Highly-cited papers from Bioactive Materials in Mar 2025

Published 21 March, 2025

We are delighted to bring you 167 highly-cited papers from Bioactive Materials. The citations received by these highly-cited papers put them in the top 1% of papers based on a highly-cited threshold for the field and publication year.*

NO. Article Title
1 Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease
2 Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application
3 Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening
4 Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing
5 Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing
6 Biomedical applications of engineered heparin-based materials
7 Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
8 Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission
9 Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment
10 The horizon of bone organoid: A perspective on construction and application
11 A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair
12 Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis
13 Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing
14 Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration
15 3D bioactive composite scaffolds for bone tissue engineering
16 Bone grafts and biomaterials substitutes for bone defect repair: A review
17 Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade
18 Manganese molybdate nanodots with dual amplification of STING activation for cycle treatment of metalloimmunotherapy
19 From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy
20 Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation
21 Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration
22 Nanoparticles modified by polydopamine: Working as drug carriers
23 Photo-curing 3D printing technique and its challenges
24 DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules
25 Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects
26 Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
27 Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy
28 Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges
29 NK cell-based tumor immunotherapy
30 Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation
31 Sustained release of magnesium and zinc ions synergistically accelerates wound healing
32 A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody
33 A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing
34 Bioactive hydrogels for bone regeneration
35 Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions
36 Activation of pyroptosis by specific organelle-targeting photodynamic therapy to amplify immunogenic cell death for anti-tumor immunotherapy
37 Advances in orthodontic clear aligner materials
38 Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications
39 Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy
40 Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy
41 A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds
42 Collagen fibril-like injectable hydrogels from self-assembled nanoparticles for promoting wound healing
43 Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
44 ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation
45 Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes
46 Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
47 A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings
48 Heterogeneous DNA hydrogel loaded with Apt02 modified tetrahedral framework nucleic acid accelerated critical-size bone defect repair
49 Cartilage-inspired self-assembly glycopeptide hydrogels for cartilage regeneration via ROS scavenging
50 A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis
51 How far is Lignin from being a biomedical material?
52 Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries
53 A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy
54 Keratin - Based materials for biomedical applications
55 Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
56 Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury
57 Antibacterial gas therapy: Strategies, advances, and prospects
58 A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound
59 A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury
60 Nitrogen-doped fluorescence carbon dots as multi-mechanism detection for iodide and curcumin in biological and food samples
61 Integrating coaxial electrospinning and 3D printing technologies for the development of biphasic porous scaffolds enabling spatiotemporal control in tumor ablation and osteochondral regeneration
62 Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
63 Additively manufactured metallic biomaterials
64 An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing
65 Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering
66 Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
67 Microenvironment responsive nanocomposite hydrogel with NIR photothermal therapy, vascularization and anti-inflammation for diabetic infected wound healing
68 Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration
69 Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing
70 Microgel assembly: Fabrication, characteristics and application in tissue engineering and regenerative medicine
71 Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing
72 Exosome regulation of immune response mechanism: Pros and cons in immunotherapy
73 Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney
74 Polymeric dual-modal imaging nanoprobe with two-photon aggregation-induced emission for fluorescence imaging and gadolinium-chelation for magnetic resonance imaging
75 Tetrahedral framework nucleic acids-based delivery of microRNA-155 inhibits choroidal neovascularization by regulating the polarization of macrophages
76 Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
77 Bioinspired mineralized collagen scaffolds for bone tissue engineering
78 Bone/cartilage targeted hydrogel: Strategies and applications
79 Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis
80 An overview of filtration efficiency through the masks: Mechanisms of the aerosols penetration
81 Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing
82 Chitosan based bioactive materials in tissue engineering applications-A review
83 Black phosphorus nanosheets-enabled DNA hydrogel integrating 3D-printed scaffold for promoting vascularized bone regeneration
84 Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
85 The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment
86 A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds
87 Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects
88 Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments
89 3D printing of bio-instructive materials: Toward directing the cell
90 A review on current research status of the surface modification of Zn-based biodegradable metals
91 Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications
92 Biobased polyurethanes for biomedical applications
93 Advancing application of mesenchymal stem cell-based bone tissue regeneration
94 An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease
95 Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury
96 Functionalized liposomes for targeted breast cancer drug delivery
97 Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications?
98 Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
99 3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances
100 A nanoenzyme-modified hydrogel targets macrophage reprogramming-angiogenesis crosstalk to boost diabetic wound repair
101 M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator
102 Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens
103 Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing
104 Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold
105 Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization
106 Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis
107 Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
108 Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives
109 3D printing of bone tissue engineering scaffolds
110 Targeted therapy of kidney disease with nanoparticle drug delivery materials
111 Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications
112 Embedded 3D bioprinting - An emerging strategy to fabricate biomimetic & large vascularized tissue constructs
113 Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging
114 Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing
115 Gold@Halloysite nanotubes-chitin composite hydrogel with antibacterial and hemostatic activity for wound healing
116 Biomimetic AgNPs@antimicrobial peptide/silk fibroin coating for infection-trigger antibacterial capability and enhanced osseointegration
117 Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?
118 Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance
119 Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
120 Advanced hydrogels for the repair of cartilage defects and regeneration
121 Progress in regulating inflammatory biomaterials for intervertebral disc regeneration
122 3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration
123 Structural and biological engineering of 3D hydrogels for wound healing
124 Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis
125 Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration
126 Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances
127 Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality
128 Biofabrication methods for reconstructing extracellular matrix mimetics
129 AI-enabled organoids: Construction, analysis, and application
130 Breathable, antifreezing, mechanically skin-like hydrogel textile wound dressings with dual antibacterial mechanisms
131 Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration
132 Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression
133 Smart bioadhesives for wound healing and closure
134 Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
135 Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing
136 Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity
137 Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation
138 SERS sensing for cancer biomarker: Approaches and directions
139 Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives
140 Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment
141 Triple-synergistic MOF-nanozyme for efficient antibacterial treatment
142 Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing
143 Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering
144 Developing natural polymers for skin wound healing
145 Additively manufactured pure zinc porous scaffolds for critical-sized bone defects of rabbit femur
146 An overview of substrate stiffness guided cellular response and its applications in tissue regeneration
147 Additive manufacturing technology for porous metal implant applications and triple minimal surface structures: A review
148 In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity
149 Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair
150 Peptide-based nanomaterials: Self-assembly, properties and applications
151 Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
152 Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
153 Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds
154 Antibacterial metals and alloys for potential biomedical implants
155 Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel
156 Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
157 Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
158 An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury
159 Intravesical chemotherapy synergize with an immune adjuvant by a thermo-sensitive hydrogel system for bladder cancer
160 Research advances of nanomaterials for the acceleration of fracture healing
161 Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
162 Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis
163 An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing
164 Recent advances in biomaterials for 3D scaffolds: A review
165 Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor
166 Tailoring micro/nano-fibers for biomedical applications
167 Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

 

*Top 1% based on the number of citations received when compared to other papers published in the same field in the same year. Data from Essential Science Indicators.

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