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RNA-binding protein Roq modulates the Drosophila STING antiviral immune response
March 2025
The STING (stimulator of interferon genes) signaling pathway plays a pivotal role in the immune defense against viral infections in a wide range of vertebrates and invertebrates. However, the regulatory...
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Increased co-expression of CTLA4/LAG3 predicted adverse clinical outcomes in patients with T-cell malignancies
March 2025
The application of immune checkpoint blockers (ICBs) in immunotherapy has markedly improved the prognosis for patients with solid tumors and B-cell lymphomas, and it holds promise as a novel therapeutic...
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The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options
March 2025
Brain metastases (BM), in which cells from a primary malignant tumor spread through the circulatory system into the microvasculature of the brain, eventually progress despite multiple therapeutic programmes...
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Antioxidant dipeptide, cyclo (Phe-Phe), protects against bone dysplasia by suppression of phospholipid peroxidation
Available online 26 November 2024
Prenatal exposure to dexamethasone (Dex) has been identified as a significant factor that impairs longitudinal skeletal growth in fetuses, resulting in notable deficiencies in bone development. However,...
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