Time-varying lifestyle and mental-ill health risk factors for the longitudinal development of daily activity limitations among middle-aged and older adults in Thailand
2024
The aim of this study was to assess the longitudinal association between lifestyle factors, mental ill-health indicators and activities of daily living (ADL) disability among ageing adults in Thailand....
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Osmotic stressors confer age-dependent resistance to heat stress in wild-type and daf-2 Caenorhabditis elegans
2024
Glucose has been shown to shorten lifespan in Caenorhabditis elegans. The connection of glucose to stress resistance in C. elegans, however, appears to be complex. We have shown glucose to be protective...
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Young and old animals “use” different strategies for adapting to the chronic effects of ethanol
2024
The study of the young and old animals’ adaptation characteristics to the chronic effect of ethyl alcohol provides a quick solution of problems in biomedicine and gerontology, such as the formation...
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The gerontological saga of antidiabetic biguanides: From ignorance to prudence via high hopes
2024
The history of the discoveries that shaped the current attitudes to the use of antidiabetic biguanides, mainly metformin, as antiaging agents is reviewed. An emphasis is made on the mounting evidence...
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Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells
2024
The role of the endoplasmic reticulum (ER) in aging processes has not attracted much attention of researchers, while this structure plays one of the central roles in the processes of intracellular synthesis....
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Are you feeling comfortable? – Measuring clinical hormesis
2024
Hormesis is a biological phenomenon where exposure to a low dose of a stressor or toxin induces a beneficial adaptive response, whereas higher doses may have detrimental effects. The concept of hormesis...
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Erlec1 controls bone metabolism by affecting osteoblast type I collagen synthesis
2024
Erlec1 gene has been suggested to be involved in the regulation of bone development. However, the underlying mechanism remains largely unknown. In this study, we showed that loss of Erlec1 leads to...
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Mechanistic insights of the anti-ageing dietary plant secondary metabolites vis-à-vis the modern hallmarks of ageing: Implications for developing novel anti-ageing foods
2024
Plant secondary metabolites (PSM) including polyphenols, alkaloids, and terpenes are diverse dietary influencers of human health that are also emerging as potent longevity modulators. However, the mechanistic...
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Body composition, fear of falling and balance performance in community-dwelling older adults
2023
We aimed to 1) assess body composition using a portable technology, bioelectrical impedance analysis, (BIA) and 2) examine the associations between body composition and the discrepancy of fear of falling...
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Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model
2023
Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency...
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The protective role of cognitive reserve on sleeping disorders on an aging population. A cross-sectional study
2023
Sleep disorders and depression have been identified as risk factors for aging-related problems. This cross-sectional studiy explored the protective role of the cognitive reserve on a sample of 377 healthy...
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Age-related changes of GAD1 mRNA expression in the central inferior colliculus
2023
Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related...
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Psychological stress and epigenetic aging in older men: The VA normative aging study
2023
Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older...
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Mitochondrial cardiomyopathy and emerging therapeutics
2023
Genetic mitochondrial cardiomyopathy (MCM) is a myocardial condition characterized by abnormal cardiac structure and function secondary to genetic defects. Severity can vary from asymptomatic to severe...
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Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration
2023
A prolonged healthy life is based on the optimal activity of an organism’s organ systems, and healthy cells are at the core of this proper functioning. Cellular homeostasis is of utmost importance,...
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Treatment mechanism of immune triad from the repurposing drug against COVID-19
2023
COVID-19 is an immune-mediated disease whose pathophysiology uses SAMHD1 tetramerization and cGAS–STING signaling, toll-like receptor 4 (TLR4) cascade, spike protein– inflammasome activation, and neuropilin...
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An updated landscape of cellular senescence heterogeneity: Mechanisms, technologies and senotherapies
2023
Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life. Senescent cells...
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Adrenergic innervation of thoracic lymphatic duct in postnatal ontogenesis
2023
The adrenergic innervation of the thoracic lymphatic duct was studied in young, mature and old animals. Adrenergic innervation of lymphatic system in postnatal ontogenesis, especially in its late period,...
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Subjective cognitive decline and cerebral-cognitive reserve in late age
2023
Determining the boundaries of the norm and pathology of mental aging is an urgent scientific task. We have formulated a hypothesis about the presence of a transitional period within the cognitive continuum,...
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The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals
2023
Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes). Excessive postprandial blood glucose spikes...
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Impact of frailty status on clinical outcomes in patients receiving peritoneal dialysis
2023
A cross-sectional analytical study was conducted for 88 patients receiving peritoneal dialysis (PD) in our centre over 13-months, to evaluate the ssociations between frailty and clinical outcomes within...
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The collaborative peer review framework as a model for training biomedical graduate students to perform rigorous, ethical peer review
2023
Peer review is an essential component of the academic publishing process, critical for the dissemination of new scientific information. Peer reviewers ensure that scientific assertions made in manuscripts...
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B and T cell subsets in elderly with frailty syndrome
2023
Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability...
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Rationale and design of STAMINA: Senolytics to alleviate mobility issues and neurological impairments in aging, a geroscience feasibility study
2023
The process of cellular senescence is hypothesized to play a critical role in the development of age-related mobility and cognitive impairments, both of which precede the development of Alzheimer's...
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Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's disease
2023
The underlying molecular mechanisms associated with sporadic Alzheimer's disease (AD), a progressive neurodegenerative disease, are not yet fully understood. Adult neurons are post-mitotic cells that...
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