In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy
April 2025
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are therapeutic targets associated with Alzheimer's disease. In this study, we focused on bioactive compounds from Aloe vera leaves,...
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
December 2024
This comprehensive review investigates the cutting-edge tools and technologies that are revolutionizing modern pharmaceutical research. We analyze the integration of artificial intelligence and machine...
Advances in drug discovery based on network pharmacology and omics technology
December 2024
Drug discovery plays a crucial role in cancer treatment. Traditional drug discovery methods mainly rely on in vivo animal experiments and in vitro drug screening, which are not only costly but also...
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
December 2024
The application of multi-omics in drug discovery is rapidly advancing, but its trends and hotspots have not been fully analyzed. By reviewing key achievements and research hotspots in this field, the...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
Design, synthesis, and therapeutic potential of pyridazinone-based molecules: An updated comprehensive review
August 2025
Drug discovery involves the design, synthesis and pharmacological evaluation of new chemical entities. Heterocyclic compounds are ring structures in which a carbon atom is replaced by heteroatoms such...
Analytical advances in the quantitative and qualitative determination of clonidine and methyldopa: A review
January 2026
Clonidine and methyldopa are centrally acting antihypertensive agents that lower blood pressure by stimulating α₂-adrenoceptors in the brain stem, thereby reducing sympathetic outflow. While clonidine...
Wastewater-based epidemiology for monitoring cocaine and cannabis: A review of methods and applications
April 2026
Wastewater-based epidemiology (WBE) is an effective tool for monitoring public health, drug use, chemical exposure, and lifestyle habits. This review summarises and discusses analytical protocols for...
Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review
March 2025
This review looks at the latest developments in some analytical techniques employed for impurity profiling and forced degradation studies for sartans, or angiotensin (AT1) receptor blockers, which are...
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy
April 2025
The objective of this project was to create a microsponge gel loaded with apigenin to improve medication release to treat angioedema....
Network pharmacology, molecular docking, and molecular dynamics simulation in drug development: A comprehensive perspective
September 2025
Method Development and validation for determination of Parthenolide in mice plasma using reverse phase high performance liquid chromatography
September 2025
For accurate, fast, and selective determination of PTL, a RP-HPLC method was developed and validated. The objective of the study is to develop a reverse-phase high-performance liquid chromatography...
Nigellidine from Nigella sativa Targets AKT1 and GAPDH in rectal cancer: Insights from network pharmacology and molecular dynamics simulations
March 2026
Rectal cancer continues to pose a significant therapeutic challenge, underscoring the need for novel multi-target treatment strategies. Nigella sativa is rich in bioactive phytochemicals with reported...
Stability of Ketamine-Xylazine-Butorphanol formulation to establish an evidence-based beyond-use date
March 2026
A combination injection formulation containing 8.3 % w/v ketamine (K), 0.83 % w/v xylazine (X), and 0.083 % w/v butorphanol (B) is frequently used for sedation and anesthesia in New World Camelids....
Exploring the therapeutic effect of flavonoids on kidney health
June 2025
Chronic kidney disease (CKD) is a progressive systemic disease that changes the function and structure of the kidneys irreversibly over months or years. The final common pathological manifestation of...
Method development and validation of orlistat by using RP-HPLC
June 2025
To accurately quantify orlistat, an anti-obesity drug that is a pancreatic lipase inhibitor thus Depending on the assay system, orlistat illustrates studies at intestines receptors by temporarily blocking...
The role of Ursolic acid, a pharmacologically active compound from Ocimum sanctum L. as a potential chemotherapeutic agent
February 2025
The global cancer burden is predicted to rise by 40 % around the year 2030. Cancer-related mortality is exacerbated by the fact that the disease is becoming increasingly resistant to standard treatments....
Advances in electroanalytical techniques for pharmaceuticals and biological samples: Insights from the last decade
March 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
Immunomodulatory and skin-compatible effects of Amaranthus retroflexus volatile compounds: An in-silico network and pathway-based approach
January 2026
This study investigated the phytochemical profile, in silico skin sensitization, cosmetic toxicity, and endocrine-disrupting potential of compounds from Amaranthus retroflexus identified through GC-MS...
Sponging innovations: A new era of porous nanocarriers in drug delivery and biomedical applications
March 2026
Nanosponges (NSs) are highly crosslinked porous, colloidal carriers that possess a unique three-dimensional, sponge-like structure. It is this special structure that enables them to entrap a broad range...
Nutraceuticals potential of Zingiber officinale and Linum usitatissimum: A comprehensive analysis of macroscopic, microscopic, physico-chemical and phyto-chemical properties
February 2025
Ginger (Zingiber officinale) and flaxseed (Linum usitatissimum) demonstrate a diverse spectrum of anti-inflammatory and antioxidant properties, with therapeutic applications in integrative medicine,...
Effects of different doses of esketamine combined with propofol on gastrointestinal endoscopy in elderly patients
March 2026
Propofol alone for painless gastroscopy/colonoscopy in elderly patients causes frequent movement and respiratory depression due to poor analgesia. Esketamine, the only intravenous anesthetic with analgesic...
Integrating metabolomics, DPPH assay, and literature mining for quality marker prediction and the establishment of a quality control strategy for Ampelopsis grossedentata
January 2026
A member of Vitaceae, Ampelopsis grossedentata (AG) is well-studied for its rich phytochemistry and bioactivities, indicating high medicinal value; yet, a reliable method for comprehensive quality control...
Identification of potential anti-tubercular inhibitors through virtual screening, DFT, and molecular dynamics simulation studies
January 2026
Tuberculosis (TB) continues to pose a significant threat to global health, a problem intensified by the rise of strains of Mycobacterium tuberculosis that resist multiple drugs. Identifying novel inhibitors...
