Hanning FIR window filtering analysis for EEG signals
June 2024
The window function is a mathematical function in signal processing that is multiplied by a signal to lessen or eliminate the impact of undesired characteristics such as spectral leakage and edge effects...
Industry 4.0 and circular economy for bolstering healthcare sector: A comprehensive view on challenges, implementation, and futuristic aspects
June 2024
Industry 4.0 technologies are also strengthening the circular economy and circular healthcare. It is accomplished by implementing methods to reduce waste and undertake advanced sustainability initiatives....
A review of extraction, synthesis, and pharmacological activities of naringenin and its derivatives
September 2025
Naringenin, a polyphenolic flavanone, exhibits diverse pharmacological and biological activities, including anti-inflammatory, antioxidant, anti-obesity, anticancer, antidiabetic, and antimicrobial...
Multi-omics analysis reveals synergistic interplay of metabolic dysregulation, oxidative stress, and inflammation in polycystic ovary syndrome
June 2025
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine and metabolic disorder characterized by hormonal imbalances, metabolic dysfunction, and chronic inflammation. To elucidate the molecular...
3D-Printed microneedle assays for point-of-care applications
June 2025
Microneedle arrays (MNAs) offer a minimally invasive approach for point-of-care (POC) diagnostics, enabling biomarker detection in interstitial fluid (ISF) with reduced discomfort. 3D-printing technology...
The dawn of spatiotemporal transcriptomics
June 2024
Gene expression of cells in the tissues is a heterogeneous and dynamic program across space and time. Spatiotemporal transcriptomics technologies have emerged as transforming tools to dissect the spatiotemporal...
Loofah-Inspired CuS/Fe3O4@BC nanozyme: A multifunctional platform for mercury(II) detection, visual biosensing, and dye degradation
June 2025
The accumulation of toxic heavy metal ions and organic pollutants in biological systems presents critical challenges for clinical diagnostics and therapeutic safety, demanding innovative solutions for...
Molecular docking, molecular dynamics simulation and MM-PB/GBSA analysis for the inhibition of Klebsiella pneumoniae SHV-1 β-lactamase using antimicrobial peptides defensin VvK1 and snakin-1
June 2025
This computational study aims to explore the inhibition property of two plant-derived AMPs (antimicrobial peptides), defensin VvK1 and snakin-1, against SHV-1 β-lactamase from Klebsiella pneumoniae...
A comprehensive study on epigenetic biomarkers in early detection and prognosis of Alzheimer's disease
June 2024
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques and tau tangles, disrupting brain cell communication, causing atrophy, and leading to cognitive decline....
An ensemble machine learning-based approach to predict thyroid disease using hybrid feature selection
September 2024
Thyroid issues are becoming more and more common, and early detection is critical for therapy that reduces mortality and complications. Because of these factors, detecting thyroid problems has become...
Mechanistic insights into the anti-osteoporotic effects of Tripterygium wilfordii via network pharmacology, molecular docking, and experimental validation
September 2025
Tripterygium wilfordii (Lei Gong Teng), a traditional Chinese medicinal herb, has shown potential in promoting bone health, yet its anti-osteoporotic mechanisms remain poorly defined. This study explored...
Unsupervised classification based on m7G-related lncRNAs reveals molecular subtypes of patients with hepatocellular carcinoma
September 2025
The m7G methylation has been demonstrated to play a crucial role in the progression of various tumors. Therefore, we performed molecular subtyping of hepatocellular carcinoma (HCC) patients based on...
One-pot synthesis of magnetic adsorbents with integrated pH regulation for convenient and rapid determination of non-steroidal anti-inflammatory drugs in plasma
September 2025
This work introduces a magnetic nanocomposite created via a one-pot method to produce a magnetic adsorbent with built-in pH regulation capabilities, optimizing the extraction and analysis of non-steroidal...
Optical pickup unit-based fluorescence microscope with autofocus and deep learning capabilities
September 2024
An autofocus, cost-effective fluorescence microscope instrument is made using a commercially available Blu-ray disc optical pickup head (OPU). This ABFM consists of the optical path, system control...
Engineered exosome-based drug delivery system for synergistic cancer therapy via autophagy inhibition and chemotherapy
June 2024
Exosomes (EXOs) are a class of natural nanovesicles secreted endogenously by mammalian cells. Recent decades have witnessed the broad applications of exosomes in cancer diagnosis and treatment. In the...
A comprehensive study on epigenetic signatures to monitor disease progression and the response to therapy in breast cancer
September 2024
Breast cancer is the single most complex cancer type, affecting thousands around the globe annually. With the recent studies highlighting epigenetic signatures in breast cancer detection, this landscape...
Aptamer-carbon quantum dots and silver nanoparticles construct a FRET sensor for sensitive detection of E. coli
June 2024
E. coli is considered to be one of the most dangerous foodborne pathogens and precise detection of E. coli in food is required to ensure the quality and safety of food. In this work, carbon quantum...
Advances in the molecular diagnostic methods for circular RNA
December 2024
Circular RNA (circRNA) is a unique type of non-coding RNA, which is produced by back splicing of mRNA to form the covalent junction without 3′-5′ polarity and poly(A) tail. With the development of detection...
Advances in fluorescence imaging of RNAs in living cells based on functional nucleic acid probes
March 2024
RNA is an essential biomolecule that determines and regulates numerous biological process in cells. The sensitive and specific imaging of the expression level, localization and dynamic change of RNAs...
A label-free fluorescence sensor for bleomycin detection based on a cavity hairpin thioflavin T-light nucleic acid switch
June 2025
Accurate monitoring of bleomycin (BLM) levels in clinical samples is essential for enhancing therapeutic outcomes while minimizing potential toxicity. In this study, we present a label-free fluorescent...
Recent progress in the rational design and applications of nanozymes
March 2025
In order to overcome the limitations of natural enzymes, nanomaterials with enzyme-like activity, commonly named as nanozymes, have been widely studied in the past few decades. Due to their distinctive...
An aptamer-based point-of-care diagnostic test strip for rapid diagnosis of surface spike proteins of SARS-CoV2 virus
September 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has been identified as the causative agent for the COVID-19 pandemic. Herein, we report the development of a point-of-care diagnostic (POC)...
Wearable Janus nanofiber membrane-based colorimetric sensors for directional transfer and analysis of sweat
March 2024
Wearable sweat sensors are promising for real-time personalized health monitoring in a noninvasive manner. However, how to improve the wearing comfort and accuracy affected by sweat accumulation and...
A dual-mode paper-based microfluidic chip for protamine detection
Available online 4 November 2025
Timely and accessible fertility screening remains a challenge for male reproductive health, where privacy and convenience are often critical. Here, we present a dual-mode paper-based microfluidic device...
Chiral nanomaterials for neurodegenerative diseases
June 2024
Chiral nanomaterials with distinctive physical and chemical properties, including circular dichroism, circularly polarized photoluminescence, nonlinear optics, and spintronics, have risen to the forefront...