Green polyurethanes from bio-based building blocks: recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers thanks to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable...
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Advanced green synthesis: Solvent-free and catalyst-free reaction
Available online 9 November 2024
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Ate complexes in organic synthesis: From ate reagents to ate catalysts
August 2024
The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years, owing much to the evolution of ate complexes from mere reagents to versatile...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
Available online 3 October 2024
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
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Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies
November 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on carbonylation reactions have been published, summaries on cheap metal-catalyzed...
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Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
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Photoredox decarboxylative acylation of carboxylic acid by 4-acyl-1,2,3-triazoliums
Available online 18 October 2024
Recent advancements in NHC-based radical coupling reactions have introduced NHC-derived ketyl radicals as innovative persistent radicals. However, current work involves NHC-based radical-radical coupling...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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Recent advances in photocatalytic C-H amination to nitrogenous structures
Available online 5 October 2024
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity, surpassing non-nitrogen architectures. Given the vast array of nitrogen-containing compounds...
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Synthesis of dydrogesterone by aromatization-dearomatization strategy
Available online 15 December 2023
Dydrogesterone as an agonist of the progesterone receptor is an important and selective synthetic progesterone used for the treatment of a variety of conditions associated with progesterone deficiency...
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The roles of computer-aided drug synthesis in drug development
February 2022
With the improvements in computer computing ability, data accumulation and rapid algorithm development, the integration of artificial intelligence (AI) and drug synthesis has been accelerated, significantly...
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Palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes: a strain release approach toward alkylidenecyclobutanes
Available online 16 November 2024
A palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes with amines is described. This protocol is featured with its novel activation model, broad substrate scope and mild reaction conditions,...
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Synthesis of indoles, indolines, and carbazoles via palladium-catalyzed C–H activation
May 2021
The construction of indole, indoline and carbazole heterocycles has been of significant interest in the synthetic community over the last century due to their prevalence in natural products and other...
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Recent advances in visible-light photoredox-catalyzed nitrogen radical cyclization
June 2020
Visible-light photoredox catalysis is a powerful and attractive strategy for organic molecule activation and new reaction design owing to its environmental-friendly characteristics and unique catalytic...
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Enhancement of CO2 hydrogenation to formate using formate dehydrogenase immobilized on UiO66 and its derivatives
Available online 23 September 2024
In the present work, a highly stable zirconium-based metal-organic framework (MOF), UiO66, and its derivative, UiO66-NH2, were tested as support materials to immobilize Formate dehydrogenase (FDH) for...
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Recent advances in (4 + 3) cycloaddition of allenes
November 2024
Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 + 3) cycloaddition reaction...
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Electrocatalytic regio- and stereoselective carboxylation of terminal alkynes with CO2
Available online 30 November 2024
Carboxylation with CO2 is a practical and streamlined way to construct a variety of sophisticated carboxylic acids and their derivatives. However, a series of elegant methods focus mainly on C(sp3)–...
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Synthesis of 5-hydroxymethylfurfural from dehydration of biomass-derived glucose and fructose using supported metal catalysts
May 2021
The global energy shortage has become more and more serious, which promotes the urgent need to shift to sustainable development. The value-added 5-hydroxymethylfurfural (HMF) can be derived from biomass...
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