Identification and the molecular mechanism of novel duck liver-derived anti-inflammatory peptides in lipopolysaccharide-induced RAW264.7 cell model
November 2024
In this study, 10 novel anti-inflammatory peptides were identified from duck liver, and their molecular mechanism was demonstrated based on machine learning and molecular docking. Using Sephadex G-15...
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The gut-liver axis mechanismf of increased susceptibility to non-alcoholic fatty disease in female offspring rats with prenatal caffeine exposure
November 2024
Caffeine intake during pregnancy is common, while its effect on gut microbiota composition of offspring and the relationship with susceptibility to adult diseases remains unclear. This study aimed to...
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Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome
November 2024
This study aimed to explore the protective effect and potential mechanism of Nostoc commune Vauch. polysaccharide (NCVP) on lead (Pb)-poisoning mice. NCVP improved Pb-induced hepatorenal toxicity and...
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Molecular mechanisms of bitterness and astringency in the oral cavity induced by soyasaponin
November 2024
The interaction mechanism between soyasaponin (Ssa) and bitter receptors/mucin, as well as the saliva interface behavior of Ssa, were investigated to explore the presentation mechanism of Ssa bitterness...
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Geroprotection from ergothioneine treatment in Drosophila melanogaster by improving intestinal barrier and activation of intestinal autophagy
November 2024
Ergothioneine is a natural amino acid with powerful antioxidant activity. Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis...
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Protective effects of Bifidobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway
November 2024
This study aimed to evaluate the effects of Bifidobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms. B. breve CCFM683 significantly ameliorated psoriasis in mice as well...
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Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice
November 2024
Crocetin displays strong antioxidant, anti-inflammatory and anti-depression activity which is promising to relieve symptoms of fatigue. As a carotenoid, crocetin is difficult to dissolve in water and...
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The meat of the matter: plant-based meat analogue versus traditional meat product nutritional quality
November 2024
Plant-based meat analogues (PBMA) are formulated to mimic the sensory characteristics of traditional meat products (TMP) using vegetarian ingredients and are increasingly popular with the trend towards...
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Association of moderate beer consumption with the gut microbiota
November 2024
Beer is a fermented beverage prepared from water, malted barley, hops, and yeast that has been around for centuries. Alcoholic beverages alter the composition of the gut microbiota, which in turn causes...
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Improved viability of trehalose on Lactobacillus plantarum embedded with whey protein concentrate/pullulan hydrogel in simulated gastrointestinal conditions and its application in juice
November 2024
Trehalose (TRE) was used to improve the gastrointestinal tolerance of Lactobacillus plantarum embedded with whey protein concentrate/pullulan (WPC/PUL) hydrogel and the embedded L. plantarum was applied...
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A novel fluorescence sensor for milk clotting enzyme chymosin using peptide as substrate and covalent organic framework nanosheet as fluorescence quencher
November 2024
Chymosin is one of the critical enzymes in cheese making. Herein, we proposed a novel fluorometric assay for chymosin determination. Firstly, covalent organic frameworks (COF) were synthesized and exfoliated...
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Structural identification and antioxidative activity evaluation of flaxseed lignan macromolecules: structure-activity correlation
November 2024
Flaxseed lignan macromolecules (FLM) are a class of important secondary metabolites in flaxseed, which have been widely concerned due to their biological and pharmacological properties, especially for...
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The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers
November 2024
Ethoxyquin (EQ) is a widely used feed additives for aquaculture, but the potential hazard to fish and consumers are not fully understood. In this work, EQ was applied to tilapia fed with either high-fat...
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Lacticaseibacillus paracasei K56 inhibits lipid accumulation in adipocytes by promoting lipolysis
November 2024
Probiotics crosstalk immunity to improve host glycolipid metabolism, which is a new strategy for obesity. This study aimed to explore the functions of Lacticaseibacillus paracasei K56 (K56), in regulating...
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Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community
November 2024
Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process. Gut mycobiota community dysbiosis has been...
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Oxidative mechanism of chicken wooden breast myofibrillar protein
November 2024
To explore the oxidation mechanism of wooden breast myofibrillar protein (WBMP), oxidative breast MP (OBMP) was obtained from different doses (3, 10, and 20 mmol/L) of H2O2 oxidized normal breast MP...
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Controlled coupling and characterization of oyster (Crassostrea gigas) ferritin with gold nanostars
November 2024
Ferritin has good thermal stability, resistance to certain acids and bases, and targeting, and has broad application prospects in the synthesis of gold nanostars (AuNS). In this study, we screened monodisperse...
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Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers
November 2024
Krill oil (KO) exhibits various biological activities, such as anti-inflammatory and antitumor effects. However, the inhibitory effects of benign prostatic hyperplasia (BPH) in vitro and in vivo have...
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Silver carp muscle hydrolysate ameliorated atherosclerosis and liver injury in apoE-/- mice: the modulator effects on enterohepatic cholesterol metabolism
November 2024
Atherosclerosis (AS) is a major cause of cardiovascular diseases (CVDs) and a strong link with hepatic steatosis. Silver carp muscle hydrolysate (SCH) possess various beneficial activities but its effect...
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Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway
November 2024
Obesity, caused by excessive energy, leads to body weight gain and various diseases, including cognitive impairment. Current studies suggest that diet restriction such as optimal fasting and regular...
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A distinct metabolomic pattern revealed intestinal microenvironment factor-mediated food allergy in a BALB/c mouse model
November 2024
Intestinal immune homeostasis plays a critical role in the pathogenesis of food allergy. However, the association between intestinal microenvironment factors and food allergy severity is not well studied....
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Dendrobium officinale flowers flavonoids enriched extract protects against acute ethanol-induced gastric ulcers via AMPK/PI3K signaling pathways
November 2024
Gastric ulcer is a widespread disease caused by various etiologies. Dendrobium officinale flowers exert several health benefits owing to their rich flavonoid content. In this study, protective effects...
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Virtual screening and directional preparation of xanthine oxidase inhibitory peptides derived from hemp seed protein
November 2024
The traditional nutritional and medical hemp (Cannabis sativa L.) seed protein were explored for the discovery and directional preparation of new xanthine oxidase inhibitory (XOI) peptides by structure-based...
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Evolution of free amino acids, biogenic amines and volatile compounds in fermented sausages inoculated with Lactiplantibacillus plantarum and Staphylococcus simulans
November 2024
Lactic acid bacteria and coagulase-negative staphylococci play an important role in the production of fermented sausages, such as inhibiting the growth of undesirable bacteria and antioxidant. In this...
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The impact of the novel starch-lipid complexes on the glucolipids metabolism, inflammation, and gut dysbiosis of type 2 diabetes mellitus rats
November 2024
It has been widely accepted that resistant starch (RS) provides numerous health benefits for human. In this research, we aimed at evaluating the performance of novel starch-lipid complexes, RS5, in...
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