Gold nanoclusters-incorporated nanogels as hybrid nanozymes for sensitive chemiluminescence immunoassays
December 2024
Nanomaterials with excellent biocompatibility hold significant potential in chemiluminescence (CL) immunoassays. However, achieving green synthesis and maintaining the structural stability of such nanomaterials...
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Advances in the molecular diagnostic methods for circular RNA
December 2024
Circular RNA (circRNA) is a unique type of non-coding RNA, which is produced by back splicing of mRNA to form the covalent junction without 3′-5′ polarity and poly(A) tail. With the development of detection...
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An aptamer-based point-of-care diagnostic test strip for rapid diagnosis of surface spike proteins of SARS-CoV2 virus
September 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has been identified as the causative agent for the COVID-19 pandemic. Herein, we report the development of a point-of-care diagnostic (POC)...
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A comprehensive study on epigenetic signatures to monitor disease progression and the response to therapy in breast cancer
September 2024
Breast cancer is the single most complex cancer type, affecting thousands around the globe annually. With the recent studies highlighting epigenetic signatures in breast cancer detection, this landscape...
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Optical pickup unit-based fluorescence microscope with autofocus and deep learning capabilities
September 2024
An autofocus, cost-effective fluorescence microscope instrument is made using a commercially available Blu-ray disc optical pickup head (OPU). This ABFM consists of the optical path, system control...
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An ensemble machine learning-based approach to predict thyroid disease using hybrid feature selection
September 2024
Thyroid issues are becoming more and more common, and early detection is critical for therapy that reduces mortality and complications. Because of these factors, detecting thyroid problems has become...
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Halogenated 2,4-diphenyl indeno[1,2-B]pyridinol derivatives as potential inhibitors of the androgen receptor (PDB ID: 58TE): A study of QSAR modeling, molecular docking, and pharmacokinetics for prostate cancer treatment
September 2024
The present research was centered on the development of a predictive model aimed at assessing the responses of prostate tumors to a range of compounds within the scope of the pIC50 project. Our approach...
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Copper ions amplify the oxidative stress caused by calcium overload leading to apoptosis
June 2024
Reactive Oxygen Species (ROS) therapy based on metal ion catalysis had attracted much attention due to its high selectivity for tumour cells and lower side effects. Copper ions (Cu2+) show great potential...
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Hanning FIR window filtering analysis for EEG signals
June 2024
The window function is a mathematical function in signal processing that is multiplied by a signal to lessen or eliminate the impact of undesired characteristics such as spectral leakage and edge effects...
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The dawn of spatiotemporal transcriptomics
June 2024
Gene expression of cells in the tissues is a heterogeneous and dynamic program across space and time. Spatiotemporal transcriptomics technologies have emerged as transforming tools to dissect the spatiotemporal...
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Industry 4.0 and circular economy for bolstering healthcare sector: A comprehensive view on challenges, implementation, and futuristic aspects
June 2024
Industry 4.0 technologies are also strengthening the circular economy and circular healthcare. It is accomplished by implementing methods to reduce waste and undertake advanced sustainability initiatives....
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A comprehensive study on epigenetic biomarkers in early detection and prognosis of Alzheimer's disease
June 2024
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques and tau tangles, disrupting brain cell communication, causing atrophy, and leading to cognitive decline....
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Aptamer-carbon quantum dots and silver nanoparticles construct a FRET sensor for sensitive detection of E. coli
June 2024
E. coli is considered to be one of the most dangerous foodborne pathogens and precise detection of E. coli in food is required to ensure the quality and safety of food. In this work, carbon quantum...
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Chiral nanomaterials for neurodegenerative diseases
June 2024
Chiral nanomaterials with distinctive physical and chemical properties, including circular dichroism, circularly polarized photoluminescence, nonlinear optics, and spintronics, have risen to the forefront...
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Engineered exosome-based drug delivery system for synergistic cancer therapy via autophagy inhibition and chemotherapy
June 2024
Exosomes (EXOs) are a class of natural nanovesicles secreted endogenously by mammalian cells. Recent decades have witnessed the broad applications of exosomes in cancer diagnosis and treatment. In the...
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A target-triggered mimic nucleic acid enzyme enables versatile and sequence-independent biosensing
March 2024
Simultaneous quantification of multiple microRNAs (miRNAs) is very important because lots of pathologies are associated with abnormal expressions of several miRNAs. In this work, we proposed an enzyme-assisted...
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Enhancing biocompatible metal alloy fabrication for bio implants through laser-based additive manufacturing (LBAM)
March 2024
Creating metal alloys that are durable and biologically suitable for medical implants is a significant focus of current medical science. Investigate using Laser-Based Additive Manufacturing (LBAM) methods...
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Advances in fluorescence imaging of RNAs in living cells based on functional nucleic acid probes
March 2024
RNA is an essential biomolecule that determines and regulates numerous biological process in cells. The sensitive and specific imaging of the expression level, localization and dynamic change of RNAs...
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Dual-microRNA triggered and DNA-programmed nanomachine for subtype-based detection and tailored treatment of breast cancer cells
March 2024
Discriminative detection and precise therapy targeting specific subtypes of breast cancers are critical for improving the treatment efficacy and thereby improving the survival rates of patients. Herein,...
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Wearable Janus nanofiber membrane-based colorimetric sensors for directional transfer and analysis of sweat
March 2024
Wearable sweat sensors are promising for real-time personalized health monitoring in a noninvasive manner. However, how to improve the wearing comfort and accuracy affected by sweat accumulation and...
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The nature of PDMS affects the results of the immunoassays carried out in microfluidic channels
March 2024
Due to various physical or biochemical processes, the nature of polydimethylsiloxane (PDMS) could affect the sensitivity and accuracy of immunoassays performed in microfluidic channels. An appropriate...
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Electrochemical aptamer-based biosensing of glycan-conjugated targets
March 2024
As the most complex post-translational modification, glycosylation involves the covalent linking of glycan(s) to a biomolecule. The glycosylation of proteins, peptides, lipids, and nucleic acids results...
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