The versatility of apigenin: Especially as a chemopreventive agent for cancer
December 2024
Apigenin, a naturally occurring flavonoid found in fruits and vegetables, has received substantial attention due to its various pharmacological effects, particularly in cancer therapy. This review delves...
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Secondary metabolites from the cold-seep-derived fungus Penicillium sp. SCSIO 41425 and their free radical scavenging activity
December 2024
To study the chemical compositions from Penicillium sp. SCSIO 41425 and explore their DPPH radical scavenging activity....
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Research on the role and mechanism of Aloe vera (L.) Burm.f. in the treatment of burn: Based on network pharmacology analysis and experimental verification
December 2024
Burn is a suddenly occurring injury. The healing process of burn is complex. Aloe vera (L.) Burm.f. (Av) is widely used as Chinese folk medicine for the treatment of burn. While effective pharmacological...
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Human Epididymis Protein 4 (HE4) as a promising biomarker and therapy target in fibrotic diseases: A review
December 2024
The treatment of fibrosis faces a significant challenge due to the lack of effective therapies that can reverse established fibrosis. Early detection is vital for intervention, yet distinguishing fibrosis...
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Network pharmacology-based study on the mechanism of Yiwei Decoction in chronic atrophic gastritis and experimental assessment
December 2024
Yiwei Decoction (YWD) is an ancient TCM formula with historical use in treating chronic atrophic gastritis (CAG). However, its pharmacodynamic mechanisms remain poorly understood. This study aims to...
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Study on the application of Aloe vera in cosmetology and clinical treatment of skin diseases
December 2024
The medicinal value of Aloe vera (AV) has been continuously explored and utilized in recent years, becoming a research hotspot. Some basic studies have found that AV had cosmetic effects such as whitening,...
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Anticancer flavonoids producing endophytic fungi: A review
December 2024
Plants living in different environments inhabit endophytic microbes. The relationship between plants and endophytic microbes may be symbiotic or parasitic. Transmission of endophytes varies when they...
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Pedalitin could regulate lipid metabolism and attenuate inflammatory factors in a non-alcoholic fatty liver disease cell model
December 2024
Nonalcoholic fatty liver disease (NAFLD) is an escalating global health issue, leading to liver fat accumulation, inflammation, fibrosis, and potential liver failure. In our preliminary network pharmacological...
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Preparation of purine functionalized biochar and analysis of nephrotoxic substances in traditional Chinese medicine
September 2024
In recent years, a growing lack of comprehension regarding the safety of traditional Chinese medicines (TCMs) has led to an escalating incidence of drug-induced organ damage, particularly kidney damage...
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Holistic integrative medicine declaration
September 2024
Holistic integrative medicine, abbreviated as HIM, has been officially proposed since 2012. Its theoretical system has been continuously improved, and its practical methods have become increasingly...
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Ferroptosis: A prospective therapeutic target for radiotherapy- and chemotherapy-induced gastrointestinal inflammation
September 2024
Ferroptosis is a unique mode of cell death driven by iron-dependent lipid peroxidation, and the process is regulated by a variety of cellular metabolic pathways, including redox homeostasis, iron processing,...
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Research progress in application of alginate gel as tumor drug delivery carrier, for tumor localization and 3D tumor cell model
September 2024
As one of the hot materials in biomedical research, alginate gel shows great potential in tumor therapy with its unique physical and chemical properties. In order to better meet the complex needs of...
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Exercise therapy: Anti-tumor and improving chemotherapy efficacy
September 2024
The extant research evidence indicates that sensible exercise has a beneficial impact on the prevention and treatment of cancer. This paper presents a comprehensive literature review of the field of...
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The research advance on the theory of Chinese medicine-exterior-interior correlation between the Lung and Large Intestine in the treatment of chronic cough
September 2024
Coughing as the main symptom of a chronic cough is a persistent respiratory disease that poses a substantial challenge to Western medicine and traditional Chinese medicine (TCM). The Large Intestine...
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Zebrafish as a rapid model system for early cardiotoxicity assessment of drugs
September 2024
There are some problems in the evaluation of drug cardiotoxicity in zebrafish, such as unsystematic indicators and weak sensitivity. This study aims to explore the advantages and disadvantages of various...
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Potential anti-colon cancer agents: Molecular modelling, docking, pharmacokinetics studies and molecular dynamic simulations
September 2024
The objective of this investigation is to create a trustworthy Quantitative Structure-Activity Relationship (QSAR) model that generates little to no side effects and is low-cost for treating colon cancer...
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Safety and risk control study of antibody preparation based on CiteSpace
September 2024
To analyze the hotspots, patterns, and distribution of research on the safety and risk of antibody preparations in the past 20 years. It also seeks to summarize the current status and trends of research...
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Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
September 2024
Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties...
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Cyclotides prediction in Leptopetalum biflorum based on de novo transcriptome assembly and annotation
June 2024
There is a scarcity of transcriptome sequencing data available for the Leptopetalum biflorum, and numerous cyclotides remain undiscovered. It is urgent to establish a workflow based on de novo transcriptome...
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Construction a six-gene prognostic model for hepatocellular carcinoma based on WGCNA co-expression network
June 2024
Currently, the incidence of hepatocellular carcinoma remains high, and the prognosis of patients is poor. Prognostic biomarkers are still worth exploring....
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Deciphering the anti-senescence immune paradigm: Kidney yin-yang equilibrium in traditional Chinese medicine
June 2024
In traditional Chinese medicine (TCM), the kidney is considered the "innate foundation", and the abundance or diminution of its essence directly affects the growth, development, physical form, and physiological...
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Liujunzi decoction attenuates cisplatin-induced anorexia in rats via inhibiting PERK/eIF2α/ATF4/CHOP pathway and GDF15/GFRAL expression
June 2024
Liujunzi Decoction (LJZD), also called Rikkunshito, is a traditional formula that has proven effective in clinical treatment against chemotherapy-induced anorexia (CIA). Previous study indicated the...
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Progress, challenges, and prospects of small extracellular vesicles isolation and characterization
June 2024
Exosomes are nanoparticles that can be secreted by almost all cells into the extracellular space and carry active substances such as nucleic acids, lipids, and proteins and can participate in intercellular...
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The functions and applications of organoids in rheumatic immune diseases
June 2024
Rheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the...
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Evolution of Salvia key enzyme genes based on metabolomic and transcriptomic insights into mitochondrial quality control
June 2024
The purpose of this study was to explore the relationship between the evolution of key Salvia enzyme genes and metabolite biological activity on mitochondrial quality control. Metabolomics and transcriptomics...
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