Uncovering the profile of ubiquitination motif in catalytic proteins using sequence contextual features
Available online 23 October 2024
Ubiquitin molecules modify their target protein by conjugating the amino group of lysine side chain, thereby regulating the activity and function of most intracellular proteins. However, within multiple...
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Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals
Available online 18 October 2024
The growing incidence of H5Ny virus infection in humans and mammals causes an increasing public health concern. To date, H5Ny virus infection in humans and mammals has been reported in 46 countries...
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Omega-3 polyunsaturated fatty acids, especially DHA and EPA, remold gut microbiota to suppress inflammation in rabbits with atherosclerosis
Available online 19 September 2024
Atherosclerosis (AS) caused by a high-fat diet becomes a critical cause of cardiovascular diseases, which has been regarded as an urgent public health problem. Omega-3 polyunsaturated fatty acids (omega-3...
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Probiotic potential of Bacillus isolated from horses and its therapeutic effect against DSS-induced colitis in mice
Available online 19 September 2024
The superior biological characteristics of probiotics and their therapeutic applicability in the treatment of specific disorders have been proved by accumulating evidence. Although horses are susceptible...
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Oral administration of antimicrobial peptide MPX ameliorates orchitis and inflammatory damage in other organs
Available online 2 July 2024
Bacterial orchitis has a very high percentage of reproductive diseases in males. Therefore, specific medicines are urgently needed to prevent and treat orchitis. Antimicrobial peptides (AMPs) are widely...
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Emerging role of ruminal microbiota in the development of perinatal bovine diseases
Available online 2 July 2024
As the largest and most important digestive organ of ruminant, rumen was a natural fermentation tank of dairy cows, in which there were many kinds of microorganisms. These microorganisms constituted...
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Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2
Available online 1 July 2024
The pandemic of coronavirus disease 2019 (COVID-19) is no longer a global health emergency, but variants of the causative agent (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) are still...
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The NF-κB pathway negatively regulates the replication of rabies virus by triggering inflammatory responses
Available online 29 June 2024
Rabies, which is caused by the rabies virus (RABV), is a neurological disease of mammals, including humans. The disease is untreatable, as drugs and antibodies are prevented from entering brain tissue...
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Rheumatoid arthritis animal model in mice
Available online 25 June 2024
Rheumatoid arthritis (RA) is an autoimmune disease that causes significant disability and has a high recurrence rate. Currently, there is no cure for this disease. Identifying the cause of RA and developing...
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Focusing on animals and zoonotic diseases, serving humanity's great health
Available online 21 May 2024
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