EBM Interview: Hyung-Seop (Chris) Han

Biography

Professional Experience

• 2023-Present: Principal Research Scientist, KIST
• 2019-2023: Senior Research Scientist, Korea Institute of Science and Technology
• 2011-2018: Research Scientist at Korea Institute of Science and Technology
• 2009-2011: Student Trainee at Korea Institute of Science and Technology
• 2003-2006: The University of Iowa, Hospitals and Clinics ; Technology Assistant, Human Resource Division

Honors & Awards

• President’s Award from the Korean Intellectual Property Office
• The International Magnesium Association – “Award of Excellence”
• Clarendon Scholarship at University of Oxford (Top 1% of the all Graduate Student)
• Midental Award (Best Poster) at Korean Institute of Metals and Materials Spring 2013

Here is the interview we did with him

1. Could you briefly introduce your current research field?

My current research is centered on the clinical translation of bioactive and biodegradable materials. I specialize in developing innovative materials designed to be swiftly integrated into clinical settings. This involves not only creating novel materials but also collaborating with experts from diverse fields, such as green energy and artificial intelligence. These interdisciplinary partnerships are crucial for advancing new technologies that can be applied to various biomedical challenges. By bridging these different areas of expertise, I aim to accelerate the practical implementation of cutting-edge materials in healthcare and improve patient outcomes.

2. What obstacles or difficulties have you encountered in your research work? How did you overcome these difficulties?

In research, especially in the realm of clinical translation, encountering unforeseen challenges is a common experience. One of the primary obstacles is the extended timeline required to address unexpected outcomes, as any adverse results necessitate thorough investigation and validation to ensure safety before clinical trials can proceed. This is particularly critical given that bioactive and biodegradable materials must undergo rigorous cellular and animal testing to meet safety standards.

A significant challenge arises from the need for extensive testing and potential redesigns of the materials. Even minor adjustments can necessitate a complete overhaul of previous studies, which can be time-consuming and resource-intensive. To mitigate these issues, I have developed strategies to minimize foreseeable obstacles. For instance, I often begin the design process with FDA-approved raw materials, which helps in circumventing potential regulatory and clinical issues.

Despite these precautions, the inherent unpredictability of research means that not all challenges can be anticipated. Over time, I have learned to embrace this uncertainty as a fundamental aspect of the research process. Accepting that some unknowns are inevitable allows me to focus on adaptive problem-solving and continuous learning, which ultimately enhances the robustness and impact of my work. 

3. What attracted you to join the BAM editorial Board team?

My involvement with the biodegradable metal community dates back to its early days, beginning with my participation in the 2012 symposium on biodegradable metals. During that event, I had the privilege of meeting esteemed researchers such as Prof. Yufeng Zheng, Prof. Frank Witte, and Prof. Diego Mantovani. These early interactions were instrumental in shaping my research focus and fostering collaborative relationships.

Over the years, I have been deeply engaged in cutting-edge research aimed at the clinical translation of biodegradable metals. This ongoing collaboration with leading experts in the field naturally led to strong professional and personal connections with the current Chief and Associate Editors of the journal. Joining the BAM Editorial Board is a significant honor for me, as it represents an opportunity to contribute to a premier journal that is at the forefront of advancements in this dynamic and impactful field. My commitment to advancing biodegradable metals aligns seamlessly with the journal’s mission, and I am enthusiastic about the prospect of supporting its continued excellence.

4. What are your expectations for the future development of Bioactive Materials and its promotion of related fields?

I anticipate that the field of Bioactive Materials will continue to expand rapidly in response to emerging challenges such as an aging population and significant lifestyle changes. The potential of bioactive materials to enhance societal well-being and extend the quality of human life is immense. Current clinical trials involving these materials are paving the way for breakthroughs that could revolutionize treatment options and improve patient outcomes.

In preparation for this exciting future, I have been actively involved in promoting the field through the establishment of a company called elecell, which we launched in March. Our mission at elecell is to accelerate the commercialization of innovative biological and medical technologies, with a focus on improving healing time and promoting good health. We are working on several cutting-edge products, including an electrical stimulation-based wound treatment device, a natural product-based wound recovery cream, and an electrical stimulation-based muscle cell therapy. These innovations are designed to address pressing medical needs and contribute to a healthier future by leveraging the latest advancements in Bioactive Materials.

5. What is your greatest hobby outside of scientific work?

Outside of my scientific work, my greatest hobby is playing football, often known as "soccer" in the United States. I began playing at a very young age, and it has remained a significant part of my life ever since. I continue to play every Tuesday, as it provides a valuable outlet for stress relief and helps me maintain a balanced lifestyle.

Interestingly, football has also facilitated some of my most meaningful professional connections. For instance, I met Dr. Kang, an expert in 3D display and artificial intelligence, through our shared passion for the sport. This connection led us to collaborate on developing a 3D medical hologram display, which was subsequently acquired by a private company for $1 million. This experience highlights how personal interests can intersect with professional opportunities, fostering both personal growth and innovative advancements.

6. How do you balance scientific research work and personal life?

Balancing scientific research with personal life can be challenging, and I must admit that the boundaries between the two in my life are often quite fluid. My research is a profound passion, and it frequently permeates my thoughts, even outside of traditional work hours. I find myself continually reflecting on how various aspects of life could be applied to or enhance my research endeavors. Despite this integration, I strive to maintain a positive outlook and manage stress effectively. I believe that a constructive approach to work-life integration helps me remain open to new ideas and opportunities. Embracing this mindset allows me to blend my professional interests with personal experiences, fostering a sense of fulfillment and continuous growth.

While my approach may not fit the conventional notion of work-life balance, it reflects a commitment to both my research and personal development, ensuring that I stay motivated and engaged in all aspects of my life.

7. What do you think is the most important quality for researchers?

I believe that persistence is the most crucial quality for a researcher. While it may sound like a cliché, the value of hard work and unwavering dedication cannot be overstated. In research, success often hinges not just on intelligence or brilliance but on the willingness to persevere through challenges and setbacks. Persistent effort is essential for overcoming obstacles, refining ideas, and achieving meaningful results. I firmly believe in this principle and strive to impart this mindset to my students and postdoctoral researchers. Encouraging them to embrace persistence helps them navigate the complexities of research and realize their full potential, ultimately leading to greater innovation and progress in their work.

8. What advice do you have for young scholars who are determined to engage in scientific research?

While I may not feel fully qualified to offer extensive advice, I would emphasize the importance of enjoying both the journey and the process of scientific research. Research is a lifelong endeavor of exploring and searching for answers, and finding the right solutions can take time. Even if results don’t come immediately, I believe each step and discovery contributes to a larger, more meaningful picture. Additionally, I encourage young scholars to remain open to ideas and methodologies from other fields. Many significant breakthroughs have emerged from applying concepts originally developed for entirely different purposes. Embracing interdisciplinary approaches can lead to innovative solutions and new perspectives that enrich your research and drive progress.