Vitamins strategies for psoriasis: An update on current scientific evidence
December 2023
Psoriasis is an aggressive chronic skin disorder that requires various therapies such as topical, oral, and occasionally, subcutaneous, or intravenous. In contrast, vitamins have more significant evidence...
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Deciphering the anti-senescence immune paradigm: Kidney yin-yang equilibrium in traditional Chinese medicine
June 2024
In traditional Chinese medicine (TCM), the kidney is considered the "innate foundation", and the abundance or diminution of its essence directly affects the growth, development, physical form, and physiological...
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Exploring the therapeutic effects of Zingiberis Rhizoma Preparatum (Pao-Jiang) against DSS-induced ulcerative colitis in mice by metabolomics-guided analysis
December 2023
Zingiberis Rhizoma Recens (Sheng-Jiang) is a kind of edible and medicinal plant resource in China. Both Zingiberis Rhizoma Recens and its dried form, Zingiberis Rhizome (Gan-Jiang), have been widely...
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The functions and applications of organoids in rheumatic immune diseases
June 2024
Rheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the...
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Progress, challenges, and prospects of small extracellular vesicles isolation and characterization
June 2024
Exosomes are nanoparticles that can be secreted by almost all cells into the extracellular space and carry active substances such as nucleic acids, lipids, and proteins and can participate in intercellular...
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Qingjie Fuzheng granules treat ulcerative colitis by regulating Th17/Treg balance
June 2024
To investigate the anti-inflammatory properties of Qingjie Fuzheng granules (QFG) in vivo using a dextran sulfate sodium (DSS)–induced ulcerative colitis (UC) model and elucidate the mechanism of which...
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Cyclotides prediction in Leptopetalum biflorum based on de novo transcriptome assembly and annotation
June 2024
There is a scarcity of transcriptome sequencing data available for the Leptopetalum biflorum, and numerous cyclotides remain undiscovered. It is urgent to establish a workflow based on de novo transcriptome...
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Evolution of Salvia key enzyme genes based on metabolomic and transcriptomic insights into mitochondrial quality control
June 2024
The purpose of this study was to explore the relationship between the evolution of key Salvia enzyme genes and metabolite biological activity on mitochondrial quality control. Metabolomics and transcriptomics...
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Construction a six-gene prognostic model for hepatocellular carcinoma based on WGCNA co-expression network
June 2024
Currently, the incidence of hepatocellular carcinoma remains high, and the prognosis of patients is poor. Prognostic biomarkers are still worth exploring....
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Methodological project (SMART-PT) for transparency and methodological characteristics of randomized controlled trials of phytotherapy interventions
December 2023
Randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy and safety of medical interventions. Phytotherapy, which plays a critical role in the prevention and treatment of...
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Synthesis, cytotoxicity study of novel bisacridine derivatives and their interaction with c-myc promoter G-quadruplex/i-motif
December 2023
To synthesize novel bisacridine derivatives A1-A4 and study cytotoxicity and their interaction with c-myc G-quadruplex/i-motif DNA....
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Liujunzi decoction attenuates cisplatin-induced anorexia in rats via inhibiting PERK/eIF2α/ATF4/CHOP pathway and GDF15/GFRAL expression
June 2024
Liujunzi Decoction (LJZD), also called Rikkunshito, is a traditional formula that has proven effective in clinical treatment against chemotherapy-induced anorexia (CIA). Previous study indicated the...
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Chloroplast genome of Thesium chinense: The insight into phylogeny of Santalaceae
December 2023
Thesium chinense is an important and commonly used traditional Chinese medicine. The aim of this study is to obtain more bioinformatics from Thesium chinense and to conduct a more comprehensive and...
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Combining single-cell RNA sequencing data and network pharmacology to explore the mechanism of action of Dayuan Yin in the treatment of acute lung injury
December 2023
This study aimed to analyze the usefulness of combined single-cell RNA sequencing data and network pharmacology in understanding the molecular regulation mechanism of Dayuan Yin (DYY) in acute lung...
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Review of compounds and activities from mangrove Sonneratia genus and their endophytes
November 2023
Sonneratia is an important mangrove plant, and its fruit has been used as traditional medicine and food in southeast China. With recent research focusing on its compounds and activities, an increasing...
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Genomics-based tools for drug discovery and development: From network maps to efficacy prediction
November 2023
Computing technology plays a crucial role in the field of drug discovery and development. With the rapid development of genomics and the improvement of databases, the application of genomics-based tools...
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Truxillic and truxinic acid derivatives: configuration, source, and bioactivities of natural cyclobutane dimers
September 2020
Natural truxillic and truxinic acid derivatives are interesting cyclobutane dimers, with different stereo conformations formed by the orientation of groups on the cyclobutane. These derivatives are...
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Preparation of purine functionalized biochar and analysis of nephrotoxic substances in traditional Chinese medicine
September 2024
In recent years, a growing lack of comprehension regarding the safety of traditional Chinese medicines (TCMs) has led to an escalating incidence of drug-induced organ damage, particularly kidney damage...
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Exercise therapy: Anti-tumor and improving chemotherapy efficacy
September 2024
The extant research evidence indicates that sensible exercise has a beneficial impact on the prevention and treatment of cancer. This paper presents a comprehensive literature review of the field of...
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Peptide drugs application in metabolic diseases and discovery strategies
March 2022
Peptides (or polypeptides) are generally defined as those molecules compounded with less than 100 amino acids linked by peptide bonds, and the relative molecular weight is less than 10 000 Da usually....
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Ferroptosis: A prospective therapeutic target for radiotherapy- and chemotherapy-induced gastrointestinal inflammation
September 2024
Ferroptosis is a unique mode of cell death driven by iron-dependent lipid peroxidation, and the process is regulated by a variety of cellular metabolic pathways, including redox homeostasis, iron processing,...
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Potential anti-colon cancer agents: Molecular modelling, docking, pharmacokinetics studies and molecular dynamic simulations
September 2024
The objective of this investigation is to create a trustworthy Quantitative Structure-Activity Relationship (QSAR) model that generates little to no side effects and is low-cost for treating colon cancer...
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Pharmacognostic studies on three species of Spermacoce
March 2024
To provide a scientific basis for identification of Spermacoce species, including Spermacoce remota Lamarck, Spermacoce exilis (L. O. Williams) C. D. Adams, and Spermacoce alata Aubl., the current study...
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Optimisation study on the flavonoid extraction process from Abrus precatorius leaves and the comparison of total flavonoid content by HPLC and UV
October 2023
Abrus precatorius is a leguminous plant with high medicinal value. Its leaves are rich in flavonoids. There only are limited reports on the extraction process and quality assessment of total flavonoids...
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