Implementation of analytical quality by design (AQbD) in RP-HPLC method development for quantification of allopurinol in pure and commercial formulations
June 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Current Status and Prospects of Microbial Ecology and Detection Strategies in Pharmaceutical Water Systems
Available online 3 July 2026
Pharmaceutical water systems constitute a critical utility within the pharmaceutical manufacturing. Water plays a pivotal role in various stages—including synthesis, formulation, and cleaning—yet simultaneously...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
December 2024
This comprehensive review investigates the cutting-edge tools and technologies that are revolutionizing modern pharmaceutical research. We analyze the integration of artificial intelligence and machine...
Advances in drug discovery based on network pharmacology and omics technology
December 2024
Drug discovery plays a crucial role in cancer treatment. Traditional drug discovery methods mainly rely on in vivo animal experiments and in vitro drug screening, which are not only costly but also...
Phytoconstituent based formulations and phenolic compounds in acne management with a comprehensive review of traditional remedies, modern strategies, and therapeutic innovations
July 2026
Acne vulgaris, a prevalent dermatological disorder, has traditionally been managed with pharmacological treatments, but there is a growing interest in herbal remedies due to their perceived safety and...
Ion-pair chromatography in pharmaceutical analysis: A practical guide to method development
July 2026
Ion-pair chromatography (IPC) has emerged as a complementary analytical tool, for the analysis of polar and ionizable compounds poorly retained under conventional chromatographic conditions. Its versatility...
Implementation of QbD approach in RP-HPLC method optimization and validation for concurrent estimation of Deflazacort and Tamsulosin hydrochloride under ICH Q14 and Q2R2 framework
November 2025
The simultaneous estimation of Tamsulosin Hydrochloride (TAM) and Deflazacort (DEF) in capsule dosage form requires a reliable analytical method. Reverse-phase high-performance liquid chromatography...
From chemometrics to foundation models in pharmaceutical analysis: Current evidence, limitations, and future directions
September 2026
Pharmaceutical analysis has always been shaped by a careful dialogue between measurement and meaning. Early chemometric approaches brought structure to this dialogue, allowing scientists to uncover...
Development and formulation of anti-diabetic capsules containing extract of E. denticulatum: Physicochemical study, encapsulation, and release kinetics
September 2026
Eucheuma denticulatum has been widely used to treat diabetes mellitus due to its several antidiabetic components. The current study aimed to formulate capsules containing the crude extract of E. de...
HPLC determination of two oxidative degradation impurities in exemestane active pharmaceutical ingredient
September 2026
Exemestane is prone to oxidative degradation, forming structurally similar isomeric impurities. This study established an high-performance liquid chromatography (HPLC) method for the determination of...
Identification of key molecular targets and mechanism of action in acute kidney injury by integrating network pharmacology and molecular docking
January 2026
Acute kidney injury (AKI) is a frequent renal complication in surgical settings. This study aimed to identify key molecular targets for AKI and to elucidate the mechanism of action of drugs that targeted...
Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
December 2024
The application of multi-omics in drug discovery is rapidly advancing, but its trends and hotspots have not been fully analyzed. By reviewing key achievements and research hotspots in this field, the...
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy
April 2025
The objective of this project was to create a microsponge gel loaded with apigenin to improve medication release to treat angioedema....
Research progresses on natural product monomers in the treatment of rheumatoid arthritis
July 2026
Rheumatoid arthritis (RA) is a chronic autoimmune disease with substantial global health implications. Although conventional synthetic disease modifying antirheumatic drugs (DMARDs) afford symptomatic...
Advances in electroanalytical techniques for pharmaceuticals and biological samples: Insights from the last decade
March 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
In silico design of some potent antioxidant compounds using 2D-QSAR, molecular docking and ADMET studies
May 2026
Oxidative stress caused by free radicals plays a major role in the development of ageing and several degenerative disorders, including cancer, cardiovascular diseases, diabetes, and Alzheimer’s disease....
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
Exploring the mechanism of dandelion in treating helicobacter pylori-induced chronic gastritis based on network pharmacology
September 2026
Helicobacter pylori-induced chronic gastritis (HAG) is a significant healthcare burden in China due to its prevalence and carcinogenic potential. Current clinical management relies on antimicrobial...
Design, synthesis, and therapeutic potential of pyridazinone-based molecules: An updated comprehensive review
August 2025
Drug discovery involves the design, synthesis and pharmacological evaluation of new chemical entities. Heterocyclic compounds are ring structures in which a carbon atom is replaced by heteroatoms such...
Quality markers of GFDH pills based on multi-component qualitative and quantitative analysis combined with network pharmacology and chemometric analysis
September 2026
Guifu Dihuang (GFDH) Pills is a classic traditional Chinese medicine prescription for kidney yang deficiency. At present, its quality control only takes Paeonol as the single marker, which is difficult...
Method Development and validation for determination of Parthenolide in mice plasma using reverse phase high performance liquid chromatography
September 2025
For accurate, fast, and selective determination of PTL, a RP-HPLC method was developed and validated. The objective of the study is to develop a reverse-phase high-performance liquid chromatography...
Bioinformatics and artificial intelligence for the discovery of food-derived bioactive compounds with health applications: Current advances and future perspectives
October 2026
Food-derived bioactive compounds have attracted considerable attention because of their ability to modulate biological pathways involved in chronic disease prevention and management. However, the remarkable...
Analytical approaches for the quantification of dipyridamole in various matrices: A comprehensive review
July 2026
Dipyridamole (DPD) is a crucial antiplatelet and vasodilatory agent widely used to prevent thromboembolic disorders and stroke; however, its quantitative assay remains challenging due to poor solubility,...
In silico discovery of novel benzenesulfonamide-tetrahydropyrimidine hybrids as dual target inhibitors of EGFR and thymidylate synthase
September 2026
Breast cancer remains a major global health challenge, characterized by high heterogeneity and frequent resistance to single-target therapies. Multi-target drug design offers a promising strategy to...