Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis
July 2026
Osteoarthritis (OA) lacks effective disease-modifying therapies. Nav1.7 has recently been identified as a regulator of both chondrocyte metabolism and pain, establishing it as a dual-acting therapeutic...
Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration
February 2027
The impaired regenerative capacity of osteoporotic individuals poses a significant challenge to the repair of bone defects. In the osteoporotic microenvironment, low pH, excessive reactive oxygen species...
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
October 2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive...
Artificial Intelligence Virtual Organoids (AIVOs)
May 2026
Organoid platforms have reshaped in vitro human biology yet remain constrained by batch variability, sparse longitudinal readouts and barriers to scale. This review introduces Artificial Intelligence...
Bone grafts and biomaterials substitutes for bone defect repair: A review
December 2017
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft...
Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis
January 2027
Osteoarthritis (OA) arises from chondrocyte senescence driven by intertwined oxidative stress and abnormal m6A methylation, with few treatments targeting both pathological pathways. Lycopene, an antioxidant,...
Advances in orthodontic clear aligner materials
April 2023
Rapid technological improvements in biomaterials, computer-aided design (CAD) and manufacturing (CAM) have endorsed clear aligner therapy (CAT) as a mainstay of orthodontic treatment, and the materials...
Ultrasound-activated piezoelectric muscle constructs for tissue-engineered regenerative peripheral nerve interfaces
February 2027
Regenerative peripheral nerve interfaces (RPNIs) are emerging platforms capable to translate neural activity into controllable myoelectric signals. However, current clinical RPNIs rely on muscle autografts,...
In situ bioactive nanocoating enables transocular delivery of permeable drug for dual-location intervention of ocular surface and fundus disorders
March 2027
The concurrency of ocular surface and fundus disorders is prevalent, posing a major threat to vision and quality of life. However, current therapies are difficult to simultaneously manage these coexisting...
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
September 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading...
Bioelectric signals promote diabetic bone regeneration through Piezo1-mediated activation of the efferocytic immune microenvironment
October 2026
Defective macrophage efferocytosis sustains inflammation and compromises bone repair in diabetic defects, yet strategies that restore efferocytic immune homeostasis remain limited. Here, we engineered...
Microalgae extracellular vesicles-loaded dual antioxidative and anti-inflammatory hydrogel system for wound healing and peripheral nerve repair in diabetes
October 2026
Chronic wound healing and peripheral nerve repair in diabetes remain a major clinical challenge due to persistent oxidative stress, inflammation, and impaired tissue regeneration. Here, we developed...
Ion-GPS nanocapsules activate calcium-permeable gates in inflammatory microglia for nerve function recovery
December 2026
Microglia (MG)-mediated immune responses play a pivotal role in the pathophysiological progression and prognosis of spinal cord injury (SCI). However, systematic investigations into the reprogramming...
Rosmarinic acid-cerium nanocatalysts enable oxygenation-enhanced ROS neutralization and PET imaging-guided therapy for acute kidney injury
January 2027
Acute kidney injury (AKI) is driven by a vicious interplay among excessive reactive oxygen species (ROS) accumulation and persistent renal hypoxia, which collectively disrupt redox homeostasis and exacerbate...
Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair
August 2026
The healing of diabetic foot ulcers (DFU) is severely hindered by dysregulated immune microenvironment, recurrent infections, and insufficient angiogenesis. The persistent and resistant nature, coupled...
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming
January 2027
Myocardial infarction (MI) is characterized by severe oxidative stress, excessive inflammation, and profound mitochondrial dysfunction. Although mitochondrial transplantation offers therapeutic promise...
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
December 2023
In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing...
Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing
July 2026
Diabetic wound healing is a complex spatiotemporal process that requires stage-specific interventions to address disrupted neuro-immune interactions and impaired angiogenesis. However, achieving such...
Defining biomaterial-driven design principles for bioabsorbable flow diverters: current state and perspectives
January 2027
Flow diverters (FDs) have revolutionized intracranial aneurysm management, but current permanent metallic devices remain constrained by their bulk and surface properties, which induce chronic inflammation,...
Biodegradable Mg2+-releasing piezoelectric scaffold for segmental bone defect repair
July 2026
Critical-sized bone defects, particularly segmental injuries such as radial defects, remain one of the most formidable challenges in orthopedic regeneration, as spontaneous healing is rarely achieved...
A safe and anti-inflammatory plant-derived nanovesicle platform for targeted delivery in acute lung injury
August 2026
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with extremely high mortality rates, for which effective and safe...
A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds
April 2024
Wound management is an important issue that places enormous pressure on the physical and mental health of patients, especially in cases of infection, where the increased inflammatory response could...
Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis
August 2026
The core pathological process of impaired diabetic wound healing is closely associated with macrophage homeostasis imbalance and defective efferocytosis. To address this clinical challenge, this study...
Gynostemma pentaphyllum-derived extracellular vesicles alleviate skin aging by destabilizing STING
August 2026
Skin aging represents a multifaceted degenerative process that predisposes to dermatological pathologies, including infections, dermatitis, and malignancies, causing great physical and psychological...
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
November 2025
As an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities....
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