Vitamins strategies for psoriasis: An update on current scientific evidence
December 2023
Psoriasis is an aggressive chronic skin disorder that requires various therapies such as topical, oral, and occasionally, subcutaneous, or intravenous. In contrast, vitamins have more significant evidence...
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Zebrafish as a rapid model system for early cardiotoxicity assessment of drugs
September 2024
There are some problems in the evaluation of drug cardiotoxicity in zebrafish, such as unsystematic indicators and weak sensitivity. This study aims to explore the advantages and disadvantages of various...
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Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
September 2024
Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties...
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Ferroptosis: A prospective therapeutic target for radiotherapy- and chemotherapy-induced gastrointestinal inflammation
September 2024
Ferroptosis is a unique mode of cell death driven by iron-dependent lipid peroxidation, and the process is regulated by a variety of cellular metabolic pathways, including redox homeostasis, iron processing,...
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The research advance on the theory of Chinese medicine-exterior-interior correlation between the Lung and Large Intestine in the treatment of chronic cough
September 2024
Coughing as the main symptom of a chronic cough is a persistent respiratory disease that poses a substantial challenge to Western medicine and traditional Chinese medicine (TCM). The Large Intestine...
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Study on the application of Aloe vera in cosmetology and clinical treatment of skin diseases
December 2024
The medicinal value of Aloe vera (AV) has been continuously explored and utilized in recent years, becoming a research hotspot. Some basic studies have found that AV had cosmetic effects such as whitening,...
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Deciphering the anti-senescence immune paradigm: Kidney yin-yang equilibrium in traditional Chinese medicine
June 2024
In traditional Chinese medicine (TCM), the kidney is considered the "innate foundation", and the abundance or diminution of its essence directly affects the growth, development, physical form, and physiological...
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Preparation of purine functionalized biochar and analysis of nephrotoxic substances in traditional Chinese medicine
September 2024
In recent years, a growing lack of comprehension regarding the safety of traditional Chinese medicines (TCMs) has led to an escalating incidence of drug-induced organ damage, particularly kidney damage...
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Genomics-based tools for drug discovery and development: From network maps to efficacy prediction
November 2023
Computing technology plays a crucial role in the field of drug discovery and development. With the rapid development of genomics and the improvement of databases, the application of genomics-based tools...
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The versatility of apigenin: Especially as a chemopreventive agent for cancer
December 2024
Apigenin, a naturally occurring flavonoid found in fruits and vegetables, has received substantial attention due to its various pharmacological effects, particularly in cancer therapy. This review delves...
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Liujunzi decoction attenuates cisplatin-induced anorexia in rats via inhibiting PERK/eIF2α/ATF4/CHOP pathway and GDF15/GFRAL expression
June 2024
Liujunzi Decoction (LJZD), also called Rikkunshito, is a traditional formula that has proven effective in clinical treatment against chemotherapy-induced anorexia (CIA). Previous study indicated the...
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Research on the role and mechanism of Aloe vera (L.) Burm.f. in the treatment of burn: Based on network pharmacology analysis and experimental verification
December 2024
Burn is a suddenly occurring injury. The healing process of burn is complex. Aloe vera (L.) Burm.f. (Av) is widely used as Chinese folk medicine for the treatment of burn. While effective pharmacological...
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Qingjie Fuzheng granules treat ulcerative colitis by regulating Th17/Treg balance
June 2024
To investigate the anti-inflammatory properties of Qingjie Fuzheng granules (QFG) in vivo using a dextran sulfate sodium (DSS)–induced ulcerative colitis (UC) model and elucidate the mechanism of which...
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Exploring the therapeutic effects of Zingiberis Rhizoma Preparatum (Pao-Jiang) against DSS-induced ulcerative colitis in mice by metabolomics-guided analysis
December 2023
Zingiberis Rhizoma Recens (Sheng-Jiang) is a kind of edible and medicinal plant resource in China. Both Zingiberis Rhizoma Recens and its dried form, Zingiberis Rhizome (Gan-Jiang), have been widely...
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Peptide drugs application in metabolic diseases and discovery strategies
March 2022
Peptides (or polypeptides) are generally defined as those molecules compounded with less than 100 amino acids linked by peptide bonds, and the relative molecular weight is less than 10 000 Da usually....
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Truxillic and truxinic acid derivatives: configuration, source, and bioactivities of natural cyclobutane dimers
September 2020
Natural truxillic and truxinic acid derivatives are interesting cyclobutane dimers, with different stereo conformations formed by the orientation of groups on the cyclobutane. These derivatives are...
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Review of compounds and activities from mangrove Sonneratia genus and their endophytes
November 2023
Sonneratia is an important mangrove plant, and its fruit has been used as traditional medicine and food in southeast China. With recent research focusing on its compounds and activities, an increasing...
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The functions and applications of organoids in rheumatic immune diseases
June 2024
Rheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the...
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Secondary metabolites from the cold-seep-derived fungus Penicillium sp. SCSIO 41425 and their free radical scavenging activity
December 2024
To study the chemical compositions from Penicillium sp. SCSIO 41425 and explore their DPPH radical scavenging activity....
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Visual analysis of drug research and development based on artificial intelligence
December 2024
The iteration of artificial intelligence (AI) technology provides new opportunities for drug research and experimental development. In recent years, AI-based drug research has continuously made new...
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Pedalitin could regulate lipid metabolism and attenuate inflammatory factors in a non-alcoholic fatty liver disease cell model
December 2024
Nonalcoholic fatty liver disease (NAFLD) is an escalating global health issue, leading to liver fat accumulation, inflammation, fibrosis, and potential liver failure. In our preliminary network pharmacological...
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Anticancer flavonoids producing endophytic fungi: A review
December 2024
Plants living in different environments inhabit endophytic microbes. The relationship between plants and endophytic microbes may be symbiotic or parasitic. Transmission of endophytes varies when they...
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Pharmacognostic studies on three species of Spermacoce
March 2024
To provide a scientific basis for identification of Spermacoce species, including Spermacoce remota Lamarck, Spermacoce exilis (L. O. Williams) C. D. Adams, and Spermacoce alata Aubl., the current study...
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Holistic Integrative Pharmacy and disease control
December 2020
As disease models are continually advancing, we could realize the “integration of knowledge and action” in pharmacy to prevent and treat diseases more effectively. This can only be done by advocating...
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Human Epididymis Protein 4 (HE4) as a promising biomarker and therapy target in fibrotic diseases: A review
December 2024
The treatment of fibrosis faces a significant challenge due to the lack of effective therapies that can reverse established fibrosis. Early detection is vital for intervention, yet distinguishing fibrosis...
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