Green polyurethanes from bio-based building blocks: recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers thanks to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable...
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies
Available online 6 May 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on carbonylation reactions have been published, summaries on cheap metal-catalyzed...
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Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Ate complexes in organic synthesis: From ate reagents to ate catalysts
August 2024
The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years, owing much to the evolution of ate complexes from mere reagents to versatile...
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Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
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Photocatalytic selective 1,4-oxyimination/diamination across C=C and N=N bonds to access structurally diverse N-N-N triazane derivatives
Available online 2 August 2024
A highly selective and atom-economical multi-component remote difunctionalization strategy has been successfully developed. This strategy utilizes precise control over the radical properties of bifunctional...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
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Recent advances in transition-metal-free conversion of aldehydes to ketones
Available online 3 May 2024
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines
August 2022
Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharmaceuticals, natural products, material science and organometallics. Due to their significant biological...
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1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
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Synthesis of 5-hydroxymethylfurfural from dehydration of biomass-derived glucose and fructose using supported metal catalysts
May 2021
The global energy shortage has become more and more serious, which promotes the urgent need to shift to sustainable development. The value-added 5-hydroxymethylfurfural (HMF) can be derived from biomass...
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Photochemical nitrene transfer reactions of iminoiodinanes with sulfoxides
Available online 15 May 2024
Nitrene, as an important and intriguing versatile synthon, is widely utilized for the formation of diverse nitrogenous skeletons under thermal or photochemical conditions. Typically, the N-sulfonyl...
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Synthesis of tetraarylmethanes: 1897–2022
November 2023
Tetraarylmethanes (TAMs) contain a carbon atom bound to four aryl groups. They have found diverse applications in chemistry, materials science, chemical biology and medicinal chemistry because of their...
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Synthesis of 1,4-oxathiins via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides
Available online 26 July 2024
A straightforward and valuable approach for the synthesis of 1,4-oxathiins has been developed via [3 + 3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides. C–S and C–O bonds...
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Synthesis of indoles, indolines, and carbazoles via palladium-catalyzed C–H activation
May 2021
The construction of indole, indoline and carbazole heterocycles has been of significant interest in the synthetic community over the last century due to their prevalence in natural products and other...
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Recent advances in visible-light photoredox-catalyzed nitrogen radical cyclization
June 2020
Visible-light photoredox catalysis is a powerful and attractive strategy for organic molecule activation and new reaction design owing to its environmental-friendly characteristics and unique catalytic...
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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
May 2023
C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past...
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Transition-metal-catalyzed transformations of C–N single bonds: Advances in the last five years, challenges and prospects
May 2021
Nitrogen atom widely exists in many organic molecules and biomacromolecules. Therefore, the formation and transformation of C–N bonds are one of the most attractive topics in organic synthetic chemistry....
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Development of catalyst-free carbon-sulfur bond formation reactions under aqueous media and their applications
November 2022
Methods for the carbon-sulfur bond formation under catalyst-free, aqueous conditions are extremely useful in organic synthesis and chemical biology. Our laboratory has developed methodologies to construct...
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