificial intelligence in coronary computed tomography angiography
March 2024
The rapid development of artificial intelligence (AI) technologies, like machine learning, deep learning, and other algorithms applied to the intelligent diagnostic and decision making, image interpretation,...
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Associations of long-term exposure to fine particulate matter and its constituents with gynecologic cancer incidence: A prospective cohort study from Beijing
December 2024
There is limited evidence of the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 µm (fine particulate matter, PM2.5) and gynecologic cancer incidence, particularly...
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Tumor deposits in colorectal and gastric cancers
June 2024
Tumor deposits (TDs), initially recognized in colorectal cancer (CRC), have been identified in various other cancer types, including gastric cancer (GC), rendering them a widely studied adverse prognostic...
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Progresses in genetic testing in congenital heart disease
June 2024
Congenital heart disease (CHD) encompasses a range of structural malformations affecting the heart and major blood vessels present at birth. The genetic underpinnings of CHD have long been recognized...
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Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder
March 2024
Early-onset schizophrenia (EOS) and autism spectrum disorder (ASD) are two mental disorders with abnormal neurodevelopment and overlapping clinical symptoms. However, few prospective multi-center imaging...
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Osteoblast-derived extracellular vesicles exert bone formation effects by WIF1-mediated regulation of mitophagy
June 2024
Osteoporosis arises mainly from an imbalance in bone remodeling, characterized by the impaired ability of osteoblasts (OBs) to form new bone. A significant challenge remains in identifying and validating...
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Structural and biochemical basis for the pathogenic mutations of methylmalonate semialdehyde dehydrogenase ALDH6A1
December 2024
Methylmalonate semialdehyde dehydrogenase (ALDH6A1), encoded by the ALDH6A1 gene, is essential for the metabolic degradation of valine and thymine. Genetic alterations in ALDH6A1 lead to methylmalonate...
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Targeting RIP3 inhibits osteoarthritis development by restoring anabolic-catabolic balance in the bone-cartilage unit
June 2024
Osteoarthritis (OA) is a debilitating joint disorder characterized by progressive cartilage degeneration. During OA, subchondral bone undergoes microstructural and molecular changes that precede cartilage...
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Boron neutron capture therapy of cancer: Recent progress
September 2024
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