Virulence factors in biofilm formation and therapeutic strategies for Staphylococcus aureus: A review
June 2025
Staphylococcus aureus (S. aureus) is a significant human pathogen known for its ability to form biofilms, which increase its resistance to antibiotics and immune defenses. This review delves into the...
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Rheumatoid arthritis animal model in mice
March 2025
Rheumatoid arthritis (RA) is an autoimmune disease that causes significant disability and has a high recurrence rate. Currently, there is no cure for this disease. Identifying the cause of RA and developing...
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Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2
March 2025
The pandemic of coronavirus disease 2019 (COVID-19) is no longer a global health emergency, but variants of the causative agent (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) are still...
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Experimental animal models for urolithiasis (kidney stone): A comprehensive review
Available online 7 March 2025
Experimental animal models play a crucial role in scientific research in different fields such as medicine, biology and pharmacology. Animal models help to understanding human physiology and pathology...
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Monkeypox immunity: A landscape of host-virus interactions, vaccination strategies, and future research horizons
March 2025
Monkeypox virus (MPXV) is the cause of monkeypox (mpox), which is a viral zoonotic disease similar to smallpox. It is currently a re-emerging and a cause of global concern for human health. The emergence...
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Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals
March 2025
The growing incidence of H5Ny virus infection in humans and mammals causes an increasing public health concern. To date, H5Ny virus infection in humans and mammals has been reported in 46 countries...
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Emerging role of ruminal microbiota in the development of perinatal bovine diseases
March 2025
As the largest and most important digestive organ of ruminant, rumen was a natural fermentation tank of dairy cows, in which there were many kinds of microorganisms. These microorganisms constituted...
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A dual-purpose monoclonal antibody for in vitro neutralization and diagnostic detection of the lumpy skin disease virus
March 2025
The global cattle industry faces a persistent threat from lumpy skin disease virus (LSDV), resulting in significant economic losses and creating an urgent need for effective therapeutic and preventive...
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Probiotic potential of Bacillus isolated from horses and its therapeutic effect against DSS-induced colitis in mice
March 2025
The superior biological characteristics of probiotics and their therapeutic applicability in the treatment of specific disorders have been proved by accumulating evidence. Although horses are susceptible...
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Construction and immunogenicity of recombinant Lactiplantibacillus plantarum vaccine candidate expressing SARS-CoV-2 Omicron S1 protein
March 2025
The current intramuscular SARS-CoV-2 vaccine failed to prevent variant strain outbreaks due to its inadequate stimulation of mucosal immunity. Therefore, nasal immunization is emerging as a promising...
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Oral administration of antimicrobial peptide MPX ameliorates orchitis and inflammatory damage in other organs
March 2025
Bacterial orchitis has a very high percentage of reproductive diseases in males. Therefore, specific medicines are urgently needed to prevent and treat orchitis. Antimicrobial peptides (AMPs) are widely...
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Prevalence of zoonotic diseases in the Northeastern region, one health perspective
June 2025
Zoonotic diseases are long known for their disease transmission from animals to human beings or from human beings to animals. These illnesses are primarily spread by the ingestion of contaminated food...
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The NF-κB pathway negatively regulates the replication of rabies virus by triggering inflammatory responses
March 2025
Rabies, which is caused by the rabies virus (RABV), is a neurological disease of mammals, including humans. The disease is untreatable, as drugs and antibodies are prevented from entering brain tissue...
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Host immune response to Cryptosporidium spp.: Insights and perspectives for vaccine development
June 2025
Cryptosporidium, a zoonotic protozoan parasite, poses a significant threat to both public health and the livestock sectors globally, leading to lethal diarrheal disease and associated economic losses....
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Pathogens infected or carried by exotic pets pose emerging threat to human health
June 2025
Exotic pets refer to a variety of uncommon pets that are different from traditional pets such as cats, dogs, birds and fish. Due to the convenience of international travel, the diversity and globalization...
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Advances in mammalian ovarian tissue cryopreservation
Available online 20 February 2025
In mammals, the ovum is one of the largest cells with a relatively small ratio of surface area to cytoplasm and unique biological characteristics. The quantity of ova in the ovary is very limited and...
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A comprehensive review of tick-borne disease epidemiology, clinical manifestations, pathogenesis, and prevention
Available online 21 May 2025
Ticks are arthropod vectors that transmit pathogens by biting and bloodsucking, and they have been found to carry or transmit over one hundred types of pathogens. The majority of these pathogens are...
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Prevention of Clostridium perfringens induced chicken necrotic enteritis by probiotics: A review
Available online 21 February 2025
Necrotic enteritis (NE), predominantly affecting poultry with significant disorder, is mainly caused by bacterial pathogen Clostridium perfringens. The restriction of growth enhancers based on animal...
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Progress in the molecular epidemiology of chikungunya virus
June 2025
In recent years, with the global climate warming up, Aedes albopictus and Aedes aegypti have gradually expanded their range of activities from the tropics to subtropical and temperate regions, which...
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Regulation of immune metabolism in Th17 and Treg cells
Available online 28 February 2025
Immunometabolism is the intersection between immunity and metabolism, and the effects of some important metabolic pathways on the development, differentiation, activation and function of immune cells...
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The cellular host factors for severe fever with thrombocytopenia syndrome virus infection
June 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered life-threatening disease caused by SFTS virus (SFTSV), an emerging tick-borne bunyavirus. The severity of SFTSV infection can...
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Advances in endometrial receptivity and embryo implantation by multi-omics techniques
Available online 19 May 2025
Endometrial receptivity is a critical determinant of successful embryo implantation, yet current clinical assessments (e.g., ultrasound, hysteroscopy) primarily focus on morphological evaluation and...
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Critical role of cellular microRNAs in virus infection: Decades of progress
Available online 13 January 2025
MicroRNAs, or miRNAs, play a critical role in the complex interplay between viruses and their host organisms during viral infections. Over the past several decades, investigations into the functions...
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Epidemiological survey of cat infectious diseases in China from 2022 to 2023
Available online 10 April 2025
The study investigates and analyzes the positive rates of 11 cat pathogens in 14 provinces across China from 2022 to 2023. The aim is to enhance understanding of the epidemiological characteristics...
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