Organ-on-chip technology: Opportunities and challenges
2024
Organ-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes....
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A comprehensive study on anaerobic digestion of organic solid waste: A review on configurations, operating parameters, techno-economic analysis and current trends
2024
The excessive discharge and accumulation of solid organic waste into the environment is of severe concern across the globe. Thus, an efficient waste management system is important to mitigate health...
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Decoding dye degradation: Microbial remediation of textile industry effluents
2023
The extensive use of chemical dyes, primarily Azo and anthraquinone dyes, in textiles has resulted in their alarming release into the environment by textile industries. The introduction of heavy metals...
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Ribosome purification from Escherichia coli by ultracentrifugation
2022
With more and more researchers conducting extensive research on all aspects of ribosomes, how to extract ribosomes with good effect and high activity has become a fundamental problem. In this article,...
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Unlocking the potential of biosurfactants: Innovations in metabolic and genetic engineering for sustainable industrial and environmental solutions
2024
Biosurfactants, synthesized by microorganisms, hold potential for various industrial and environmental applications due to their surface-active properties and biodegradability. Metabolic and genetic...
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The potential of copper oxide nanoparticles in nanomedicine: A comprehensive review
2024
Nanotechnology is a modern scientific discipline that uses nanoparticles of metals like copper, silver, gold, platinum, and zinc for various applications. Copper oxide nanoparticles (CuONPs) are effective...
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The future of cell-free synthetic biology
2024
Cell-free synthetic biology aims at the targeted replication, design, and modification of life processes in open systems by breaking free of constraints such as cell membrane barriers and living cell...
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Synthetic biology in Europe: current community landscape and future perspectives
2022
Synthetic biology has captivated scientists' imagination. It promises answers to some of the grand challenges society is facing: worsening climate crisis, insufficient food supplies for ever growing...
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Development of destabilized mCherry fluorescent proteins for applications in the model yeast Saccharomyces cerevisiae
2022
Fluorescent proteins are widely used molecular reporters in studying gene expression and subcellular protein localization. To enable the monitoring of transient cellular events in the model yeast Saccharomyces...
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Circular mRNA: A novel therapeutic agent
2023
Circular mRNA (circmRNA) is a covalent closed loop formed by reverse splicing of the 3′ end to the 5′ end of mRNA. Compared to traditional linear mRNAs, circmRNAs can mediate efficient, stable, and...
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Unraveling current breakthroughs in Scorodocarpus borneensis phytochemical therapeutics: A systematic review
2024
Scorodocarpus borneensis, also known as the Kulim tree or Garlic tree, has been consumed by the local communities in Southeast Asia as traditional spice using its old leaves, stem bark, and seeds. The...
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Identifying Chlorella vulgaris and Chlorella sorokiniana as sustainable organisms to bioconvert glucosamine into valuable biomass
2024
Chitin is a major component of various wastes such as crustacean shells, filamentous fungi, and insects. Recently, food-safe biological and chemical processes converting chitin to glucosamine have been...
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Synthetic biology in Indonesia: Potential and projection in a country with mega biodiversity
2023
Synthetic biology has gained many interest around the globe in the last two decades, not only due to its rapid development but also the potential to provide addressable solutions using standardized...
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Metabolic engineering of Escherichia coli to utilize methanol as a co-substrate for the production of (R)-1,3-butanediol
2023
Due to its abundance, cost-effectiveness, and high reducibility, methanol has gained considerable attention in the biomanufacturing industry as a nonfood feedstock for the production of value-added...
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Understanding virus retention mechanisms on protein a chromatography based on using different wash buffers – Evaluating the possibility for a generic wash buffer toolbox to improve virus clearance capacity
2024
During manufacturing of mammalian-cell derived monoclonal antibodies (mAbs) virus clearance capacity of the downstream process has to be demonstrated. The protein A chromatography step typically achieves...
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Construction of an ultra-strong PtacM promoter via engineering the core-element spacer and 5′ untranslated region for versatile applications in Corynebacterium glutamicum
2022
As one of the most important synthetic biology elements in transcriptional regulation, promoters play irreplaceable roles in metabolic engineering. For the industrial microorganism Corynebacterium glutamicum,...
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Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles
2024
Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs,...
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Incorporating omics-based tools into endophytic fungal research
2024
Fungal endophytes are valuable sources of bioactive compounds with diverse applications. The exploration of these compounds not only contributes to our understanding of ecological interactions but also...
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Hyperuricemia and the small intestine: Transport mechanisms and co-morbidities
2022
There is a global increase in cases of hyperuricemia over the last 10 years. A critical component of serum uric acid control is the transport of uric acid to the intestinal lumen, which accounts for...
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CRISPR/Cas9 improves targeted knock-in efficiency in Aspergillusoryzae
2024
Aspergillus oryzae is an important fungus in food and industrial enzyme production. In A. oryzae, targeted knock-in transformation is primarily limited to homologous recombination (HR)-based systems,...
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Engineered microbial consortia for next-generation feedstocks
2024
Addressing urgent environmental challenges, this commentary emphasizes the need for green, bio-based solutions in chemical production from renewable feedstocks. It highlights advanced metabolic engineering...
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aXonica: A support package for MRI based Neuroimaging
2024
Magnetic Resonance Imaging (MRI) assists in studying the nervous system. MRI scans undergo significant processing before presenting the final images to medical practitioners. These processes are executed...
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Synthetic biology landscape in the UK
2022
The UK is home to a vibrant and diverse synthetic biology community. Many of its successes in research innovation and technological commercialisation can be attributed to a strong base of dedicated...
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Antibiotic susceptibility and virulence factors of bacterial species among cancer patients
2024
Antibiotic resistance is one of the most significant challenges of the 20-s century, and the misuse of antibiotics is a driver of antimicrobial resistance. This study aimed to assess the prevalence...
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Exploration on the expression and assembly of virus-like particles
2021
Virus-like particles (VLPs) have a great application prospect in vaccines and molecule delivery carriers. In this study, in order to solve the problem of low expression and low assembly efficiency of...
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