A comprehensive review of tick-borne disease epidemiology, clinical manifestations, pathogenesis, and prevention
September 2025
Ticks are arthropod vectors that transmit pathogens by biting and bloodsucking, and they have been found to carry or transmit over one hundred types of pathogens. The majority of these pathogens are...
Virulence factors in biofilm formation and therapeutic strategies for Staphylococcus aureus: A review
June 2025
Staphylococcus aureus (S. aureus) is a significant human pathogen known for its ability to form biofilms, which increase its resistance to antibiotics and immune defenses. This review delves into the...
Experimental animal models for urolithiasis (kidney stone): A comprehensive review
September 2025
Experimental animal models play a crucial role in scientific research in different fields such as medicine, biology and pharmacology. Animal models help to understanding human physiology and pathology...
Advances in endometrial receptivity and embryo implantation by multi-omics techniques
September 2025
Endometrial receptivity is a critical determinant of successful embryo implantation, yet current clinical assessments (e.g., ultrasound, hysteroscopy) primarily focus on morphological evaluation and...
Pathogens infected or carried by exotic pets pose emerging threat to human health
June 2025
Exotic pets refer to a variety of uncommon pets that are different from traditional pets such as cats, dogs, birds and fish. Due to the convenience of international travel, the diversity and globalization...
Rheumatoid arthritis animal model in mice
March 2025
Rheumatoid arthritis (RA) is an autoimmune disease that causes significant disability and has a high recurrence rate. Currently, there is no cure for this disease. Identifying the cause of RA and developing...
The cellular host factors for severe fever with thrombocytopenia syndrome virus infection
June 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered life-threatening disease caused by SFTS virus (SFTSV), an emerging tick-borne bunyavirus. The severity of SFTSV infection can...
Prevalence of zoonotic diseases in the Northeastern region, one health perspective
June 2025
Zoonotic diseases are long known for their disease transmission from animals to human beings or from human beings to animals. These illnesses are primarily spread by the ingestion of contaminated food...
Zoonotic diseases in low and middle-income countries (LMICs): Economic burden, challenges, strategies, and future directions
Available online 5 November 2025
More than 200 zoonotic diseases are known to affect humans, representing a significant share of both emerging and existing infectious diseases worldwide. These diseases pose a major global public health...
Combining herbal fermentation with Lactobacillus expressing recombinant PEDV-S1 protein offers protection against PEDV infection
September 2025
The porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea, an acute, highly contagious infectious disease that has caused significant economic losses in the global pig industry. Due...
Advances in mammalian ovarian tissue cryopreservation
September 2025
In mammals, the ovum is one of the largest cells with a relatively small ratio of surface area to cytoplasm and unique biological characteristics. The quantity of ova in the ovary is very limited and...
Flagellin: A crucial virulence factor coordinating bacterial pathogenesis and host immune responses
Available online 18 September 2025
Flagella serve as the motility organs of bacteria, possessing not only the capability to facilitate movement through mechanisms such as rotation and swinging but also playing a crucial role in the establishment...
Host immune response to Cryptosporidium spp.: Insights and perspectives for vaccine development
June 2025
Cryptosporidium, a zoonotic protozoan parasite, poses a significant threat to both public health and the livestock sectors globally, leading to lethal diarrheal disease and associated economic losses....
Recent progress on rapid diagnostic methods for viral diseases
Available online 30 October 2025
Viral diseases pose a persistent and evolving threat to global public health, with far-reaching impacts on clinical practice, epidemiology, and socioeconomic stability. Over the past decade, frequent...
Prevention of Clostridium perfringens induced chicken necrotic enteritis by probiotics: A review
Available online 21 February 2025
Necrotic enteritis (NE), predominantly affecting poultry with significant disorder, is mainly caused by bacterial pathogen Clostridium perfringens. The restriction of growth enhancers based on animal...
Progress in the molecular epidemiology of chikungunya virus
June 2025
In recent years, with the global climate warming up, Aedes albopictus and Aedes aegypti have gradually expanded their range of activities from the tropics to subtropical and temperate regions, which...
Critical role of cellular microRNAs in virus infection: Decades of progress
Available online 13 January 2025
MicroRNAs, or miRNAs, play a critical role in the complex interplay between viruses and their host organisms during viral infections. Over the past several decades, investigations into the functions...
Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals
March 2025
The growing incidence of H5Ny virus infection in humans and mammals causes an increasing public health concern. To date, H5Ny virus infection in humans and mammals has been reported in 46 countries...
Epidemiological survey of cat infectious diseases in China from 2022 to 2023
September 2025
The study investigates and analyzes the positive rates of 11 cat pathogens in 14 provinces across China from 2022 to 2023. The aim is to enhance understanding of the epidemiological characteristics...
Regulation of immune metabolism in Th17 and Treg cells
September 2025
Immunometabolism is the intersection between immunity and metabolism, and the effects of some important metabolic pathways on the development, differentiation, activation and function of immune cells...
Construction and immunogenicity of recombinant Lactiplantibacillus plantarum vaccine candidate expressing SARS-CoV-2 Omicron S1 protein
March 2025
The current intramuscular SARS-CoV-2 vaccine failed to prevent variant strain outbreaks due to its inadequate stimulation of mucosal immunity. Therefore, nasal immunization is emerging as a promising...
Emerging challenges and advances in porcine viral pathogenesis: A decade in review
Available online 4 July 2025
The past decade has witnessed unprecedented challenges posed by porcine viruses, driven by globalization and intensive livestock practices. This review consolidates critical findings from recent literature,...
Emerging role of ruminal microbiota in the development of perinatal bovine diseases
March 2025
As the largest and most important digestive organ of ruminant, rumen was a natural fermentation tank of dairy cows, in which there were many kinds of microorganisms. These microorganisms constituted...
Uncovering the profile of ubiquitination motif in catalytic proteins using sequence contextual features
June 2025
Ubiquitin molecules modify their target protein by conjugating the amino group of lysine side chain, thereby regulating the activity and function of most intracellular proteins. However, within multiple...
Berberine hydrochloride attenuates avian pathogenic Escherichia coli-induced macrophage inflammation via NAD⁺/NADH-SIRT1-NF-κB regulatory axis
September 2025
Avian pathogenic Escherichia coli (APEC) poses a significant threat to the poultry industry, primarily causing multisystemic infections through respiratory tract invasion, which can lead to acute mortality....