#AI Reads Urine# Differential Diagnosis and Prognostic Stratification of Testicular Germ Cell Tumors With miRNA from body fluid including urine

This study focused on the role of miRNAs in testicular germ cell tumors (TGCT). Using data from 134 patients in the TCGA-TGCT database, comprehensive analyses were conducted. Seven upregulated and seven downregulated miRNAs were identified. The upregulated miRNA signature had a sensitivity/specificity of 0.94/1.0 (AUC = 0.98), and the downregulated one had 0.97/0.94 (AUC = 0.96). Their deregulated expression was strongly linked to AJCC stage and distant metastasis (p < 0.001).

The miRNA target network analysis demonstrated their involvement in regulating cancer processes like cell proliferation. Notably, both miRNA signatures were detectable in body fluids, with urine being of particular significance. This indicates the potential of using urine as a non-invasive medium for detecting these miRNAs, which could facilitate early diagnosis and prognostic assessment of TGCT. Overall, these findings suggest that the identified miRNA signatures hold promise for improving the differential diagnosis and prognostic stratification of TGCT in a non-invasive manner, with urine potentially serving as a valuable sample source for clinical applications.

Genes 2024, 15, 1649. https://doi.org/10.3390/genes15121649

Youhe Gao

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