Accelerated corrosion of 316L stainless steel in a simulated oral environment via extracellular electron transfer and acid metabolites of subgingival microbiota
May 2024
316L stainless steel (SS) is widely applied as microimplant anchorage (MIA) due to its excellent mechanical properties. However, the risk that the oral microorganisms can corrode 316L SS is fully neglected....
Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis
July 2026
Osteoarthritis (OA) lacks effective disease-modifying therapies. Nav1.7 has recently been identified as a regulator of both chondrocyte metabolism and pain, establishing it as a dual-acting therapeutic...
Microalgae extracellular vesicles-loaded dual antioxidative and anti-inflammatory hydrogel system for wound healing and peripheral nerve repair in diabetes
October 2026
Chronic wound healing and peripheral nerve repair in diabetes remain a major clinical challenge due to persistent oxidative stress, inflammation, and impaired tissue regeneration. Here, we developed...
Artificial Intelligence Virtual Organoids (AIVOs)
May 2026
Organoid platforms have reshaped in vitro human biology yet remain constrained by batch variability, sparse longitudinal readouts and barriers to scale. This review introduces Artificial Intelligence...
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
September 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading...
A safe and anti-inflammatory plant-derived nanovesicle platform for targeted delivery in acute lung injury
August 2026
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with extremely high mortality rates, for which effective and safe...
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
October 2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive...
Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis
August 2026
The core pathological process of impaired diabetic wound healing is closely associated with macrophage homeostasis imbalance and defective efferocytosis. To address this clinical challenge, this study...
A dual-pronged strategy for bacterial keratitis: ROS-responsive hydrogel eye drops enabling potent deep-tissue antibacterial action and NETs modulation
October 2026
Effective treatment of bacterial keratitis is constrained by poor ocular drug bioavailability and tissue damage caused by bacterial invasion and the subsequent host inflammatory response. Motivated...
Reprogramming macrophage mechanosensation via TRPV4 modulating mechano-immunotherapy controls fibrotic encapsulation of biomaterial implants
December 2026
Modulating how macrophages sense mechanical cues offers a novel strategy to control fibrosis around implanted biomaterials. We term this approach ‘mechano-immunotherapy’, which involves the desensitization...
Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming
December 2026
Plant-derived nanoparticles (PNPs) have emerged as a promising class of bioactive nanomaterials with intrinsic immunomodulatory properties, offering a sustainable and biocompatible alternative to synthetic...
Astaxanthin-metformin conjugate nanomicelles-loaded hydrogel reprograms macrophage metabolism via mitochondrion-targeted regulation for diabetic wound healing
October 2026
Diabetic wounds struggle to heal because of ROS-mediated immune dysfunction, in which the mitochondrial metabolic reprogramming of macrophages is critical for inflammation resolution and tissue repair....
Engineered protein nanoclusters reduce liver fibrosis and hepatocellular carcinoma in mice models
November 2026
Long-term liver injury leads to acute hepatitis and chronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC), which frequently necessitate liver transplantation and are associated...
Bone grafts and biomaterials substitutes for bone defect repair: A review
December 2017
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft...
Sonogenetic flexible nanogels enabling enhanced calcium overload-induced immunogenic cell death for tumor immunotherapy
October 2026
Sonogenetics represents a non-invasive and precise strategy for cancer therapy by coupling ultrasound (US) with genetic engineering. However, achieving efficient deep-tumor delivery and profound immune...
Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics
June 2026
The integration of artificial intelligence, protein engineering, and sustainable nanomedicine is driving a paradigm shift in theranostics by enabling highly precise disease diagnosis and targeted therapy....
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
April 2026
Skin aging is characterized by a progressive decline in regenerative capacity, primarily driven by fibroblast senescence, oxidative stress, chronic inflammation, and the degradation of type I/III collagen,...
AI for bioactive materials: From material design to biological applications
October 2026
Bioactive materials are engineered to actively interact with biological systems and induce favorable cellular and tissue responses. The development of bioactive materials is inherently challenging due...
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
December 2023
In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing...
Mild photothermal-responsive hydrogel with H2Se delivery for anti-infection and microenvironment remodeling to bone regeneration in diabetic osteomyelitis
October 2026
Diabetic osteomyelitis, exacerbated by a hyperglycemic microenvironment, leads to increased bacterial infections and bone tissue destruction, raising the risk of amputation. Current antibiotic therapies...
Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair
August 2026
The healing of diabetic foot ulcers (DFU) is severely hindered by dysregulated immune microenvironment, recurrent infections, and insufficient angiogenesis. The persistent and resistant nature, coupled...
GSH-responsive nanovaccine triggers immunogenic cell death and potent memory T cell immunity for durable, recurrence-free tumor eradication
October 2026
Although nanovaccines hold promise for cancer immunotherapy, the engineering platforms that respond to tumor-specific cues and activate antitumor immunity remains challenging. Herein, a glutathione...
Advances in orthodontic clear aligner materials
April 2023
Rapid technological improvements in biomaterials, computer-aided design (CAD) and manufacturing (CAM) have endorsed clear aligner therapy (CAT) as a mainstay of orthodontic treatment, and the materials...
Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms
January 2026
The extracellular matrix (ECM) serves as a dynamic biomechanical regulator of cellular behavior, yet conventional 3D culture systems, such as Matrigel, lack the spatiotemporal control required to dissect...
An injectable tough hydrogel sealant enabling rapid hemostasis and promoting oral tissue regeneration
November 2026
Repair of oral soft-tissue injuries remains challenging due to the moist, bacteria-rich, and mechanically active oral environment, as well as the limitations of current sealants in wet adhesion, mechanical...
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