Progress on anti-aging effects and mechanisms of the new ginsenoside Compound K

Skin aging, an inevitable aspect of the aging process, has gained notable attention in research, particularly in the context of finding effective anti-aging ingredients. Ginseng, known as the "king of herbs," has long been valued for its health benefits and contains various bioactive compounds, with ginsenosides being the most prominent.

In particular, ginsenosides such as Rg2 and Compound K (CK), have demonstrated promising anti-aging properties. They prevent collagen degradation, inhibit matrix metalloproteinase-1 (MMP-1) expression, and activat multiple antioxidant and longevity-related signaling pathways including FOXO/DAF-16, NRF2/SKN-1 and SIRT1/SIR 2.1.

In a recent review published in the Journal of Dermatologic Science and Cosmetic Technology, it was revealed that much focused has been placed on CK, largely due to its higher bioavailability and solubility compared to its parent compounds. Notably, CK exhibits a variety of beneficial effects, including the ability to enhance skin barrier function, prevent photoaging, regulate autophagy and protect against mitochondrial dysfunction. These effects occur through the inhibition of MMP-1 expression, upregulation of collagen synthesis, and activation of antioxidant pathways.

The review reported that CK improves skin hydration and reduces transepidermal water loss (TEWL) in the epidermis by promoting tight junctions between keratinocytes. In the dermis, it protects collagen and elastin fibers by inhibiting MMP activity and stimulating procollagen production. CK also stimulates hyaluronic acid synthesis, a key component of the extracellular matrix, and regulates mitochondrial function by enhancing ATP production and reducing mitochondrial ROS accumulation. Moreover, CK promotes autophagy, maintaining cellular homeostasis and delaying aging processes.

Additionally, CK has potent anti-inflammatory properties, balancing the polarization of macrophages towards an anti-inflammatory phenotype. It reduces the secretion of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, while increasing anti-inflammatory factors like IL-10. The ability of CK to penetrate the skin and act in deeper layers further amplifies its potential in skincare formulations.

Contact author:

Shuibin Cen, Guangzhou Guangya Xinhanfang Cosmetics Technology Co., LTD, Guangzhou 510630, China

School of Chemical Engineering and Technology, Guangdong Industry Polytechnic University Guangzhou, Guangdong 510300, Simen_cen@126.com

Conflict of interest:

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

See the article:

https://www.sciencedirect.com/science/article/pii/S2950306X25000056#keys0005