Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
December 2024
This comprehensive review investigates the cutting-edge tools and technologies that are revolutionizing modern pharmaceutical research. We analyze the integration of artificial intelligence and machine...
Advances in drug discovery based on network pharmacology and omics technology
December 2024
Drug discovery plays a crucial role in cancer treatment. Traditional drug discovery methods mainly rely on in vivo animal experiments and in vitro drug screening, which are not only costly but also...
In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy
April 2025
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are therapeutic targets associated with Alzheimer's disease. In this study, we focused on bioactive compounds from Aloe vera leaves,...
Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
December 2024
The application of multi-omics in drug discovery is rapidly advancing, but its trends and hotspots have not been fully analyzed. By reviewing key achievements and research hotspots in this field, the...
Quantitative determination of combination of amlodipine besylate and telmisartan in tablets using 1H-qNMR and its comparison to HPLC for further validation
May 2026
HPLC and LC–MS are traditional drug-analysis methods, while 1H-qNMR is increasingly popular as it is a non-destructive technique which does not require standards and enables efficient analysis of complex...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
In silico design of some potent antioxidant compounds using 2D-QSAR, molecular docking and ADMET studies
May 2026
Oxidative stress caused by free radicals plays a major role in the development of ageing and several degenerative disorders, including cancer, cardiovascular diseases, diabetes, and Alzheimer’s disease....
Design, synthesis, and therapeutic potential of pyridazinone-based molecules: An updated comprehensive review
August 2025
Drug discovery involves the design, synthesis and pharmacological evaluation of new chemical entities. Heterocyclic compounds are ring structures in which a carbon atom is replaced by heteroatoms such...
Wastewater-based epidemiology for monitoring cocaine and cannabis: A review of methods and applications
April 2026
Wastewater-based epidemiology (WBE) is an effective tool for monitoring public health, drug use, chemical exposure, and lifestyle habits. This review summarises and discusses analytical protocols for...
Analytical advances in the quantitative and qualitative determination of clonidine and methyldopa: A review
January 2026
Clonidine and methyldopa are centrally acting antihypertensive agents that lower blood pressure by stimulating α₂-adrenoceptors in the brain stem, thereby reducing sympathetic outflow. While clonidine...
Research progress of liquid chromatography-mass spectrometry in therapeutic drug monitoring of antipsychotic drug: A review of the past decade
October 2025
Antipsychotic drugs (AD) are important for managing psychiatric disorders like schizophrenia and bipolar disorder, however, their clinical use is often complicated by narrow therapeutic windows, variable...
Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review
March 2025
This review looks at the latest developments in some analytical techniques employed for impurity profiling and forced degradation studies for sartans, or angiotensin (AT1) receptor blockers, which are...
The pharmacological actions of berberine: From a traditional medicine to modern polypharmacology
April 2026
Jiawei Guilu Erxian Decoction enhances CD8⁺ T-cell activation and cytotoxicity via JNK/c-JUN activation to suppress non-small cell lung cancer tumor growth in vivo
April 2026
The immunological effects of Jiawei Guilu Erxian Decoction (JGED) in non-small cell lung cancer (NSCLC) have not been fully defined. This study investigated whether JGED influences CD8⁺ T-cell activity...
Computational design and evaluation of novel thienopyrimidine PI3Kδ inhibitors for diffuse large b-cell lymphoma: QSAR, docking, molecular dynamics, and density functional theory studies
April 2026
Phosphoinositide 3-kinase delta (PI3Kδ) is a key regulator of B-cell receptor signalling and a validated therapeutic target in diffuse large B-cell lymphoma (DLBCL). The development of selective and...
Implementation of analytical quality by design (AQbD) in RP-HPLC method development for quantification of allopurinol in pure and commercial formulations
June 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Exploring the therapeutic effect of flavonoids on kidney health
June 2025
Chronic kidney disease (CKD) is a progressive systemic disease that changes the function and structure of the kidneys irreversibly over months or years. The final common pathological manifestation of...
Screening the effective metabolites of Mosla soochowensis Matsuda on LPS-induced inflammation in RAW264.7 cells by integrated LC-triple TOF-MS/MS and network pharmacology
April 2026
Mosla soochowensis Matsuda (MSM) is a traditional Chinese herbal medicine empirically used for treating inflammatory conditions such as tonsillitis and the common cold. Previous studies focused solely...
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy
April 2025
The objective of this project was to create a microsponge gel loaded with apigenin to improve medication release to treat angioedema....
Nutraceuticals potential of Zingiber officinale and Linum usitatissimum: A comprehensive analysis of macroscopic, microscopic, physico-chemical and phyto-chemical properties
February 2025
Ginger (Zingiber officinale) and flaxseed (Linum usitatissimum) demonstrate a diverse spectrum of anti-inflammatory and antioxidant properties, with therapeutic applications in integrative medicine,...
Network pharmacology, molecular docking, and molecular dynamics simulation in drug development: A comprehensive perspective
September 2025
The role of Ursolic acid, a pharmacologically active compound from Ocimum sanctum L. as a potential chemotherapeutic agent
February 2025
The global cancer burden is predicted to rise by 40 % around the year 2030. Cancer-related mortality is exacerbated by the fact that the disease is becoming increasingly resistant to standard treatments....
Ginger oil based solid self nanoemulsifying drug delivery system of etoricoxib with improved oral bioavailability
May 2026
Etoricoxib is a selective cyclooxygenase 2 inhibitor with limited aqueous solubility and low oral bioavailability. The present study aimed to develop a ginger oil-based solid self-nanoemulsifying drug...
Advances in analytical strategies for fixed-dose gliflozin combinations: A comprehensive evaluation
April 2026
Fixed-dose combinations (FDCs) containing gliflozin derivatives have become important therapeutic options in type 2 diabetes, offering complementary mechanisms and improved treatment adherence. Their...
