Special Issue on Immune and Peri-vascular Cells in Brain Hemorrhage

Introduction:

Brain hemorrhage is a clinical emergency caused by bleeding in the central nervous system (CNS). Depending on the location where hemorrhage occurs, it can be broadly categorized into intracerebral hemorrhage and subarachnoid hemorrhage. Both types of brain hemorrhage have high mortality and morbidity rates. Although much effort has been put into the investigation brain hemorrhage, the underlying molecular mechanisms are not yet fully understood, and effective therapies remain urgently needed.

Immune cells, including brain resident microglia, CNS-associated macrophages and peripheral leukocytes, actively regulate disease pathology and outcomes. In addition, peri-vascular cells, including mural cells and fibroblasts, also play important roles in disease progression.

The aims of this Special Issue are to summarize current findings and opinions on the functions of immune cells and peri-vascular cells in brain hemorrhage, stimulate research interests in this field, and promote the development of novel treatments for brain hemorrhage.

Topics covered (not limited):

• Immune-CNS interactions in physiological conditions and after brain hemorrhage.
• Blood-brain barrier in brain hemorrhage.
• Role and mechanism of immune cells, such as microglia and macrophages, in the pathogenesis of brain hemorrhage.
• Role and mechanism of peri-vascular cells, including mural cells and fibroblasts, in the pathogenesis of brain hemorrhage.
• Immune cell- and peri-vascular cell-based therapeutic strategies for brain hemorrhage.
• Novel in vitro and in vivo models for brain hemorrhage.
• Novel biotechnology and treatments for brain hemorrhage.

Important Deadlines:

• Submission deadline:31 December 2024.

Submission Instructions:

Please read the [Guide for Authors] before submitting. All articles should be submitted online, please select VSI: New Insights in Stroke on submission. 

Guest Editors:

Professor Yao Yao, University of South Florida, USA, yao7@usf.edu