Gianni Parise
Deputy Editors-in-Chief, Advanced Exercise and Health Science
Department of Kinesiology, McMaster University, Canada
Department of Kinesiology, McMaster University, Canada
Website: https://kinesiology.mcmaster.ca/emrg/labs/molecular-exercise-physiology-muscle-aging-lab/
Email: pariseg@mcmaster.ca
Introduction: My research interests revolve around understanding the mechanisms of skeletal muscle repair and adaptation to damage and exercise in humans. Our primary focus is on muscle stem cells and how they are regulated in response to acute, damaging exercise as well as exercise training. Specifically, we explore the relationships between muscle stem cells and adjacent anatomical structures, such as other cell types including inflammatory cells, fibroblasts and endothelial cells. We also investigate the specific cytokines and growth factors that influence muscle stem cell activation, proliferation and differentiation. We investigate many of these same issues in the context of aging skeletal muscle to understand why muscle stem cells fail in aging. Perhaps more importantly, we investigate how muscle stem cell function can be rescued through nutrition and exercise.