Effect of laparoscopic W-H versus Nissen-Rossetti fundoplication for proton pump inhibitor dependent gastroesophageal reflux disease: A multicenter randomized controlled trial protocol
April 2026
Our previous data showed that the W-H fundoplication had a similar mid-term satisfaction rate and a lower mid-term dysphagia rate compared with the Nissen-Rossetti fundoplication. But the results are...
Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer
April 2026
Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been...
Intermittent gastroduodenal intussusception: A rare indication for an elective Roux-en-Y gastric bypass
April 2026
Gastroduodenal intussusception is an extremely rare condition in adults, often associated with a pathological lead point such as a tumour. Given the paucity of case reports, it is generally difficult...
CRISPR-Cas-enabled nanocarriers in hepatocellular carcinoma: Emerging gene-editing strategies for precision liver therapy
April 2026
Hepatocellular carcinoma (HCC) remains a highly deadly global malignancy with limited curative treatments, frequent recurrence, and delayed diagnosis. Gene editing systems using CRISPR-Cas offer great...
Solitary hepatic abscess in a one-year-old: A diagnostic reminder in unexplained fever — a case report from Southwestern Tanzania
April 2026
A liver abscess (LA) is a pus-filled mass in the liver from either direct hepatic injury or infection spreading from the gastrointestinal tract via the portal vein. LAs are classified as pyogenic, amoebic,...
Liver cirrhosis: epidemiology, risk factors, potential complications, and possible treatment strategies
Available online 2 March 2026
In 2025, liver cirrhosis, characterized by hepatic fibrosis and regenerating nodules, with over 185 million individuals infected globally (>3% of the world population), represented a significant global...
Vitamin D Supplementation for Disease Activity and Maintenance of Remission in Inflammatory Bowel Disease:A Systematic Review and Meta-analysis
Available online 28 February 2026
Inflammatory bowel disease (IBD) has been linked to immune dysregulation and vitamin D deficiency, leading to growing interest in vitamin D supplementation as a potential adjunctive therapy. This systematic...
Current Evidence and Emerging Role of Endoscopic Bariatric and Metabolic Therapies in Gastrointestinal Endoscopy
Available online 28 February 2026
Obesity and related metabolic disorders, such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease(NAFLD) and dyslipidemia, are rising global health concerns. Traditional management...
The Gut-Brain Connection in Inflammatory Bowel Disease: Mechanisms, Mental Health, and Therapeutic Horizons
Available online 25 February 2026
Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic inflammatory condition that extends beyond the gut, affecting systemic and psychological health. The...
Exploring the effects of reflexology on gastrointestinal symptoms in Type-2 diabetic patients: A quasi-experimental study
January 2026
Type 2 diabetes is a growing global health concern, often leading to gastrointestinal complications that impact quality of life. Reflexology, a non-invasive therapy, may help alleviate these symptoms,...
Mutational analysis of exon 14 and 15 of the APC gene in esophageal squamous cell carcinoma in Mthatha-South Africa: A cross-sectional study
January 2026
Esophageal cancer is a major public health challenge in the Eastern Cape region of South Africa. Although changes in the APC gene are frequently implicated in various forms of cancer, few studies have...
Enhanced liver cancer detection: Leveraging pre-processing techniques for 3D CT volumes
January 2026
Accurate extraction and segmentation of the liver from medical images remain challenging due to the organ's irregular shape, similar intensity values to adjacent structures, variable contrast levels,...
Prevalence and association of small intestinal bacterial overgrowth with functional gastrointestinal disorders in children: A systematic review and meta-analysis
January 2026
Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathophysiology of functional gastrointestinal disorders (FGIDs), yet its prevalence and clinical relevance in children remain...
The impact of Ramadan fasting on the health of cirrhosis patients: A systematic review of available evidences
January 2026
Ramadan fasting is an annual obligation practiced by millions of Muslims worldwide. This practice is generally safe for healthy individuals, but the metabolic burden of this all-day fasting could cause...
A systematic review on gut microbiome and systemic sclerosis: Current evidence and future directions
January 2026
Systemic sclerosis (SSc) is an autoimmune disease characterized by diffuse organ fibrosis and nearly universal gastrointestinal (GIT) involvement, which impacts immune function, mucosal integrity, and...
Chronic alcohol and liver health: The gut-liver axis as a therapeutic target
January 2026
Chronic alcohol use has a substantial effect on liver health and general morbidity, making it one of the world's main causes of liver disease. Recent studies highlight the pivotal role of the gut-liver...
Evaluation of antiulcer activity of Launaea nudicaulis (L.) Hook.f (Gojihva) in experimental rat models
January 2026
The study aimed to evaluate the antiulcer activity of a 50 % hydroalcoholic extract of Launaea nudicaulis (L.) Hook.f (LN) using two experimental rat models: aspirin-induced gastric ulcer and aspirin...
The Human-AI Frontier: An in-depth exploration of physicians' apprehension and Outlook Towards Artificial Intelligence in gastroenterology healthcare
October 2025
Recent advances in artificial intelligence (AI) have transformed healthcare, offering potential in diagnosis, treatment, and patient management in gastroenterology. Understanding physicians' attitudes...
The frequency and characteristics of inflammatory bowel disease in pediatric patients with Hirschsprung's disease: A case-control study
October 2025
Hirschsprung disease is associated with enterocolitis and inflammatory bowel disease (IBD) as it affects bowel innervation from birth. This study is about the evaluation of IBD in children with diagnosed...
The role of artificial intelligence in ultrasonographic diagnosis of liver cancer: Current status and future perspectives
October 2025
With the rapid advancement of artificial intelligence (AI) technologies, ultrasonography has undergone transformative progress in the diagnosis of liver cancer. This review summarizes the latest developments...
Randomized controlled trials evaluating large language models in digestive diseases: a scoping review
October 2025
This scoping review summarizes the current landscape of randomized controlled trials (RCTs) evaluating the use of large language models (LLMs) in digestive diseases. We conducted a systematic search...
Multimodal learning in gastrointestinal diseases
October 2025
Gastrointestinal diseases represent a significant global health challenge, with current diagnostic and management approaches constrained by the integration of heterogeneous multimodal data. This review...
Research progress on the application of artificial intelligence in colonoscopy
October 2025
The global burden of colorectal diseases is steadily increasing, nderscoring the importance of early diagnosis, accurate assessment, and timely treatment. Despite being the standard for screening and...