Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis
July 2026
Osteoarthritis (OA) lacks effective disease-modifying therapies. Nav1.7 has recently been identified as a regulator of both chondrocyte metabolism and pain, establishing it as a dual-acting therapeutic...
Reprogramming macrophage mechanosensation via TRPV4 modulating mechano-immunotherapy controls fibrotic encapsulation of biomaterial implants
December 2026
Modulating how macrophages sense mechanical cues offers a novel strategy to control fibrosis around implanted biomaterials. We term this approach ‘mechano-immunotherapy’, which involves the desensitization...
Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming
December 2026
Plant-derived nanoparticles (PNPs) have emerged as a promising class of bioactive nanomaterials with intrinsic immunomodulatory properties, offering a sustainable and biocompatible alternative to synthetic...
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
September 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading...
Artificial Intelligence Virtual Organoids (AIVOs)
May 2026
Organoid platforms have reshaped in vitro human biology yet remain constrained by batch variability, sparse longitudinal readouts and barriers to scale. This review introduces Artificial Intelligence...
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
October 2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive...
Accelerated corrosion of 316L stainless steel in a simulated oral environment via extracellular electron transfer and acid metabolites of subgingival microbiota
May 2024
316L stainless steel (SS) is widely applied as microimplant anchorage (MIA) due to its excellent mechanical properties. However, the risk that the oral microorganisms can corrode 316L SS is fully neglected....
A safe and anti-inflammatory plant-derived nanovesicle platform for targeted delivery in acute lung injury
August 2026
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with extremely high mortality rates, for which effective and safe...
Astaxanthin-metformin conjugate nanomicelles-loaded hydrogel reprograms macrophage metabolism via mitochondrion-targeted regulation for diabetic wound healing
October 2026
Diabetic wounds struggle to heal because of ROS-mediated immune dysfunction, in which the mitochondrial metabolic reprogramming of macrophages is critical for inflammation resolution and tissue repair....
Microalgae extracellular vesicles-loaded dual antioxidative and anti-inflammatory hydrogel system for wound healing and peripheral nerve repair in diabetes
October 2026
Chronic wound healing and peripheral nerve repair in diabetes remain a major clinical challenge due to persistent oxidative stress, inflammation, and impaired tissue regeneration. Here, we developed...
Bone grafts and biomaterials substitutes for bone defect repair: A review
December 2017
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft...
Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics
June 2026
The integration of artificial intelligence, protein engineering, and sustainable nanomedicine is driving a paradigm shift in theranostics by enabling highly precise disease diagnosis and targeted therapy....
AI for bioactive materials: From material design to biological applications
October 2026
Bioactive materials are engineered to actively interact with biological systems and induce favorable cellular and tissue responses. The development of bioactive materials is inherently challenging due...
An injectable tough hydrogel sealant enabling rapid hemostasis and promoting oral tissue regeneration
November 2026
Repair of oral soft-tissue injuries remains challenging due to the moist, bacteria-rich, and mechanically active oral environment, as well as the limitations of current sealants in wet adhesion, mechanical...
Nanozyme-crosslinked dual-network hydrogel enables multi-stage modulation of the dysregulated repair cascade for regenerative wound healing
December 2026
Adult mammalian wound healing typically results in fibrosis-associated repair rather than regenerative restoration, a process that can be further exacerbated by persistent inflammation, microbial infection,...
Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis
August 2026
The core pathological process of impaired diabetic wound healing is closely associated with macrophage homeostasis imbalance and defective efferocytosis. To address this clinical challenge, this study...
Biodegradable Mg2+-releasing piezoelectric scaffold for segmental bone defect repair
July 2026
Critical-sized bone defects, particularly segmental injuries such as radial defects, remain one of the most formidable challenges in orthopedic regeneration, as spontaneous healing is rarely achieved...
Bioelectric signals promote diabetic bone regeneration through Piezo1-mediated activation of the efferocytic immune microenvironment
October 2026
Defective macrophage efferocytosis sustains inflammation and compromises bone repair in diabetic defects, yet strategies that restore efferocytic immune homeostasis remain limited. Here, we engineered...
Advances in orthodontic clear aligner materials
April 2023
Rapid technological improvements in biomaterials, computer-aided design (CAD) and manufacturing (CAM) have endorsed clear aligner therapy (CAT) as a mainstay of orthodontic treatment, and the materials...
Design and applications of barrier membranes for guided bone regeneration
October 2026
Despite the placement of millions of dental implants annually, one-quarter to one-half of cases require concurrent guided bone regeneration (GBR), where a recent meta-analysis of 100 studies reported...
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
April 2026
Skin aging is characterized by a progressive decline in regenerative capacity, primarily driven by fibroblast senescence, oxidative stress, chronic inflammation, and the degradation of type I/III collagen,...
Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing
July 2026
Diabetic wound healing is a complex spatiotemporal process that requires stage-specific interventions to address disrupted neuro-immune interactions and impaired angiogenesis. However, achieving such...
A BAI1-PSTB-Hydrogel promotes diabetic wound healing by targeting mtDNA leakage and the cGAS–STING axis to alleviate endothelial senescence
November 2026
Diabetic Wound (DW) is one of the most prevalent complications in diabetes patients, impairing patient wellbeing and quality of life severely. The pathogenesis of DW remains incompletely understood,...
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
December 2023
In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing...
Engineered protein nanoclusters reduce liver fibrosis and hepatocellular carcinoma in mice models
November 2026
Long-term liver injury leads to acute hepatitis and chronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC), which frequently necessitate liver transplantation and are associated...
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