Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Green polyurethanes from bio-based building blocks: recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers thanks to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable...
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
Available online 19 December 2024
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
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Copper-catalyzed deuterodehalogenation of aryl halides
Available online 4 January 2025
There is growing potential and interest in the development of precise and practical deuterium labelling methodologies using an easy-handling deuterated source for alkylarenes and methylarenes. Here...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
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Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies
November 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on carbonylation reactions have been published, summaries on cheap metal-catalyzed...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Ate complexes in organic synthesis: From ate reagents to ate catalysts
August 2024
The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years, owing much to the evolution of ate complexes from mere reagents to versatile...
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes
Available online 10 January 2025
Hydrophosphination of α,β-unsaturated carbonyl compounds is one of the most common methods to prepare chiral phosphines. Herein, a copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes...
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Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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Stereoselective construction of atropisomers featuring a C–N chiral axis
May 2022
Atropisomeric C–N compounds belong to an important class of axially chiral compounds. However, whereas the asymmetric synthesis of biaryl atropisomers have been well established, general and efficient...
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Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis
June 2020
Asymmetric catalytic hydrogenations of imines and enamines with chiral transition-metal complexes bearing chiral ligands are among the most green and powerful approaches for the elaboration of chiral...
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Development of a more efficient catalyst for the redox-neutral organocatalytic mitsunobu reaction by DFT-guided catalyst design
November 2024
The study of a Mitsunobu reaction is an important topic. Denton and co-workers first reported a novel (2-hydroxybenzyl)diphenylphosphine oxide for realizing the catalytic Mitsunobu reaction via a five-membered...
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Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis
Available online 29 January 2025
A new type of asymmetric hydrogen atom abstraction catalysts, originated from the cinchona alkaloid family of natural products, has been successfully developed to access enantioselective epimerizations...
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Synthesis of dydrogesterone by aromatization-dearomatization strategy
Available online 15 December 2023
Dydrogesterone as an agonist of the progesterone receptor is an important and selective synthetic progesterone used for the treatment of a variety of conditions associated with progesterone deficiency...
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Recent advances in (4 + 3) cycloaddition of allenes
November 2024
Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 + 3) cycloaddition reaction...
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Copper-catalyzed aerobic photodecarboxylation of carboxylic acids to aldehydes and ketones
Available online 12 March 2025
Base-metal-catalyzed decarboxylative transformations provide an economic pathway to the efficient functionalization of carboxylic acids. Herein, a copper-catalyzed aerobic photodecarboxylation of carboxylic...
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